Immunorestorative effects of reimplanted splenic tissue and splenosis

Lüdtke, F. E.; Schuff‐Werner, P.; Lion, K.A.; Speer, C P

doi:10.1016/0022-4804(90)90189-9

Cited by 12 publications

(13 citation statements)

References 21 publications

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“…Two studies used the same patient cohort, and the earlier study with fewer data points was excluded [23] . This left a total of 18 primary studies [24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41] . Reviewing reference lists from these studies identified no other eligible articles.…”

Section: Search Strategy and Selectionmentioning

confidence: 99%

Splenic autotransplantation: a systematic review

Surendran

Smith

Houli

et al. 2019

ANZ Journal of Surgery

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Background: Splenectomy is a surgical procedure indicated in a variety of medical conditions including trauma. Postoperatively, there is a lifelong risk of developing overwhelming sepsis from encapsulated bacteria, most commonly due to Streptococcus pneumoniae. Splenic autotransplantation has been proposed as a method to recover splenic function in patients requiring splenectomy with otherwise normal spleens. This paper aims to systematically review the literature to determine the efficacy of spleen autotransplantation.Methods: MEDLINE, PubMed and the Cochrane Library were searched for all studies assessing splenic autotransplantation (January 1947 to July 2018). Data was extracted on study characteristics, outcomes assessed, including spleen scintigraphy results, blood film counts and serum immunoglobulin levels.Results: Data was obtained from 18 primary studies. All papers demonstrated return of regenerated spleen tissue in the majority of their patients (95.3%) on spleen scintigraphy. 90.2% of patients in 12 studies had blood films return to normal following transplantation. Immunoglobulin levels were shown to return to normal in all 12 studies where it was assessed. 3.7% of patients in 11 studies had postoperative complications.1.3% of patients in five studies had postoperative infections in the follow-up period.

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Section: Search Strategy and Selectionmentioning

confidence: 99%

Splenic autotransplantation: a systematic review

Surendran

Smith

Houli

et al. 2019

ANZ Journal of Surgery

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“…Another possible limitation of the laparoscopic approach is splenosis due to inadvertent capsular breaching or spillage during extraction 22 . Although the incidence of splenosis following elective open splenectomy is rare, 22,23 and the immunorestorative effects of reimplanted splenic tissue is minimal, 15,24 the theoretical concern regarding the risk of splenic tissue spillage has contributed to some surgeons being reluctant to utilize the laparoscopic approach. We stress the importance of minimal direct handling of the spleen to avoid capsular breaches, together with the routine use of a tissue extraction device such as a purpose‐built specimen bag to minimize splenosis.…”

Section: Discussionmentioning

confidence: 99%

Technical developments and a team approach leads to an improved outcome: Lessons learnt implementing laparoscopic splenectomy

Chan

Hensman

Waxman

et al. 2002

ANZ Journal of Surgery

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A reduction in conversion rates, operating time, morbidity and length of stay was realized during the learning curve of implementing laparoscopic splenectomy by adopting a standardized technique. This technique involved hilar dissection using the ultrasonic shears, two experienced laparoscopic surgeons performing the surgery, dedicated equipment and trained staff using the checklist approach. We recommend such a standardized technique in performing laparoscopic splenectomy.

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“…15 Another possible limitation of the laparoscopic approach is splenosis due to inadvertent capsular breaching or spillage during extraction. 22 Although the incidence of splenosis following elective open splenectomy is rare, 22,23 and the immunorestorative effects of reimplanted splenic tissue is minimal, 15,24 the theoretical concern regarding the risk of splenic tissue spillage has contributed to some surgeons being reluctant to utilize the laparoscopic approach. We stress the importance of minimal direct handling of the spleen to avoid capsular breaches, together with the routine use of a tissue extraction device such as a purpose-built specimen bag to minimize splenosis.…”

Section: Discussionmentioning

confidence: 99%

Statistical Methods in Medical Research, 4th edition. By P. Armitage, G. Berry and J. N. S. Matthews.

Dent¹

2002

ANZ Journal of Surgery

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Immunorestorative effects of reimplanted splenic tissue and splenosis

Cited by 12 publications

References 21 publications

Splenic autotransplantation: a systematic review

Splenic autotransplantation: a systematic review

Technical developments and a team approach leads to an improved outcome: Lessons learnt implementing laparoscopic splenectomy

Statistical Methods in Medical Research, 4th edition. By P. Armitage, G. Berry and J. N. S. Matthews.

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