Immunoregulatory properties of hexapeptide isolated from porcine bone marrow cell culture

Mikhailova, A. V.; Fonina, L. A.; Kirilina, E. A.; Shanurin, S.Y.; Gur'yanov, S. A.; Malakhov, A. A.; Nesmeyanov, V. A.; Петров, Р. В.

doi:10.1016/0167-0115(94)90169-4

Cited by 22 publications

(10 citation statements)

References 12 publications

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“…Our previous studies showed that MP-1 in a concentration of 10 -8 g/ml in vitro decreases phagocytic activity of neutrophils [2]. It should be emphasized that the key immunoregulatory effect of this peptide are recovery of antibody production after exposure to inhibitory factors due to specific low-affinity binding to the surface of CD4 + lymphocytes [3,7] and liquidation of CD4 + / CD8 + imbalance caused by concanavalin A. The abi- lity of MP-1 to normalize immune parameters contributes to its inhibitory effect on proliferation in the presence of high concentration of the mitogen.…”

Section: Resultsmentioning

confidence: 99%

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Mechanism Underlying the Effect of Myelopeptides on Lymphocyte Proliferation in Vitro

et al. 2005

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Section: Resultsmentioning

confidence: 99%

“…This effect is mediated by the interaction of MP with specific cell populations. MP-1 has specific binding sites on T lymphocytes [3,7]. MP-3 activates monocytes and macrophages [1].…”

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confidence: 99%

Mechanism Underlying the Effect of Myelopeptides on Lymphocyte Proliferation in Vitro

et al. 2005

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“…Incubation with mAB was carried out for 40 min on ice. Cell suspensions were then washed twice in a buffer and fluorescence of stained cells was measured on a EPICS ELITE laser flow cytofluorometer/sorter (Coulter Electronics Inc.) [1,6].…”

Section: Methodsmentioning

confidence: 99%

Induction of Differentiation in Leukemic Cell Strains with Myelopeptide-4

et al. 2005

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We studied the capacity of myelopeptide-4 (regulatory peptide of the bone marrow origin) to induce terminal differentiation of HL-60 and K-562 leukemic cells. Myelopeptide-4 increased the expression of CD14 and CD38 differentiation antigens on the surface of HL-60 cells and of CD44 antigen on K-562 cells, induced the appearance of mature monocyte/macrophages in HL-60 culture and hemoglobin-producing cells in K-562 cell culture, and stimulated phagocytic activity of THP-1 leukemic cells. Myelopeptide-4 is an endogenous factor of cell differentiation, a prospective agent for antileukemic therapy.

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“…Finally, haemoglobin fragments similar or very close to those represented in Table 2 were isolated earlier from human pituitary gland material [20], cerebellum [21], liquor [22] and gingival crevicular fluid [23]; pig hypothalmus [24] and bone marrow [25]; bovine brain [26±28] and bone marrow [29].…”

Section: Isolation and Identification Of Peptide Components From Bovimentioning

confidence: 99%

Peptides from bovine brain: structure and biological role

et al. 1998

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Fractionation of bovine brain extracts followed by automatic Edman sequencing of individual components resulted in identification of 107 endogenous peptides formed from functional proteins (haemoglobin, myelin basic protein, cytochrome c oxidase, etc) or unknown precursors. Several of the newly identified brain peptides demonstrate different types of biological activity; some of the substances show considerable overlap with the known biologically active peptides. It is suggested that these peptides should participate in regulation of extracellular and intracellular biochemical processes. A concept of 'tissue-specific peptide pool' is formulated describing a novel system of peptidergic regulation, complementary to the conventional hormonal and neuromodulatory systems. According to that description functional proteins provide their proteolytically derived fragments for maintaining the tissue homeostasis by modulating the availability of peptide receptors to respective 'true' ligands.

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Immunoregulatory properties of hexapeptide isolated from porcine bone marrow cell culture

Cited by 22 publications

References 12 publications

Mechanism Underlying the Effect of Myelopeptides on Lymphocyte Proliferation in Vitro

Mechanism Underlying the Effect of Myelopeptides on Lymphocyte Proliferation in Vitro

Induction of Differentiation in Leukemic Cell Strains with Myelopeptide-4

Peptides from bovine brain: structure and biological role

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