Immunoregulatory Mechanisms Underlying Prevention of Colitis-Associated Colorectal Cancer by Probiotic Bacteria

Bassaganya‐Riera, Josep; Viladomiu, Monica; Pedragosa, Mireia; Simone, Claudio De; Hontecillas, Raquel

doi:10.1371/journal.pone.0034676

Cited by 104 publications

(59 citation statements)

References 45 publications

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“…Bassaganya-Riera et al [75] (2012) studied the cellular and molecular mechanisms underlying the efficacy of probiotic bacteria in mouse models of inflammation-driven colorectal cancer. Immune cell subsets in the MLN, spleen and colonic lamina propria lymphocytes (LPL) were phenotypically and functionally characterized.…”

Section: Probiotic Strain Genes Involvedmentioning

confidence: 99%

“…Inflammatory bowel disease Disfrutti et al [71] VSL#3 IL-10, TNFRSF1B Ghadimi et al [72] B. breve (DSMZ 20213) and L. rhamnosus GG IL-17 and IL-23 Grimoud et al [73] B. breve and L. lactis TLR-4 Chen et al [74] Saccharomyces boulardii VEGF Bassaganya-Riera et al [75] VSL#3 TNF-α, COX-2, and PPAR-γ Ulcerative colitis…”

Section: Table 2 Regulation Of Gene Expression By Probiotics In Inflamentioning

confidence: 99%

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Modulation of immunity and inflammatory gene expression in the gut, in inflammatory diseases of the gut and in the liver by probiotics

Plaza‐Díaz¹

2014

WJG

178

120

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The potential for the positive manipulation of the gut microbiome through the introduction of beneficial microbes, as also known as probiotics, is currently an active area of investigation. The FAO/WHO define probiotics as live microorganisms that confer a health benefit to the host when administered in adequate amounts. However, dead bacteria and bacterial molecular components may also exhibit probiotic properties. The results of clinical studies have demonstrated the clinical potential of probiotics in many pathologies, such as allergic diseases, diarrhea, inflammatory bowel disease and viral infection. Several mechanisms have been proposed to explain the beneficial effects of probiotics, most of which involve gene expression regulation in specific tissues, particularly the intestine and liver. Therefore, the modulation of gene expression mediated by probiotics is an important issue that warrants further investigation. In the present paper, we performed a systematic review of the probiotic-mediated modulation of gene expression that is associated with the immune system and inflammation. Between January 1990 to February 2014, PubMed was searched for articles that were published in English using the MeSH terms "probiotics" and "gene expression" combined with "intestines", "liver", "enterocytes", "antigen-presenting cells", "dendritic cells", "immune system", and "inflammation". Two hundred and five original articles matching these criteria were initially selected, although only those articles that included specific gene expression results (77) were later considered for this review and separated into three major topics: the regulation of immunity and inflammatory gene expression in the gut, in inflammatory diseases of the gut and in the liver. Particular strains of Bifidobacteria, Lactobacilli, Escherichia coli, Propionibacterium, Bacillus and Saccharomyces influence the gene expression of mucins, Toll-like receptors, caspases, nuclear factor-κB, and interleukins and lead mainly to an anti-inflammatory response in cultured enterocytes. In addition, the interaction of commensal bacteria and probiotics with the surface of antigen-presenting cells in vitro results in the downregulation of pro-inflammatory genes that are linked to inflammatory signaling pathways, whereas other anti-inflammatory genes are upregulated. The effects of probiotics have been extensively investigated in animal models ranging from fish to mice, rats and piglets. These bacteria induce a tolerogenic and hyporesponsive immune response in which many genes that are related to the immune system, in particular those genes expressing anti-inflammatory cytokines, are upregulated. By contrast, information related to gene expression in human intestinal cells mediated by the action of probiotics is scarce. There is a need for further clinical studies that evaluate the mechanism of action of probiotics both in healthy humans and in patients with chronic diseases. These types of clinical studies are necessary for addressing the influence of these microorga...

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Section: Probiotic Strain Genes Involvedmentioning

confidence: 99%

Section: Table 2 Regulation Of Gene Expression By Probiotics In Inflamentioning

confidence: 99%

Modulation of immunity and inflammatory gene expression in the gut, in inflammatory diseases of the gut and in the liver by probiotics

Plaza‐Díaz¹

2014

WJG

178

120

View full text Add to dashboard Cite

show abstract

“…This suggests that sericin might have an effect on the function of cytotoxic T cells but it may not affect helper T cells. Despite the essential role of CD8 cell in anti-viral immunity, CD4 T cells can also play important roles for control of viral infection as well as cancer 26,27 . There was a reduction of CD80 positive cells without changes in CD86 positive cells.…”

Section: Discussionmentioning

confidence: 99%

The effect of dietary sericin on rats

Keawkorn¹,

Limpeanchob²,

Tiyaboonchai³

et al. 2013

ScienceAsia

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Dietary proteins have been reported to be beneficial for lipid metabolism, tissue growth, development, and repair, as well as immune response. The interactions of dietary proteins and their digested products may regulate the physiology and metabolism of the gastrointestinal tract. However, proteins are largely digested before reaching the large intestine. The present study investigated the use of the non-dietary protein, silk sericin, in rats. Rats were fed either with casein or sericin proteins. Their body weight, food consumption, and complete blood count were measured. The results showed that during the experimental periods, rats fed with casein and sericin diets had no significant changes on body weight, food consumption, or complete blood count. Sericin-fed rats had a significantly decreased CD8a and CD80 positive cells when compared with standard casein protein.In conclusion, dietary proteins may have a differential impact on the leukocyte profile. The mechanisms underlying these changes are not clear but they might be due to the different amino acid compositions of the proteins studied.

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“…bulgaricus, which could inhibit colonocytes proliferation by inducing proapoptotic pathway by regulation of the concentration of COX-2 in colon. [137] Putaala et al demonstrated that the probiotics are involved in the inhibition of colon carcinogenesis by the downregulation of COX-2. [138] In another study, Otte et al showed that probiotics were able to regulate COX-2 gene expression significantly in comparison to heat inactivated probiotics.…”

Section: Irritable Bowel Syndromementioning

confidence: 99%

Clinical significance of probiotics in human

Jain

Chaudhary

2014

Int J Nutr Pharmacol Neurol Dis

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This review gives a glimpse of probiotic role in human life and how it affects the individual. Probiotics have been studied as an alternative to antibiotic therapy. The term "probiotics" comes from the Greek word "pro bios" meaning "for life" opposed to "antibiotics," which means "against life." As the research is progressing, new approaches to treat diseases are being developed such as prebiotics and synbiotics. Probiotics work in our body through various modes of action, namely, production of inhibitory substances, stimulation of immunity, affecting host gene expression, blocking of adhesion sites, competition for nutrients, and degradation of toxin receptors. The various criteria employed to select strains for probiotics are acid-bile stability, adhesion stability, antimicrobial activity, viability and stability during processing and storage. Research has proved the therapeutic effects of probiotics in diseases such as diarrhea, rotavirus diarrhea, irritable bowel syndrome, Helicobacter pylori infection, hepatic encephalopathy, celiac disease, and hyperoxaluria. Probiotics have prophylactic effects in diseases such as pouchitis and ulcerative colitis that come under inflammatory bowel disease, antibiotic-induced diarrhea, necrotizing enterocolitis, ventilator-associated pneumonia, dental decay, periodontal infection, halitosis, constipation, gastrointestinal infections, and colon cancer. Probiotics also help in xenobiotic metabolism, lactose intolerance, cholesterol reduction, sucrase-isomaltase deficiency, stress, and hypertension. Further research is needed to prove the efficacy of probiotics in case of radiation-induced diarrhea, HIV/AIDS diarrhea, Crohn's disease, nonalcoholic fatty liver disease, and allergy.

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Immunoregulatory Mechanisms Underlying Prevention of Colitis-Associated Colorectal Cancer by Probiotic Bacteria

Cited by 104 publications

References 45 publications

Modulation of immunity and inflammatory gene expression in the gut, in inflammatory diseases of the gut and in the liver by probiotics

Modulation of immunity and inflammatory gene expression in the gut, in inflammatory diseases of the gut and in the liver by probiotics

The effect of dietary sericin on rats

Clinical significance of probiotics in human

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