Immunoregulatory Effects of Tolerogenic Probiotics in Multiple Sclerosis

Atabati, Hadi; Yazdanpanah, Esmaeil; Mortazavi, Hamed; Bajestani, Saeed Gharibian; Raoofi, Amir; Esmaeili, Seyed‐Alireza; Khaledi, Azad; Saburi, Ehsan; Afshari, Jalil Tavakol; Sathyapalan, Thozhukat; Moghaddam, Abbas Shapouri; Sahebkar, Amirhossein

doi:10.1007/978-3-030-55035-6_6

Cited by 18 publications

(11 citation statements)

References 125 publications

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“…It is also recommended to do a before-and-after analysis of the gut microbiota with regards to the highly individually specific and in some regards resistant gut microbiota ( 232 ). In other neuroimmunological diseases, such as MS, a recent review concluded that probiotics modulate the immune system, respectively upregulating Treg cells, anti-inflammatory cytokines and decreasing inflammatory monocytes ( 233 ). One of the studies reviewed showed probiotic supplementation decreased dysbiosis associated taxa and to increase the abundance of Lactobacillus and Bifidobacterium ( 234 ).…”

Section: The Role Of the Gut Microbiome In Me/cfsmentioning

confidence: 99%

The Gut Microbiome in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS)

et al. 2022

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Myalgic encephalomyelitis (ME) or Chronic Fatigue Syndrome (CFS) is a neglected, debilitating multi-systemic disease without diagnostic marker or therapy. Despite evidence for neurological, immunological, infectious, muscular and endocrine pathophysiological abnormalities, the etiology and a clear pathophysiology remains unclear. The gut microbiome gained much attention in the last decade with manifold implications in health and disease. Here we review the current state of knowledge on the interplay between ME/CFS and the microbiome, to identify potential diagnostic or interventional approaches, and propose areas where further research is needed. We iteratively selected and elaborated on key theories about a correlation between microbiome state and ME/CFS pathology, developing further hypotheses. Based on the literature we hypothesize that antibiotic use throughout life favours an intestinal microbiota composition which might be a risk factor for ME/CFS. Main proposed pathomechanisms include gut dysbiosis, altered gut-brain axis activity, increased gut permeability with concomitant bacterial translocation and reduced levels of short-chain-fatty acids, D-lactic acidosis, an abnormal tryptophan metabolism and low activity of the kynurenine pathway. We review options for microbiome manipulation in ME/CFS patients including probiotic and dietary interventions as well as fecal microbiota transplantations. Beyond increasing gut permeability and bacterial translocation, specific dysbiosis may modify fermentation products, affecting peripheral mitochondria. Considering the gut-brain axis we strongly suspect that the microbiome may contribute to neurocognitive impairments of ME/CFS patients. Further larger studies are needed, above all to clarify whether D-lactic acidosis and early-life antibiotic use may be part of ME/CFS etiology and what role changes in the tryptophan metabolism might play. An association between the gut microbiome and the disease ME/CFS is plausible. As causality remains unclear, we recommend longitudinal studies. Activity levels, bedridden hours and disease progression should be compared to antibiotic exposure, drug intakes and alterations in the composition of the microbiota. The therapeutic potential of fecal microbiota transfer and of targeted dietary interventions should be systematically evaluated.

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Section: The Role Of the Gut Microbiome In Me/cfsmentioning

confidence: 99%

The Gut Microbiome in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS)

et al. 2022

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“…In the literature archive, the therapeutic potential of these microbiota has been linked to the diagnosis, management, and treatment of various disorders [ 5 ]. They have been associated with the prevention and progression of various central nervous system disorders like multiple sclerosis [ 6 , 7 ]. They have also been linked to the prevention and treatment of cardiovascular diseases like hypertension [ 8 , 9 ], along with enhanced predisposition towards various viral and bacterial infections.…”

Section: Introductionmentioning

confidence: 99%

Biodiversity of Gut Microbiota: Impact of Various Host and Environmental Factors

Anwar

Iftikhar

Muzaffar

et al. 2021

BioMed Research International

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Human bodies encompass very important symbiotic and mutualistic relationships with tiny creatures known as microbiota. Trillions of these tiny creatures including protozoa, viruses, bacteria, and fungi are present in and on our bodies. They play important roles in various physiological mechanisms of our bodies. In return, our bodies provide them with the habitat and food necessary for their survival. In this review, we comprehend the gut microbial species present in various regions of the gut. We can get benefits from microbiota only if they are present in appropriate concentrations, as if their concentration is altered, it will lead to dysbiosis of microbiota which further contributes to various health ailments. The composition, diversity, and functionality of gut microbiota do not remain static throughout life as they keep on changing over time. In this review, we also reviewed the various biotic and abiotic factors influencing the quantity and quality of these microbiota. These factors serve a significant role in shaping the gut microbiota population.

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“…Clinically, studies have shown that probiotics are involved in multiple phylogenetic and functional maturation, including nervous system and behavioral and cognitive functions [ 25 ]. In addition, many diseases, such as cardiovascular, autoimmune, neurodevelopmental diseases, including psychiatric disorders, have also been proved to be closely associated with probiotics [ 26 , 27 ]. In recent years, the focus of modern medicine has been increasingly focused on psychosocial aspects [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical Application Value of Lactobacillus Plantarum PS128 in Patients with Anxiety Disorders

Meng

Gao

et al. 2022

Clin Psychopharmacol Neurosci

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Objective: PS128 is a novel psycho biotic strain, it has been reported to play an important role in neuropsychiatric disorders. This study investigated the clinical effect of PS128 supplementation on patients with anxiety. Methods: A total of 200 patients with anxiety were recruited, and divided into two groups (n = 100/group). The control group received oral treatment with citalopram, and the PS128 group received PS128 capsules based on citalopram treatment. Hamilton Anxiety Scale (HAMA) and Self-Rating Anxiety Scale (SAS) were used to evaluate the anxiety levels. After 2 months of continuous administration, clinical efficacy was evaluated according to HAMA score. Results: There was no significant difference in HAMA and SAS scores between the two groups before treatment. With the treatment prolonged, the HAMA and SAS score decreased gradually in both control and PS128 groups, and the decrease rate of PS128 group was significantly greater than that of the control group. The clinical effective rates of PS128 group were higher than those in the control group, high levels of clinical cure rate were also detected in the PS128 group. Compared with the control group (22%), the incidence of adverse reactions was significantly reduced for patients in the PS128 group (4%). Conclusion: The treatment effect of citalopram combined with PS128 against anxiety is satisfactory clinically. It can greatly improve the anxiety symptoms of patients, increase the cure rate, reduce adverse reactions.

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Immunoregulatory Effects of Tolerogenic Probiotics in Multiple Sclerosis

Cited by 18 publications

References 125 publications

The Gut Microbiome in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS)

The Gut Microbiome in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS)

Biodiversity of Gut Microbiota: Impact of Various Host and Environmental Factors

Clinical Application Value of Lactobacillus Plantarum PS128 in Patients with Anxiety Disorders

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