Immunoregulation of cytokine signalling network in Toxoplasma gondii infectedwomen

Toxoplasmosis and Relation with Some Immunological Markers for Aborted Women in Thi-Qar Province

“…IRGs and GBPs are important for IFN-γ-induced anti-Toxoplasma responses. This study showed a highly significant difference compared to each other and the control group agreed with the studies of (Al- Khafajy, 2004;Hafedh et al, 2020). The cytokine network is controlled by a set of effective immune cells especially T cells, macrophages, and dendritic cells which release two types of cross-regulatory cytokines called pro-inflammatory and anti-inflammatory cytokines.…”

“…The cytokine signaling process also participates in the development of immunological memory and tolerance against invading pathogens. In Toxoplasma-aborted women, up regulation ofTh1 CD 4+ cells which is represented by increasing TNF-α and IFN-γ concentrations reflecting protective inflammatory responses against Toxoplasma infection (Hafedh et al, 2020).…”