Immunoreactivity of Kisspeptin and Kisspeptin Receptor in Eutopic and Ectopic Endometrial Tissue of Women With and Without Endometriosis

Abdelkareem, Amr O; Alotaibi, Fahad T; Alkusayer, Ghadeer M.; Ait-Allah, Abdou Saeed; Rasheed, Salah; Helmy, Yasser Ahmed; Allaire, Catherine; Peng, Bo; Yong, Paul J.

doi:10.1007/s43032-020-00167-w

Cited by 10 publications

(9 citation statements)

References 60 publications

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“…One study found lower levels of kisspeptin in endometrial stroma among patients with endometriosis than in controls (Abdelkareem et al, 2020 ), and another study found no difference between groups (Timologou et al, 2016 ). To the best of our knowledge, there are no data on serum kisspeptin in women with endometriosis, but under the diametric hypothesis, lower serum kisspeptin, with corresponding reductions in GnRH and LH secretion, is expected.…”

Section: Resultsmentioning

confidence: 99%

Endometriosis and polycystic ovary syndrome are diametric disorders

Dinsdale

Crespi

2021

Evolutionary Applications

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Evolutionary and comparative approaches can yield novel insights into human adaptation and disease. Endometriosis and polycystic ovary syndrome (PCOS) each affect up to 10% of women and significantly reduce the health, fertility, and quality of life of those affected. PCOS and endometriosis have yet to be considered as related to one another, although both conditions involve alterations to prenatal testosterone levels and atypical functioning of the hypothalamic-pituitary-gonadal (HPG) axis. Here, we propose and evaluate the novel hypothesis that endometriosis and PCOS represent

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Section: Resultsmentioning

confidence: 99%

Endometriosis and polycystic ovary syndrome are diametric disorders

Dinsdale

Crespi

2021

Evolutionary Applications

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“…They demonstrated that KISS1 and KISS1R levels are downregulated in eutopic endometrial stroma from women with endometriosis versus those without the disease. Moreover, deeply invasive lesions showed lower KISS1 levels than superficial lesions, and the authors concluded that downregulation of KISS1 may be associated with implant invasiveness [ 123 ].…”

Section: The Role Of Micrornamentioning

confidence: 99%

Molecular Mechanisms Underlying the Association between Endometriosis and Ectopic Pregnancy

Załęcka

Pankiewicz²,

Issat³

et al. 2022

IJMS

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Endometriosis is a common inflammatory disease characterized by the presence of endometrial cells outside the uterine cavity. It is estimated that it affects 10% of women of reproductive age. Its pathogenesis covers a wide range of abnormalities, including adhesion, proliferation, and cell signaling disturbances. It is associated with a significant deterioration in quality of life as a result of chronic pelvic pain and may also lead to infertility. One of the most serious complications of endometriosis is an ectopic pregnancy (EP). Currently, the exact mechanism explaining this phenomenon is unknown; therefore, there are no effective methods of prevention. It is assumed that the pathogenesis of EP is influenced by abnormalities in the contraction of the fallopian tube muscles, the mobility of the cilia, and in the fallopian microenvironment. Endometriosis can disrupt function on all three levels and thus contribute to the implantation of the embryo beyond the physiological site. This review takes into account aspects of the molecular mechanisms involved in the pathophysiology of endometriosis and EP, with particular emphasis on the similarities between them.

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“…Previous studies also revealed that kisspeptin expression varies in the glandular or stromal endometrial components in endometriosis. [ 80 , 82 , 83 ] The kisspeptin levels were lower in the eutopic endometrial glandular epithelium but similar in the stromal endometrium of women with endometriosis when compared to women without endometriosis. [ 80 ] Another study also reported that KISS1 expression was similar in stromal components from endometriosis lesions, eutopic endometrium, and healthy controls, but the expression was significantly lower in eutopic glandular endometrium than in ectopic lesions.…”

Section: Discussionmentioning

confidence: 99%

“…The tissue studies evaluating the kisspeptin and its receptor levels in deep, superficial, and ovarian endometriosis patients reported that deep lesions had lower levels of KISS1, thus, suggesting that kisspeptin might contribute to implant invasiveness. [ 83 ] When compared to SE, lower KISS1 levels were found in both glandular and stromal endometrium in deep and ovarian endometriosis, whereas lower KISS1R levels were observed in the glandular component of ovarian endometriosis. Additionally, comparisons of KISS1 and KISS1R between eutopic endometrium of endometriosis patients and normal endometrium of control patients revealed that endometriosis patients had decreased levels, which are concordant with previous studies.…”

Section: Discussionmentioning

confidence: 99%

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Serum kisspeptin levels in deep-infiltrating, ovarian, and superficial endometriosis: A prospective observational study

Önal

Karli²,

Özdemir

et al. 2022

Medicine

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The diagnosis of endometriosis may delay for many years due to non-deterministic symptoms and avoiding surgical interventions. Kisspeptins are hormones that interact with endometrial tissue to limit invasions during placentation and various cancers and are suggested to be also associated with endometriosis. This study evaluated if serum kisspeptin levels are associated with the invasion depth in endometriosis. Forty patients between 18 and 45 years of age and admitted to a tertiary-care Obstetrics and Gynecology Department between 2020 and 2021 with a diagnosis of endometriosis, and 40 patients without endometrioma were included in the study. Demographic, obstetric, clinical, and biochemical characteristics were evaluated in patients with superficial (SE) and deep infiltrating (DIE) endometriosis and healthy controls. Twenty patients (50%) had SE, 14 (35%) had DIE, and 22 (55%) had endometrioma in the patient group. Fertility rates were higher among controls, but similar between patients with SE and DIE. CA125 levels were significantly higher in the DIE group. SE and DIE groups had similar kisspeptin values, significantly higher than controls. CA125 and kisspeptin levels were not correlated in study groups. Serum kisspeptin levels were significantly different between endometriosis patients and healthy controls. However, kisspeptin levels were unable to differentiate endometriosis severity. Our results suggest that kisspeptins might play a role in the pathogenesis of endometriosis, which needs further assessment in more comprehensive studies.

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Immunoreactivity of Kisspeptin and Kisspeptin Receptor in Eutopic and Ectopic Endometrial Tissue of Women With and Without Endometriosis

Cited by 10 publications

References 60 publications

Endometriosis and polycystic ovary syndrome are diametric disorders

Endometriosis and polycystic ovary syndrome are diametric disorders

Molecular Mechanisms Underlying the Association between Endometriosis and Ectopic Pregnancy

Serum kisspeptin levels in deep-infiltrating, ovarian, and superficial endometriosis: A prospective observational study

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