Immunoreactive atrial natriuretic peptide in the thyroid gland

Sellitti, Donald F.; Hughes, Caitlin

doi:10.1016/0167-0115(90)90117-f

Cited by 15 publications

(9 citation statements)

References 18 publications

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“…Furthermore, proliferation of follicular cells from a solitary nodule was found to be independent of exogenous IGF-I, confirming the potential autocrine role of IGF-I in proliferative thyroid disease (Williams et al 1988). Cell culture studies of follicular cells from several species have shown that IGFs synergise with, and are obligatory for, the stimulatory effects of TSH on both thyroid growth and function (Eggo et al 1985, 1990, Ollis et al 1989, Williams et al 1988, whereas TSH alone is ineffective. The requirement for both TSH and IGF-I for follicular cell growth in vitro has subsequently been confirmed in vivo.…”

Section: Igfs Their Binding Proteins and Their Receptorsmentioning

confidence: 83%

“…ANP has been identified in human and pig thyroid follicular cells and is secreted basolaterally by pig thyroid cells in culture (Sellitti & Hughes 1990). High-affinity ANP receptors are found on human thyroid cells which (at least at high ANP concentrations) are coupled to the release of cGMP (Tseng et al 1990).…”

Section: ) and Frtl-5 Cells (Vainiomentioning

confidence: 99%

“…Progress in such studies has, to date, revealed evidence for an involvement of several autocrine growth stimulators and their receptors in the progression of MNTG. Prominent among these are the insulin-like growth factors (IGFs; Minuto et al 1989), fibroblast growth factors (FGFs; Thompson et al 1998), transforming growth factor 1 (TGF 1; Grübeck-Loebenstein et al 1989, Perlino et al 1996, hepatocyte growth factor (HGF; Eccles et al 1996), and the paracrine angiogenic factors, vascular endothelial growth factor (VEGF), placental-derived growth factor (PlGF) (Viglietto et al 1997) and endothelin (Sellitti & Hughes 1990).…”

Section: Introductionmentioning

confidence: 99%

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Growth factors and goitrogenesis

Bidey¹,

Hill²,

Eggo³

1999

Journal of Endocrinology

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By combining data from studies of multinodular non-toxic goitre (MNTG) with data from rat models of goitre induction and in vitro models, a map of the growth factors involved in goitrogenesis has been constructed. We have addressed the roles of the insulin-like growth factors, transforming growth factors, fibroblast growth factors, endothelins, etc. We hypothesise that an imbalance in the interactions between the various growth factor axes exists in MNTG which favours cell replication. Thyrotrophin, although not significantly elevated in MNTG, exerts critical effects through interactions with autocrine and paracrine factors and their receptors. Expansion of the thyroidal vascular bed through angiogenesis is closely co-ordinated with follicular cell expansion and folliculoneogenesis, and while the integrated paracrine actions of fibroblast growth factors, vascular endothelial growth factor and endothelin probably play central roles, additional, as yet elusive, factors are probably involved. The combination of in vitro and in vivo approaches, designed to address specific questions, will undoubtedly continue to prove invaluable in dissecting further the complex interactions that exist between these growth factors, their binding proteins and receptors in goitrogenesis.

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Section: Igfs Their Binding Proteins and Their Receptorsmentioning

confidence: 83%

Section: ) and Frtl-5 Cells (Vainiomentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Growth factors and goitrogenesis

Bidey¹,

Hill²,

Eggo³

1999

Journal of Endocrinology

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“…There have been a number of studies of ANP production in thyroid gland (7,9), but these have detected only a weak expression of ANP by immunofluorescence or the RT-PCR method. Although an immunofluorescence study showed that ANP production was detected in human thyroid follicular cells but not C cells (9), our data confirmed strong gene expression and production of ANP in rat thyroid medullary carcinoma, which is C cell neoplasm. Although it is difficult to reconcile these conflicting data, a change in C cell characteristics following carcinogenesis may be responsible.…”

Section: Resultsmentioning

confidence: 99%

Presence of Atrial Natriuretic Peptide in Rat Thyroid Medullary Carcinoma Cell Line

et al. 1998

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“…Atrial natriuretic peptide is stored in specific secretory granules in atrial and ventricular myocytes of several species (8,18,27). ANP-like immunoreactivity was also found in several extra-cardiac organs as central ncrvous system (12,23), adrenal medulla and sympathetic ganglia (10), salivary glands (4), sweat glands (25), thyroid gland (21), thymus (28), vena cava and pulmonary veins (15,26). ANP release by atrial myocytes seems to be directly correlated to atrial distension (13,19,20,24).…”

mentioning

confidence: 99%

Investigation of left atrial ANP-granule content and ANP release of isolated perfused rat heart.

Haug

Kohn

Metzele

et al. 1991

Acta Histochem. Cytochem

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Atrial natriuretic peptide (ANP) is known to be stored in specific secretory granules of cardiac myocytes. Atrial distension seems to be the major stimulus for ANP release. In the present study, we have investigated by means of light and electron microscopy and radioimmunoassay (RIA) left atrial ANPgranule content and ANP release of isolated rat heart, perfused with different left atrial pressures (5, 10, 15 and 20 cm H2O). Left atrial ANP-granule content was significantly reduced when left atrial pressure was elevated by perfusion volume expansion. There were no significant differences in ANP-granule content after perfusion with identical pressures over different time periods (20 min or 60 min). Measurement of ANP in the coronary effluent by RIA showed a significant pressure-dependent increase of ANP release, except for left atrial pressure elevation from 15 to 20 cm H2O, which did not result in a further increase of ANP release.

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Immunoreactive atrial natriuretic peptide in the thyroid gland

Cited by 15 publications

References 18 publications

Growth factors and goitrogenesis

Growth factors and goitrogenesis

Presence of Atrial Natriuretic Peptide in Rat Thyroid Medullary Carcinoma Cell Line

Investigation of left atrial ANP-granule content and ANP release of isolated perfused rat heart.

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