Abstract:Axon initial segments (AISs) are specialized neuronal compartments crucial for action potential generation and neuronal polarity. However, a detailed understanding of the mechanisms regulating AIS structure and function has been hindered by an incomplete knowledge of its molecular composition. Here, we profile the AIS proteome and its dynamic changes in-depth during neuronal maturation. Our method capitalizes on antibody targeted proximity labeling with subcellular spatial specificity in fixed primary neurons.… Show more
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