Immunoprophylaxis of Infectious Diseases in Russia: Condition and Perspective of Improvement

Брико, Н. И.; Фельдблюм, И. В.

doi:10.31631/2073-3046-2017-16-2-4-9

Cited by 18 publications

(3 citation statements)

References 10 publications

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“…Требуют совершенствования иммунологические исследования по оценке эффективности проводимой иммунопрофилактики, мониторинг поствакцинальных реакций и осложнений, изучению иммунологической структуры населения, слежению за скрытопротекающим эпидемическим процессом [3]. Существует необходимость специализированного обучения вопросов вакцинопрофилактики медицинских работников всех специальностей, в том числе в отношении нежелательных явлений в поствакцинальном периоде [6].…”

Section: обсуждение и выводыunclassified

“…До 25% детей до 2-х лет не получают законченный курс иммунизации против коклюша. Неуспех элиминации кори напрямую зависит от недостаточного охвата населения прививками [3]. С 2010 г. нача-лась работа по подготовке к сертификации территории РФ как свободной от кори [9].…”

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Surveying children and adult vaccination program against diphtheria, tetanus, measles and viral hepatitis B in the Russian Federation

Галина¹,

Миндлина²,

Полибин³

2019

Russian Journal of Infection and Immunity

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Over the last years, incidence of vaccine-preventable infections tended to increase both in Russia and multiple European countries due to diverse reasons, including loss of alertness in medical workers to ensure proper quality of immunization. Currently, vaccination is considered to be the most efficient means for preventing infectious diseases. However, vaccination efficacy is directly related to population coverage and proper timeframe for its application.Materials and methods. Diphtheria, tetanus, measles and hepatitis B vaccination coverage and timeframe were analyzed for population of Russia, Moscow as well as the three pediatric and adult out-patient hospitals.Results. It was found that compared to adults, pediatric subjects were vaccinated better. However, in case of 95% or higher coverage against all infections, shortcomings in vaccination timeframe were uncovered. In 2017, despite pediatric subjects should be vaccinated against diphtheria and tetanus at the age of 3-to-6 months, coverage was as low as 46.9% in Russia, 48.7% in Moscow that ranged in some polyclinics from 21.8% in 2012 down to 1.7% in 2017. Moreover, this situation was even more unfavorable in case of revaccination program. In particular, it was found that at the age of 18 months only 50, 54, and 49–55% underwent revaccination in the Russia, Moscow 54%, and some out-patient hospitals, whereas at the age of 7–14 years in Russia there were revaccinated up to 97% population. Likewise, at the age of 6 months there were covered with vaccination against hepatitis B as few as 49% population in Russia and Moscow, whereas more than 90% coverage was achieved only at the age of 1 year. Immunization coverage reaching more than 85% of adult population against hepatitis B is superior to diphtheria and tetanus. Immunization coverage against measles in Russia at all age groups was over 90% population. Thus, it is necessary to optimize activities on adhering to vaccination timeframe, as decline in quality of vaccination inevitably leads to elevated incidence rate of vaccine-preventable infections. This and vaccination coverage might be adjusted by introducing a Preventive Vaccination Surveillance and Reporting Automated System in the Russian Federation.

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Section: обсуждение и выводыunclassified

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Surveying children and adult vaccination program against diphtheria, tetanus, measles and viral hepatitis B in the Russian Federation

Галина¹,

Миндлина²,

Полибин³

2019

Russian Journal of Infection and Immunity

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“…Ежегодно повторяющиеся сезонные подъёмы заболеваемости острыми респираторновирусными инфекциями (ОРВИ), среди которых лидирует грипп, приводят к необходимости ежегодной противогрип позной вакцинации населения. Для формирования и поддержания популяционного иммунитета требует ся выполнение значительных объёмов вакцинации [1][2][3]. Так как не все жители согласны вакцини роваться, то между администрацией (Федеральной службой Роспотребнадзора) и населением возни кает напряжённость отношений.…”

Section: Introductionunclassified

Effectiveness Analysis of a Compromise Approach to Solving the Problem of Refusal of Influenza Vaccination

Kolesin

Zhitkova

2023

Epidemiology and Vaccinal Prevention

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Relevance. The ineffectiveness of current methods of engaging the population in vaccine prophylaxis leads to the need to develop new means of solving the problem of vaccination abandonment.Aims is to show the effect of applying the theory of compromise solutions to the analysis of the problem of refusal of influenza vaccination.Materials and methods. Data on number of vaccinated and morbidity among vaccinated and unvaccinated; the research method is based on the compilation of criteria reflecting the interests of the administration and the population, followed by finding a compromise solution and evaluating it using an indicator of tensions.Results. Based on data on morbidity among vaccinated and unvaccinated, the existence of an optimal percentage of vaccinated for the adult population and for each of the three risk groups is shown: medical staff, service employees and persons over 60 years of age; on the example of the group «persons over 60 years of age», the possibility of reducing tension in the case of replacing a single vaccination with a complex one is shown.Conclusion. The effectiveness of the application of the theory of compromise solutions to the assessment of tensions between the sanitary and epidemiological inspection service and the population in terms of vaccination is presented; the possibility of reducing tension by switching to complex immunoprophylaxis is presented.

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Evaluation of Post-Vaccination Immunity in Children and Adolescents after Viral Hepatitis B Vaccine

Khamidulina,

Solovеva,

Kostinov

et al. 2024

Pediatr. farmakol.

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Vaccination against viral hepatitis B is an effective method of protection against this infection. There is multiple decrease in the hepatitis B incidence. However, there was increase in chronic hepatitis B by 42.5%, 15 cases of acute viral hepatitis B in children and 2 deaths from this infection were registered according to the state report “On the sanitary and epidemiological wellbeing of the population of the Russian Federation for 2022”. The criteria for evaluating protection against viral hepatitis B are the anti-HBs level and the duration of post-vaccination immunity.Objective. The aim of the study is to evaluate the duration of postvaccination immunity in temporal aspect in children and adolescents vaccinated against viral hepatitis B.Methods. Prospective open-label study was conducted to assess post-vaccination immunity against viral hepatitis B in 143 children and adolescents. The study of anti-HBs was implemented via the immunoenzyme test system “Vectohep B-HBs-antigen”. Microsoft Office Excel 2010 package and the Prism9 program (GraphPad, USA) were used for statistical analysis.Results. It has been shown that hepatitis B vaccine provides 100% seroconversion. However, decrease in anti-HBs levels was revealed already 6 months after vaccination in 15.07% of cases of seronegative individuals, after 1 year their number has increased up to 28.77% of cases. On average, every fourth person had low protective level of anti-HBs. Almost two-thirds of adolescents became seronegative by the age of 14.Conclusion. Vaccination against viral hepatitis B ensures the maximum production of anti-HBs 1 month after the completed vaccination in 100% of cases. Antibody level begins to decrease 6 months after the third completed vaccination against hepatitis B, and in 14 years, 72.74% of those immunized become seronegative. All of these dictates the need to consider a booster dose in adolescents at the age of 14 years.

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Immunoprophylaxis of Infectious Diseases in Russia: Condition and Perspective of Improvement

Cited by 18 publications

References 10 publications

Surveying children and adult vaccination program against diphtheria, tetanus, measles and viral hepatitis B in the Russian Federation

Surveying children and adult vaccination program against diphtheria, tetanus, measles and viral hepatitis B in the Russian Federation

Effectiveness Analysis of a Compromise Approach to Solving the Problem of Refusal of Influenza Vaccination

Evaluation of Post-Vaccination Immunity in Children and Adolescents after Viral Hepatitis B Vaccine

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