Immunoproliferative small intestinal disease in algerians. I. Light microscopic and immunochemical studies

Asselah, F.; Slavin, G; Asselah, H.

doi:10.1002/1097-0142(19830715)52:2<227::aid-cncr2820520208>3.0.co;2-2

Cited by 35 publications

(2 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Following these reports, Rambaud and Halphen [8] proposed that the term 'IPSID' should be used for all cases that have the same pathological lesions as a-CD irrespective of the type of immunoglobulin the proliferative cells may synthesize. According to this view, cases of IPSID can be further divided into three subgroups: IPSID with synthesis and secretion of alpha heavy chains, which is the most common form called a-CD [5][6][7][8]; IPSID with synthesis but without the secretion of alpha heavy chains called non-secretory a-CD [9,10]; IPSID with synthesis or secretion of other monoclonal immunoglobulins, free light chains or polyclonal IgA (non-a-CD IPSID) [11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

“…The majority of IPSID cases have come from Israel [1,2], northern Africa [15,28,29], and other middle eastern and Mediterranean countries [30][31][32]. However, the disease is not confined to this particular geographical area, as numerous cases have been reported from the Indian subcontinent, the Far East, central and sub-Saharian Africa, and central and south America [26,32].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Immunoproliferative small intestinal disease in Greece: presentation of 13 cases including two from Albania

Economidou¹,

Manousos²,

Triantafillidis³

et al. 2006

European Journal of Gastroenterology & Hepatology

View full text Add to dashboard Cite

The patients were categorized in three subgroups of IPSID: alpha-chain disease (n=8), non-alpha chain disease with other monoclonal immunoglobulins (n=3), and polyclonal 'non-malignant' IPSID (n=2). In several patients the disease had unusual features, and this in some cases delayed the diagnosis. In suspected cases it is thus of the utmost importance to proceed to an exploratory laparatomy. Patients with stage C disease had a short survival, whereas two patients with stage A alpha-chain disease responded to treatment with cyclophosphamide, vincristine and prednisolone, and cyclophosphamide, doxorubicine, vincristine and prednisolone, respectively, have a disease-free long survival of 35 and 12 years, and appear to be cured.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Immunoproliferative small intestinal disease in Greece: presentation of 13 cases including two from Albania

Economidou¹,

Manousos²,

Triantafillidis³

et al. 2006

European Journal of Gastroenterology & Hepatology

View full text Add to dashboard Cite

show abstract

Immunoproliferative small intestinal disease in algerians. II. Ultrastructural studies in alpha‐chain disease

Crow

Asselah

1984

Cancer

Self Cite

View full text Add to dashboard Cite

The plasma cell infiltrate of the small intestine in alpha‐chain disease has been studied ultrastructurally in an attempt to determine whether there is a significant nuclear‐cytoplasmic asychrony that could be used as evidence for the neoplastic nature of the disease, even in its early stages. No such asynchrony was identified. In the early stages of the disease, the infiltrate was mainly of slightly immature plasma cells indistinguishable from those of coeliac disease. Later stages were marked by the presence of less differentiated immunoblastic cells arising in the deep mucosa and infiltrating into glands. Multinucleate plasmacytoid cells were thought to be degenerate cells. The significance of these findings is discussed in relation to the nature of alpha‐chain disease and immunoproliferative small intestinal disease in general.

show abstract

Non-Hodgkin's lymphomas in the Middle East. A study of 417 patients with emphasis on special features

Salem

Anaissie

Allam

et al. 1986

Cancer

View full text Add to dashboard Cite

A total of 417 evaluable patients with non-Hodgkin's lymphomas were diagnosed between January 1974 and December 1983 at the American University of Beirut Medical Center in Beirut, Lebanon. Of these, 179 (43%) patients had nodal lymphomas, and 183 (44%) had extranodal lymphomas. The commonest lymphoma was diffuse large cell (27%), followed by large cell immunoblastic (21%). The histopathologic pattern was follicular in 18% of the nodal lymphomas and in 5.3% of the extranodal forms. The most common site of extranodal lymphoma was the gastrointestinal tract (46.5%), followed by Waldeyer's ring (19%). Small intestinal lymphomas were three times more common than gastric lymphomas. Immunoproliferative small intestinal disease (IPSID) was diagnosed in 20 of 59 patients who had primary small intestinal lymphoma. Of the 34 patients who had Waldeyer's ring lymphoma, 7 had gastrointestinal involvement at some time during the course of the disease. Nodal lymphomas were associated with poor prognostic factors: 82% were diffuse; 77% had advanced disease at presentation; 77% had intermediate- or high-grade malignancy lymphoma; 40% had marrow involvement; and 46% had B symptoms. In children, the most common lymphoma was Burkitt's, and 80% of pediatric lymphomas were high-grade malignancy. In conclusion, this study delineates the special features of non-Hodgkin's lymphomas in the Middle East: The presence of IPSID; the high incidence of extranodal forms, in particular the intestinal ones; and the rarity of follicular lymphomas.

show abstract

Immunoproliferative small intestinal disease in algerians. I. Light microscopic and immunochemical studies

Cited by 35 publications

References 33 publications

Immunoproliferative small intestinal disease in Greece: presentation of 13 cases including two from Albania

Immunoproliferative small intestinal disease in Greece: presentation of 13 cases including two from Albania

Immunoproliferative small intestinal disease in algerians. II. Ultrastructural studies in alpha‐chain disease

Non-Hodgkin's lymphomas in the Middle East. A study of 417 patients with emphasis on special features

Contact Info

Product

Resources

About