Immunopotentiating effect of proton pump inhibitor pantoprazole in a lymphoma-bearing murine host: Implication in antitumor activation of tumor-associated macrophages

The acidic microenvironment as a possible niche of dormant tumor cells

“…Inhibition of proton pumps on tumor cells with pantoprazole, another PPI, hampers tumor-induced suppression of macrophages both in vitro and in vivo [94,95]. Finally, neutralization of tumor pH with bicarbonate impairs the growth of cancer in mice, and this effect was associated with an increased T-cell infiltration in tumor masses [96].…”

Pigment Epithelium-derived Factor (PEDF) Promotes Tumor Cell Death by Inducing Macrophage Membrane Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)

“…TAMs are considered an attractive target for therapeutic intervention. These proposed strategies include activation of TAMs to a tumoricidal state (17)(18)(19), repression of the tumor-supportive activities of TAMs (20), and depletion of TAMs (21)(22)(23). A recent animal study showed that overexpression of PEDF in a rat prostate tumor by transient transfection of a PEDF-expressing plasmid caused increased macrophage recruitment and expression of inducible nitric-oxide synthase in macrophages (12).…”

The influence of flavonoids on the binding of pantoprazole to bovine serum albumin by spectroscopic methods: With the viewpoint of food/drug interference

“…1) is the third proton pump inhibitor to be developed for the treatment of gastritis and duodenal ulcer. Up to now, most reports have focused on the pharmacokinetics, metabolism and clinical relevance about pantoprazole (Bardou & Martin, 2008;Raffin et al, 2010;Smith et al, 2010;Vishvakarma & Sigh, 2010). However, to our best knowledge, the interactions of pantoprazole with serum albumin have not been reported.…”