Immunophenotyping of male breast cancer - Experience at a tertiary care centre

Pasricha, Sunil; Kamboj, Meenakshi; Tanwar, Parul; Gupta, Gurudutt; Panigrahi, Manoj Kumar; Sharma, Abhimanyu; Durga, Garima; Mehta, Anurag

doi:10.4103/ijpm.ijpm_543_18

Cited by 2 publications

(6 citation statements)

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“…Axillary involvement is present in approximately 30-50% of the cases at the time of diagnosis ( 2 , 14 ) and was present in 9/27 (33%) of our cases. Most male breast cancers are usually positive for ER (65-97%) and PR (60-85%) ( 2 , 4 , 13 , 14 , 22 , 23 ). The Her2/neu positivity rate is 3-28% ( 14 , 22 , 24 ).…”

Section: Discussionmentioning

confidence: 59%

“…Among male breast cancers, IC-NST (80-90%) is the most common histopathological diagnosis followed by papillary carcinomas. Less often, ILC, mucinous carcinoma and apocrine carcinoma are detected ( 8 , 14 ). In our series, 23 IC-NST, two ILC, one IMPC with apocrine features, and one mixed carcinoma (IC-NST with cribriform carcinoma) were observed, consistent with the literature.…”

Section: Discussionmentioning

confidence: 99%

“…In our study, 14 cases were grade 3 (51.9%) and 11 cases were grade 2 (40.7%). In a few studies, the median survival has been shown to be significantly poor in high-grade (grade 3) tumors ( 14 ). However, no such significant correlation was seen between tumor grade and outcome (p= 0.65) in our study.…”

Section: Discussionmentioning

confidence: 99%

“…Most male breast cancers are usually positive for ER (65-97%) and PR (60-85%) ( 2 , 4 , 13 , 14 , 22 , 23 ). The Her2/neu positivity rate is 3-28% ( 14 , 22 , 24 ). The rate of triple-negative breast carcinoma varies between 3 and 19% ( 14 , 24 ).…”

Section: Discussionmentioning

confidence: 99%

“…However, its incidence has recently been increasing with approximately 2000 to 2500 new cases reported annually in the United States (1,3,(8)(9)(10)(11)(12). Although male breast cancer occurs in all age groups, it is frequently observed between 60 and 70 years of age on average (2,3,10,(12)(13)(14). Genetic factors, BRCA2 mutations, family history, obesity, Klinefelter's syndrome, gynecomastia, liver disease, orchitis, undescended testicle, alcohol use, exogenous estrogen and testosterone use, and radiation are accused in the etiology (1,8,9,(15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

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Male breast cancer: clinicopathological, immunohistochemical and radiological study

Hasbay

Bolat²,

Aytaç³

et al. 2020

TJPATH

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Objective: To evaluate the pathological and radiological features, immunohistochemical profile and treatment methods of primary male breast carcinoma cases diagnosed at our center. Material and Method: The pathology archive between 2006 and 2019 was reviewed and the data of 27 male patients diagnosed as primary breast cancer were retrospectively evaluated. Results: The age of the patients ranged between 40-86 years. The left breast was involved in 17 patients. The mean tumor diameter was 2.35 ± 1.09 cm. Of the 27 cases, 8 were dead and 19 were alive. The mean follow-up duration was 37.45 ± 24.84 months. The mean estimated life expectancy was 65±14.7 months. The most common complaint was a swelling in the breast. The time interval between the onset of complaints and admittance to hospital ranged from three months to two years. The most common histopathological diagnosis was invasive carcinoma-no special type. The most common surgical procedure was mastectomy with lymph node dissection. Nine patients had metastatic lymph nodes. In terms of the hormone profiles, 24 were Estrogen receptor positive, 21 were Progesterone receptor positive and six were Her2/neu positive. Three patients had triple-negative tumors. Conclusion: Male breast carcinoma is a rare disease but its frequency has been increasing recently. As breast cancer is more commonly attributed to women, the diagnosis is usually delayed until later stages in males. Public awareness should therefore be increased and breast cancer should be considered in the differential diagnosis especially in the presence of breast swelling and complaints related to the breast skin so that the appropriate biopsy can be obtained without delay.

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