Immunophenotypic profile of CNS lymphoma: A review of eighteen cases

Bashir, Rifaat; Freedman, AS; Harris, Nancy L.; Bain, K. M.; Nadler, Lee M.; Hochberg, Fred H.

doi:10.1007/bf00172918

Cited by 29 publications

(8 citation statements)

References 39 publications

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“…The percentage of each subtype varies from 1 series to another. 5,618 Some papers have reported a high percentage of unclassified cases and emphasized the pleomorphism of PCNSLs. 6,18 The Revised European-American Lymphoma classification 10 pointed out the difficulty of reproducing the diagnoses of these subtypes; therefore, classification of these tumors as diffuse large B-cell lymphomas was considered optimal because these lymphomas require the same treatment.…”

Section: Discussionmentioning

confidence: 99%

Primary Central Nervous System Lymphomas in 72 Immunocompetent Patients: Pathologic Findings and Clinical Correlations

Camilleri-Broët

Martin

Moreau³

et al. 1998

Am J Clin Pathol

154

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A b s t r a c tRecent studies suggest that the incidence of primary central nervous system lymphomas (PCNSLs) is increasing. A few decades ago, PCNSLs accounted for only 1% of all primary intracranial neoplasms. Today, however, they represent between 2% and 6% of all primary brain neoplasms and more than 1% of all non-Hodgkin lymphomas. This trend does not seem totally explained by improved diagnostic techniques or by HIV infection. A substantial increase in PCNSLs among immunocompetent patients has been observed.'"* Most PCNSLs are characterized by a diffuse proliferation of large B cells. 7 Follow-up usually shows a rapid local relapse. Systemic dissemination has been described only rarely. The prognosis remains poor even though some long-term survival has been reported. 38The frequency of each histologic subtype is variable from 1 series to another, and little is known about their biologic characteristics. In a previous article, 9 we reported the major features of 51 AIDS-related PCNSLs. In the present study, we reviewed 72 PCNSLs occurring in immunocompetent patients and studied their clinical and morphologic characteristics, immunophenotype (including expression of bcl-2 and p53), and Epstein-Barr virus (EBV) status. We also studied the impact of these different variables on patient survival. Material and Methods PatientsSeventy-two PCNSLs were studied, including 40 in patients who were part of the lymphomes cerebraux primitifs

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Section: Discussionmentioning

confidence: 99%

Primary Central Nervous System Lymphomas in 72 Immunocompetent Patients: Pathologic Findings and Clinical Correlations

Camilleri-Broët

Martin

Moreau³

et al. 1998

Am J Clin Pathol

154

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“…3 Its tropism for the CNS, which remains largely unexplained, and low rates of systemic dissemination logically led to the use of radiotherapy alone as definitive management. [5][6][7][8][9] Despite doses of radiotherapy that would be expected to control most non-Hodgkin's lymphomas at other sites, local failure was extremely common. 10 This propensity for local recurrence was best demonstrated in a large phase II study performed by the Radiation Therapy Oncology Group, in which doses of 50 to 60 Gy were delivered to macroscopic disease.…”

Section: P Rimary Cns Lymphoma (Pcnsl) Has Attractedmentioning

confidence: 99%

Phase II Multicenter Study of Brief Single-Agent Methotrexate Followed by Irradiation in Primary CNS Lymphoma

O’Brien

Roos

Pratt

et al. 2000

JCO

215

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P h a s e I I M u l t i c e n t e r S t u d y o f B r i e f S i n g l e -A g e n t M e t h o t r e x a t e F o l l o w e d b y I r r a d i a t i o n i n P r i m a r y C N S L y m p h o m aBy P. O'Brien, D. Roos, G. Pratt, K. Liew, M. Barton, M. Poulsen, I. Olver, and G. TrotterPurpose: To assess, in a multi-institutional setting, the impact on relapse, survival, and toxicity of adding two cycles of intravenous methotrexate to cranial irradiation for immunocompetent patients with primary CNS lymphoma.Patients and Methods: Forty-six patients with a median age of 58 years and Eastern Cooperative Oncology Group performance status 0 to 3 were entered onto this phase II study. The protocol consisted of methotrexate 1 g/m 2 on days 1 and 8 followed by cranial irradiation on day 15. A whole-brain dose of 45 Gy was followed by a boost of 5.4 Gy. Intrathecal chemotherapy and spinal irradiation were given only to patients for whom cytologic examination of CSF was positive for CNS lymphoma. The median follow-up time was 36 months, with a minimum potential follow-up of 12 months.Results: Median survival was 33 months, with 2-year probability of survival 62% ؎ 15% (95% confidence interval). Twenty patients have relapsed. The predominant site of relapse was the brain. Neither performance status nor age was found to influence survival. Six patients developed a dementing illness at a median of 16 months after treatment, and three of these died as a consequence.Conclusion: A brief course of intravenous methotrexate before cranial irradiation is associated with 2-year and median survival rates superior to those reported for radiotherapy alone and similar to more intensive combined-modality regimens. Neurotoxicity remains an important competing risk for these patients.

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“…Unfortunately, we did not use Southern blot analysis to examine the change of clonality ofATLcells at the time of CNSinvasion. Generally, infiltration of the CNS is rare in PTCL, and most lymphomas involving the CNS are of B-cell lineage (25). However, NCAM-positive PTCL has been reported to frequently involve the CNS.…”

Section: Discussionmentioning

confidence: 99%

Adult T-cell Leukemia (ATL) Cells which Express Neural Cell Adhesion Molecule (NCAM) and Infiltrate into the Central Nervous System.

et al. 2002

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Weencountered a patient with adult T-cell leukemia/lymphoma (ATL) which expressed neural cell adhesion molecule (NCAM). The tumor cells markedly infiltrated the central nervous system (CNS) during the course of the ATL. The patient died 20 months after disease onset, which was considered to be early in the course. During the invasion of the CNS, the surface phenotype of the peripheral blood ATL cells by flow cytometric analysis was CD2+, CD3+, CD4+, CD7-, CD8-, CD16-, NCAM(CD56)+, HLA-DR-. We speculate that the infiltration ofATLcells into the CNSwas closely related to the expression of the NCAM in this patient. (Internal Medicine 41 : 34-38, 2002)

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Immunophenotypic profile of CNS lymphoma: A review of eighteen cases

Cited by 29 publications

References 39 publications

Primary Central Nervous System Lymphomas in 72 Immunocompetent Patients: Pathologic Findings and Clinical Correlations

Primary Central Nervous System Lymphomas in 72 Immunocompetent Patients: Pathologic Findings and Clinical Correlations

Phase II Multicenter Study of Brief Single-Agent Methotrexate Followed by Irradiation in Primary CNS Lymphoma

Adult T-cell Leukemia (ATL) Cells which Express Neural Cell Adhesion Molecule (NCAM) and Infiltrate into the Central Nervous System.

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