Immunophenotypic Characterization of an Unusual T-Cell Lymphoma Presenting as Anterior Uveitis

Goldey, Stacia H.; Stern, George A.; Oblon, David J.; Mendenhall, Nancy P.; Smith, Linda J.; Duque, Ricardo E.

doi:10.1001/archopht.1989.01070020419047

Cited by 56 publications

(24 citation statements)

References 27 publications

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“…1 Rare subtypes include T-cell-rich B-cell lymphoma 58 and T-cell lymphoma. [59][60][61][62] VRL are characterized by a subretinal or perivascular retinal infiltration of pleomorphic medium-to-large sized cells with minimal basophilic cytoplasm, indented or folded nuclei, and prominent, often multiple, nucleoli. These changes can be quite discreet (Figure 3).…”

Section: Vitreoretinal Lymphomamentioning

confidence: 45%

Molecular pathology of lymphoma

Coupland

2012

Eye

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Ocular lymphomas can be divided into intraocular lymphomas and ocular adnexal lymphomas. The vitreoretinal lymphomausually a diffuse large B-cell lymphoma (DLBCL) of high-grade malignancy-is the most common lymphoid malignancy arising in the eye, while the extranodal marginal zone B-cell lymphoma (EMZL), an indolent often recurrent tumour, occurs most frequently in the ocular adnexal tissue. The two lymphoma subtypes differ significantly in their clinical presentation, subsequent course and outcome as well as in their underlying morphological, immunophenotypical and genetic features. The molecular processes involved in DLBCL and EMZL development are complex, and include chromosomal translocations, mutations caused by aberrant somatic hypermutation, sporadic somatic mutations, and copy number alterations, characterized by deletions and amplifications. These lead to alterations in particular signalling pathways, which in turn activate transcription factors, such as nuclear factor NF-kB. This review provides an overview of the histological features of DLBCL and EMZL, and discusses the current insights into the molecular mechanisms underlying the development of these tumours, when they occur systemically and particularly when they arise in ocular tissues.

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Section: Vitreoretinal Lymphomamentioning

confidence: 45%

Molecular pathology of lymphoma

Coupland

2012

Eye

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“…According to the literature, those patients with an intraocular lymphomatous manifestation with underlying mycosis fungoides usually have a relatively long history of cutaneous lymphoma (median 7 years), and died within weeks to months of developing intraocular lymphoma [22,23,25,32,42,47,49,69,70]. Of those with systemic (non-mycosis) T-cell lymphoma, the majority of reported patients died within a year after diagnosis of intraocular disease, although exceptional cases have been described (up to 95 months survival) [6,10,18,32,33,35,38,44,57,61,72]. In two of the three described cases of intraocular T-cell lymphoma without systemic or CNS lymphoma the patients were alive, with follow-up of 6 and 18 months, at the time of reporting [6,10].…”

Section: Discussionsupporting

confidence: 40%

“…Very few cases of T-cell-related primary intraocular lymphoma (T-PIOL) without any association with mycosis fungoides have been reported [33,38,48]. We present a case of T-PIOL with demonstration of a monoclonal rearrangement of the T-cell-receptor gamma (TCR-γ) gene.…”

Section: Introductionsupporting

confidence: 44%

Primary intraocular lymphoma of T-cell type: report of a case and review of the literature

Coupland

Anastassiou

Bornfeld

et al. 2004

Graefe's Arch Clin Exp Ophthalmol

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A rare PIOL of T-cell type was diagnosed on the basis of vitreous aspiration and chorioretinal biopsy. In addition to conventional cytology and immunocytology, the utilisation of gene rearrangement studies on vitreous or chorioretinal biopsies increases the chances of diagnosing or excluding a PIOL of either B-cell or T-cell type. Despite its rarity, ophthalmic pathologists should always consider the diagnosis of T-PIOL when reviewing vitreous samples.

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“…Of 23 published cases with clinical data, [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] nine (39%) were associated with mycosis fungoides (primary T-cell malignancy of skin), 20,24,25,27,[29][30][31][32]34,35 10 (43%) with systemic (nonmycosis) lymphoma, [17][18][19]22,23,[26][27][28]33 two (9%) with CNS and intraocular lymphoma only, 17,20 and two (9%) were restricted to the eye only. 18,21 Therefore, systemic disease is found in 82% of patients with T-cell intraocular This was the total dose administered to the cranial vault and orbits.…”

Section: Discussionmentioning

confidence: 99%

Intraocular lymphoma: a series of 14 patients with clinicopathological features and treatment outcomes

Hoffman

McKelvie

Hall

et al. 2003

Eye

137

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Aims To assess the clinical features, pathology, mortality (systemic outcome) and ocular complications (visual outcome) of a cohort of patients treated for intraocular lymphoma. Methods Retrospective case analysis of medical records and review of pathology of a consecutive series of patients presenting with intraocular lymphoma in Melbourne over 11 years between 1990 and 2000. Categorical factors influencing survival were examined by the Kaplan-Meier estimator and groups compared with the log rank test.

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Immunophenotypic Characterization of an Unusual T-Cell Lymphoma Presenting as Anterior Uveitis

Cited by 56 publications

References 27 publications

Molecular pathology of lymphoma

Molecular pathology of lymphoma

Primary intraocular lymphoma of T-cell type: report of a case and review of the literature

Intraocular lymphoma: a series of 14 patients with clinicopathological features and treatment outcomes

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