Immunophenotypic Analysis of Acute Leukemia

Traweek, S. Thomas

doi:10.1093/ajcp/99.4.504

Cited by 43 publications

(26 citation statements)

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“…B-cell antigen expression was almost exclusively CD19, and was predominantly seen in AML-M1. Kita et al showed an association between CD19 expression and AML-M2, and also has been linked with a specific cytogenetic abnormality, the t (8; 21) translocation [45]. CD19 has been associated previously with AML-M5, but one case was detected in our study in AML-M1 subtype.…”

Section: Acute Myeloid Leukemia (Aml)contrasting

confidence: 41%

“…Most cases will express more than one T-lineage marker Aberrant deletion of one or more pan T-cell antigens is common in this disease, however, and maybe a helpful diagnostic finding. T early phenotype: leukemic cells express cCD3 as well as any other pan T marker (CD7, CD5, or CD2), The threshold of positivity was considered 20% for all markers except for CD10, CD34 and TdT, ALL the 5 cases of T-ALL showed deletion of one or more of the 4 Pan T-cell antigens used (CD2, CD3, CD5 and CD7) [45].…”

Section: Acute Lymphoblastic Leukemia (All)mentioning

confidence: 99%

“…The CD3 antigen is expressed on 61% to 85% of normal peripheral blood lymphocytes 65% to 85% of thymocytes and on Purkinje cells in the cerebellum [44].CD7 is also the antigen that is most commonly deleted in these acute leukemias [45].…”

Section: Acute Lymphoblastic Leukemia (All)mentioning

confidence: 99%

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Immunophenotypic Profile in Adult Patients with Acute Leukemia Association with Clinical Feature: Fluorescence Cytometry Quantitative Analysis

Elbossaty¹

2017

J Mol Biomark Diagn

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Antigen surface markers represent as the new prognostic tool for detection of acute leukemia. To investigate the prevalence expression of lymphoid and myeloid antigen lineage in acute leukemias. This study included 100 acute leukemias patients. Specimens were selected from consecutive patients who had sufficient material available. Among the 100 patients in which a detailed history, hematological, clinical and immunophenotyping analysis were performed. This study was showed distribution of immunophenotyping characters between studied AML and ALL cases. The most abundant immunophenotyping features in acute myeloid leukemia were cMPO, CD33, CD117, CD13, CD14 and CD64, while the most abundant immunophenotyping features in acute lymphoblastic leukemia were CD19, CD79a, TdT, CD20, CD10 and CD34. cMPO which act as independent prognostic factor for AML, CD10 and TdT can used as independent prognostic factor for differentiate between ALL and AML.

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Section: Acute Myeloid Leukemia (Aml)contrasting

confidence: 41%

Section: Acute Lymphoblastic Leukemia (All)mentioning

confidence: 99%

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Immunophenotypic Profile in Adult Patients with Acute Leukemia Association with Clinical Feature: Fluorescence Cytometry Quantitative Analysis

Elbossaty¹

2017

J Mol Biomark Diagn

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“…GVHD decreased highest in B lineage ALL and less or absent in T lineage ALL. [14][15][16][17][18] It is thus plausible that the antileukemia effect relapse risks to a similar extent in T and B lineage ALL. For first remission transplants, relative risks of relapse of GVHD might occur preferentially in the HLA class IIbearing B lineage leukemias.…”

Section: Discussionmentioning

confidence: 99%

Graft-versus-leukemia effects in T lineage and B lineage acute lymphoblastic leukemia

Passweg

Tiberghien²,

Cahn

et al. 1998

Bone Marrow Transplant

114

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Summary:Allogeneic bone marrow transplantation is an effective treatment for acute lymphoblastic leukemia (ALL). 1 This efficacy is, in part, mediated by graft-versus-leukemia T and B lineage ALL cells express different levels of HLA-class II antigens, which may serve as targets for effects (GVL). 2,3 GVL is greatest in patients with acute or chronic graft-versus-host disease (GVHD). T cells are graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL). The object of this study was to determine important in GVHD; 4 removing T cells from donor bone marrow greatly reduces the incidence and severity of whether GVL effects after HLA-identical sibling bone marrow transplantation differed in T and B lineage GVHD but increases the relapse risk. Different leukemias respond differently to GVL. The rea-ALL. We studied 1132 patients with ALL of T lineage (n = 416) or of B lineage (cALLa + ) (n = 716) transson for this is uncertain. Molecules on the surface of leukemia cells may determine susceptibility to GVL. 6 In experiplanted in first (n = 605) or second (n = 527) remission with bone marrow from an HLA-identical sibling mental models, major histocompatibility complex (MHC) class I expression is needed for a CD8 + T lymphocyte donor, between 1982 and 1992, and reported to the IBMTR by 165 teams. Cox proportional hazards response whereas MHC class II is required for both initiating the immune response and serving as a target for cytoregression models were used to determine the relative risk (RR) of relapse in patients with acute (grades IItoxic CD4 + T lymphocytes. [7][8][9][10][11] Experimental data suggest that alloreactive CD4 + lymphocytes are able to kill leuke-IV) or chronic GVHD vs patients without GVHD. Acute and chronic GVHD were considered as time-dependent mia cells. 12,13 In ALL, class II antigen expression (HLA-DR) differs significantly among leukemia phenotypes; it is covariates. Patients transplanted in first and second remission were analyzed separately. GVHD decreased highest in B lineage ALL and less or absent in T lineage ALL. [14][15][16][17][18] It is thus plausible that the antileukemia effect relapse risks to a similar extent in T and B lineage ALL. For first remission transplants, relative risks of relapse of GVHD might occur preferentially in the HLA class IIbearing B lineage leukemias. The object of this study was for patients with vs those without GVHD was 0.34 for T lineage ALL and 0.44 for B lineage ALL. Correspondto address this question by comparing the effects of GVHD on relapse rates in B lineage and T lineage ALL. ing relative risks in second remission transplants were 0.54 and 0.61. This study confirms earlier findings of an antileukemia effect of GVHD in ALL. This effect was similar in T lineage and B lineage ALL, despite probMaterials and methods able differences in HLA-class II antigen expression. Keywords: ALL; bone marrow transplantation; graftPatients versus-leukemia; T lineage; B lineage Between 1982Between and 1992Between , 1955

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“…Cases of ALI. which were CALLA positive had il more favourble prognosis [13,14J. Studies have shown that the majority of cases of ALL which have been referred to as "non B, non T" ALL are in fact neoplasm of precursor B cells [14,15]. These precursor B-cells show reactivity to CD 19 and sometimes CD 20.…”

Section: Discussionmentioning

confidence: 99%

Immunophenotyping of Acute Leukaemias : A Critical Analysis of 35 Cases

Kumar

Sivadas³

et al. 1995

Medical Journal Armed Forces India

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Accurate classification of acute leukaemias is essential for proper case management. The utility of monoclonal antibodies in the diagnosis and classification of acute leukaemias is well established. This diagnostic utility relates primarily to two poiuts : firstly the distiuction between acute myeloid leukaemia and acute lymphoblastic leukaemia and secondly to subtypes of acute lymphoblastic leukaemia. Leukaemic cells were immunophenotyped using the. alkaline phosphatase antialkaline phosphatase techniques. The monoclonal antibodies were .very useful in distinguishing cases of acute myeloid leukaemia from acute lymphoblastic leukaemia. Cases of acute lymphoblastic leukaemia with CDI0 positivity showed a better prognosis. T-cell acute lymphoblastic leukaemia was uncommon and was associated with unfavourable prognosis. The alkaline phosphatase antialkaline phosphatase technique served as a reliable and convenient method for immunophenotyping of Ieukaemias, MJAFI 1995; 51 : 165-169

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Immunophenotypic Analysis of Acute Leukemia

Cited by 43 publications

References 0 publications

Immunophenotypic Profile in Adult Patients with Acute Leukemia Association with Clinical Feature: Fluorescence Cytometry Quantitative Analysis

Immunophenotypic Profile in Adult Patients with Acute Leukemia Association with Clinical Feature: Fluorescence Cytometry Quantitative Analysis

Graft-versus-leukemia effects in T lineage and B lineage acute lymphoblastic leukemia

Immunophenotyping of Acute Leukaemias : A Critical Analysis of 35 Cases

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