Immunopathology of papillomavirus-induced tumors in different tissues

Jabłońska, Stefania; Orth, Gérard; Lutzner, Marvin A.

doi:10.1007/bf00201955

Cited by 52 publications

(22 citation statements)

References 61 publications

(65 reference statements)

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“…The major problem in EV is a high risk of neoplastic transformation in patients infect ed with EV-specific HPVs (mainly type 5, in rare instances 8 and 14) [28]. Although no primary defect of LCs in generalized HPV infection of EV could be demonstrated in this study, the possible role of these cells in local surveillance at the sites of HPVinduced lesions cannot be excluded.…”

Section: E V Lesionscontrasting

confidence: 40%

Langerhans Cells in Epidermodysplasia verruciformis

Haftek¹,

Jabłońska²,

Szymańczyk³

et al. 1987

Dermatology

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T cell defect and anergy to contact sensitizers are characteristic of the depressed cell-mediated immunity in epidermodysplasia verruciformis (EV). In this disease the generalized infection with human papilloma viruses is associated with a high risk of skin cancers. Langerhans cell density was studied quantitatively in lesions and noninvolved epidermis of EV using OKT6 and anti-HLA-DR monoclonal antibodies with indirect immunofluorescence technique. No significant changes were found in apparently normal skin suggesting no primary defect of Langerhans cells in EV. A marked decrease in Langerhans cell number per unit of epidermal volume could be observed in EV lesions. This additional reduction of immunological surveillance at sites of potentially oncogenic human papilloma virus infection may contribute to the increased risk of malignant transformation in EV lesions.

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Section: E V Lesionscontrasting

confidence: 40%

Langerhans Cells in Epidermodysplasia verruciformis

Haftek¹,

Jabłońska²,

Szymańczyk³

et al. 1987

Dermatology

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“…Another explanation would be a nonspecific booster effect of the regressing warts result ing in immune response to various HPVs. Such a booster injection might be compared to an autogenous vaccination or a specific stimulation of the immune system, which enabled a host to get rid of the viral infection [11,26,30,31].…”

Section: Discussionmentioning

confidence: 99%

“…The importance of cell-mediated immune re sponse in human papilloma virus (HPV) in fections has been reported repeatedly by var ious investigators [2, 3, 11, 13, 15-18, 30, 31 ], but the presented data were often con troversial. Clinical observations suggest a role for nonspecific cell-mediated immunity (CM I) in wart regression [28], The frequency of warts in patients with immune deficiency syndromes and those undergoing immuno suppressive therapy is significantly higher [11,17,27] and the agents known to stimu late CM I have been reported to precipitate the resolution of warts [26,30,31]. Recently, it has been shown that nonspecific CM1 is significantly decreased in some types of HPV infections, especially in those induced by epidermodysplasia verruciformis (EV)-specific HPVs [5 ,8 ,9 ,1 4 .…”

mentioning

confidence: 99%

“…1 5 ,17] and by HPV-3. also inducing plane warts in the general pop ulation [7,8,10,11,14,21,22,24], Resolution of warts is often spontaneous and may be induced by the removal of one of the lesions. Some reports describe the res olution of warts achieved by a specific stim ulation of the patients' immune system with pooled HPV antigens [30,31] and by wart tissue antigens [1], In vitro studies on specific humoral and cell-mediated immunity in patients with warts failed to show uniform results.…”

mentioning

confidence: 99%

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Specific Cell-Mediated Immunity in Patients with Epidermodysplasia verruciformis and Plane Warts

Haftek¹,

Jabłońska

Orth

1985

Dermatology

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The characterization of different types of human papilloma viruses made it possible to study the specific immune responses to purified viral antigens in patients with warts. The specific cell-mediated immunity was investigated by means of a leukocyte migration inhibition factor test in 9 patients with epidermodysplasia verruciformis and 4 patients with regressing plane warts. The results show a significant increase in specific cell-mediated reactivity concomitant with the regression of the warts.

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“…The rare disease of epidermodysplasia verruciformis, in which there is an underlying defect of cellmediated immunity (CMI) (5), is associated with widespread and persistent flat warts and plaque-like lesions which frequently progress to malignancy especially in sun-exposed areas (6). Similarly patients, immunosuppressed therapeutically after renal allograft transplantation, develop multiple persistent warts resistant to treatment, some of which may progress to skin carcinomas (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Lymphoproliferative response to fusion proteins of human papillomaviruses in patients with cervical intraepithelial neoplasia

et al. 1989

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SUMMARYThe cell-mediated immune response (CMI) to E6 and E4 fusion proteins of human papillomavirus type 16 (HPV-16), E6 fusion protein of HPV-18, and to control proteins similarly produced, was analysed in 29 patients with cervical intraepithelial neoplasia (CIN) and in 15 age-matched laboratory personnel using a lymphocyte proliferation assay (LPA).Compared to controls without any added proteins, a positive response (stimulation index > 2-0) to the highly purified E6 control protein was found in only one patient. Positive responses to the E4 control protein which contained ,-galactosidase were noted in three patients and two controls.With control proteins as baseline, the lymphocytes from nine patients (28%) and three laboratory personnel (20%) responded to at least one HPV fusion protein after 7 days in culture. Stimulation indices were low in both groups with a range of 2 06-4-69 and the difference in incidence of positive responses between the groups is not significant. Proliferative responses to HPV-1 and HPV-2 virion antigens were noted in 6/23 (26%) of the patients and 2/15 (18%) of the other group.

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Immunopathology of papillomavirus-induced tumors in different tissues

Cited by 52 publications

References 61 publications

Langerhans Cells in Epidermodysplasia verruciformis

Langerhans Cells in Epidermodysplasia verruciformis

Specific Cell-Mediated Immunity in Patients with Epidermodysplasia verruciformis and Plane Warts

Lymphoproliferative response to fusion proteins of human papillomaviruses in patients with cervical intraepithelial neoplasia

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