Immunopathology of Laboratory Animals

Lebish, Irwin J.; Hurvitz, A. I.; Lewis, Robert M.; Cramer, Donald V.; Krakowka, Steven

doi:10.1177/019262338601400116

Cited by 5 publications

(1 citation statement)

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“…bone marrow derived progenitor cells undergo differentiation/maturation, within the thymic microenvironment, to form the functional T cell repertoire. For an excellent overview of the functional aspects of the immune system one should consult: Abbas (2005), Brown et al (2002), Tizard (2004), and Lebish et al (1986).…”

Section: Normal Functionmentioning

confidence: 99%

Normal Structure, Function and Histology of the Thymus

2006

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The thymus, a primary lymphoid organ and the initial site for development of T cell immunological function, is morphologically similar across species. It is actually an epithelial organ in which its epithelial cells provide a framework containing T cells as well as smaller numbers of other lymphoid cells. A symbiotic interaction exists between the thymic microenvironment and developing T cells, and the specificity of T cell release into the systemic circulation is under thymic control. The thymic cortex in a young animal is heavily populated by developing T cells along with a smaller proportion of associated epithelial cells. Larger, more mature T cells are found in the medulla where epithelial and other cell types are more abundant. Understanding normal morphological features of the thymus and their perturbations provides a cornerstone to assessing immune system function.

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Section: Normal Functionmentioning

confidence: 99%