Immunopathological study on palmar aponeurosis in Dupuytren's disease

Józsa, László; S, Demel; Pintér, T; Renner, A; Réffy, A; Sántha, A; Salamon, A

doi:10.1016/s0065-1281(88)80049-7

Cited by 7 publications

(3 citation statements)

References 5 publications

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“…In terms of the reported immunological component of DD, an autoimmune response to collagen seems a plausible option as explored by Neumuller et al [51]. Also, immune cell infiltrates have been observed in the nodules of DD [34], the early stage of DD development which strongly suggests that an unregulated immune response is, in part, responsible for the initiation of the disease. The identification of the components which act to inhibit the activity of normal wound healing [49] could be of considerable value in the development of novel therapies for fibrotic disorders.…”

Section: Discussionmentioning

confidence: 99%

“…Baird et al [6] observed an increased HLA-DR-activated T-cell infiltrate in DD tissue compared to healthy control tissue. In addition, there are raised levels of IgM and IgA antibodies in DD tissues [34]. Furthermore, Neumuller et al [52] noted a high number of collagen autoantibodies in DD tissue, further advocating an autoimmune mechanism.…”

Section: Immunogenetic Basis Of Ddmentioning

confidence: 99%

“…However, although the disease is well characterized in terms of its histology, the pathogenesis remains uncertain. Yet, there have been several studies which have focused on the genetic and immunological implications of DD [5–9,22,23,29,30,34,37,38,40,52,53], with much interest into the association between certain human leukocyte antigen (HLA) alleles and disease propensity considering the immunoregulatory role of the major histocompatibility complex (MHC) [8,15,25,29,32,55,62,65], (see Table 1).…”

Section: Introductionmentioning

confidence: 99%

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Role of the HLA System in the Pathogenesis of Dupuytren's Disease

McCarty

Syed

Bayat

2010

Hand (New York, N,Y.)

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Dupuytren's disease (DD) is a familial, fibroproliferative, irreversible, and progressive disease of the palmar fascia, yet with unknown etiology. However, there is compelling evidence which has consistently suggested a genetic ethiopathogenesis given the high occurrence among the Northern European extraction, familial nature, and demonstration of concordance in twins. DD is an incurable, recurrent, and potentially debilitating disease with limited and ineffective treatments. Although a number of possible candidate genes have been investigated including matrix metalloproteinases (MMPs) and transforming growth factor-beta (TGF-β) genes, as yet, no consistent genetic biomarker has been identified for DD. The highly polymorphic human leukocyte antigen (HLA) region is an ideal biomarker target. There have been some coherent data within the literature to suggest a genotype to phenotype association between certain HLA loci and a number of fibrotic disorders such as keloid and scleroderma, markedly with class II molecules and disease pervasiveness and clinical progression. The aim of this review, therefore, was to investigate the evidence indicative of both positive and negative associations between particular HLA alleles and DD. There is a clear association with specific HLA alleles and predilection or protection to DD, though there is a pressing need for further supportive data. The most promising of links to the HLA region in terms of a definitive genetic biomarker is with the class II HLA-DR loci. This paper presents a detailed account of the immunogenetic component of DD and explores the possible mechanisms of association between specific HLA molecules and susceptibility to DD.

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Section: Discussionmentioning

confidence: 99%