Immunopathological study of bucillamine-induced nephropathy in patients with rheumatoid arthritis.

Nagakane, Tomoomi; Ogura, Toshio; Nishiya, Koji; Natsumeda, Masamitsu; Haramoto, Toshinori; Sasaki, Toru; Ooyama, Yasuyuki; Makino, Hírofumi; Hirakawa, Syuzo; Suzuki, Shinya; Ota, Zensuke

doi:10.2177/jsci.13.346

Cited by 5 publications

(1 citation statement)

References 2 publications

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“…Bucillamine might be more likely to induce membranous nephropathy than gold thiomalate or D-penicillamine. 26 Most biopsy specimens of membranous nephropathy from bucillamine were early stage (stages I and II) examined by EM in this study, and some did not present clear spikes by PAM staining. 26 Therefore, renal morphological examinations should be performed by IF, EM, and LM.…”

Section: Discussionmentioning

confidence: 61%

Renal involvement in rheumatoid arthritis: analysis of renal biopsy specimens from 100 patients

Makino

Yoshinaga

Yamasaki

et al. 2002

Modern Rheumatology

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We analyzed renal biopsy specimens from 100 patients to evaluate the characteristics of renal involvement in patients with rheumatoid arthritis (RA). Membranous nephropathy (MN) was the most common renal histological pattern (31%). Mesangial proliferative glomerulonephritis (GN) was found in 21% of cases (IgA nephropathy 12%, non-IgA GN 9%), minor changes in 17%, renal amyloidosis in 11%, interstitial nephritis in 9%, sclerotic GN in 4%, and crescentic GN in 2%. MN was relatively more frequent in men than in women, and most developed nephrotic syndrome, while a few developed renal failure. Diseasemodifying antirheumatic drugs (DMARDs) correlated with MN in 26 of 31 cases. Mesangial proliferative GN showed high-grade hematuria. Amyloidosis correlated with long duration of RA; approximately half of the cases with amyloidosis also had nephrotic syndrome, and 82% developed renal failure. Of the 100 patients, 82% showed some tubulointerstitial changes, which might be related to non-steroidal anti-inflammatory drugs. Because renal lesions in RA are very diverse, and early stage cases of MN and amyloidosis can be detected only by histological examinations, renal biopsy should be performed in cases with continuous urinary abnormalities or progressive renal failure.

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Section: Discussionmentioning

confidence: 61%

Renal involvement in rheumatoid arthritis: analysis of renal biopsy specimens from 100 patients

Makino

Yoshinaga

Yamasaki

et al. 2002

Modern Rheumatology

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Significant association between renal function and area of amyloid deposition in kidney biopsy specimens in reactive amyloidosis associated with rheumatoid arthritis

et al. 2011

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The kidney is a major target organ for systemic amyloidosis, resulting in proteinuria and an elevated serum creatinine level. In patients with reactive amyloidosis associated with rheumatoid arthritis, a correlation between the amount of amyloid deposits and clinical parameters is not known. The purpose of this study was to clarify the association between various factors including renal function and the area of amyloid deposition in these patients. Fifty-eight patients with an established diagnosis of reactive AA amyloidosis were studied. We retrospectively investigated the correlation between clinical data and the area occupied by amyloid in renal biopsy specimens. All the patients showed amyloid deposits in renal tissues, and the percentage of the area occupied by amyloid was <10% in 54 of them. Mesangial proliferative glomerulonephritis and membranous nephropathy were frequently combined with renal amyloidosis. For statistical analyses, the percentage of the area occupied by amyloid was transformed to a common logarithmic value (Log(10) % amyloid), as the histograms showed a log-normal distribution. Log(10) % amyloid was found to be correlated with age, creatinine (Cr) level, creatinine clearance (Ccr), blood urea nitrogen (BUN) level, and the estimated glomerular filtration rate (eGFR). Multiple linear regression analyses were then performed to examine the sex- and age-adjusted association between Log(10) % amyloid and each of the clinical variables. Cr, Ccr, BUN, UA, CRP, and eGFR were significantly correlated with Log(10) % amyloid, but urinary protein was not. There was a significant correlation between the area of amyloid deposition in renal tissue and parameters of renal function, especially Cr and Ccr. If amyloid deposition in renal tissue can be arrested or prevented, then it may be possible to maintain renal function at an acceptable level.

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Analysis of 65 Renal Biopsies From Patients With Rheumatoid Arthritis (1976–2015)

Vinicki

Pellet²,

Rosa³

et al. 2015

JCR: Journal of Clinical Rheumatology

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Immunopathological study of bucillamine-induced nephropathy in patients with rheumatoid arthritis.

Cited by 5 publications

References 2 publications

Renal involvement in rheumatoid arthritis: analysis of renal biopsy specimens from 100 patients

Renal involvement in rheumatoid arthritis: analysis of renal biopsy specimens from 100 patients

Significant association between renal function and area of amyloid deposition in kidney biopsy specimens in reactive amyloidosis associated with rheumatoid arthritis

Analysis of 65 Renal Biopsies From Patients With Rheumatoid Arthritis (1976–2015)

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