Immunopathological Patterns of the Stomach in Adenocarcinoma of the Esophagus, Cardia, and Gastric Antrum: Gastric Profiles in Siewert Type I and II Tumors

Mattioli, Sandro; Ruffato, Alberto; Simone, Massimo Pierluigi Di; Corti, Barbara; D’Errico, Antonietta; Lugaresi, Marialuisa; Mattioli, Benedetta; D’Ovidio, Frank

doi:10.1016/j.athoracsur.2007.01.016

Cited by 19 publications

(23 citation statements)

References 32 publications

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“…In contrast, previous studies demonstrated that type I AEG is extremely rare (around 1%‐3%) and that type II & III are predominant in Japan, as was confirmed in our study. This geographical difference might be explained by a correlation of GERD and obesity and an inverse correlation of H. pylori infection with Barrett‐related adenocarcinoma . A certain proportion of type II AEGs as well as the majority of type III AEGs are postulated to develop in association with chronic atrophic gastritis caused by H. pylori, as is the case with GCs .…”

Section: Discussionmentioning

confidence: 99%

“…These include Barrett's esophageal adenocarcinoma which is associated with GERD and obesity, and gastric adenocarcinoma which is most often associated with H. pylori gastritis. According to the Siewert classification, an anatomical subclassification system for AEG, type I AEG (ie epicenter of which locates 1‐5 cm above the esophagogastric junction [EGJ]) represents adenocarcinoma arising from Barrett's esophagus . On the other hand, type III AEG (the epicenter is located 2‐5 cm below the EGJ) mainly includes adenocarcinoma arising from the gastric subcardia and is postulated to undergo the same carcinogenic processes as GC in general .…”

Section: Introductionmentioning

confidence: 99%

“…According to the Siewert classification, an anatomical subclassification system for AEG, 3 type I AEG (ie epicenter of which locates 1-5 cm above the esophagogastric junction [EGJ]) represents adenocarcinoma arising from Barrett's esophagus. 2,[4][5][6] On the other hand, type III AEG (the epicenter is located 2-5 cm below the EGJ) mainly includes adenocarcinoma arising from the gastric subcardia and is postulated to undergo the same carcinogenic processes as GC in general. 7,8 Type II AEG ranges in locations from 1 cm above to 2 cm below the EGJ and almost equally involves the two organs.…”

Section: Introductionmentioning

confidence: 99%

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Adenocarcinoma of the esophagogastric junction and its background mucosal pathology: A comparative analysis according to Siewert classification in a Japanese cohort

et al. 2018

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Adenocarcinoma of the esophagogastric junction (AEG) has heterogeneous carcinogenic process due to its location straddling the esophagogastric junction. We assessed background mucosal pathology and its correlation with clinicopathological features of each Siewert type of AEG. Clinicopathological and immunohistochemical analyses of 103 AEGs and 58 gastric cancers (GCs) were conducted. Background mucosal features were evaluated according to the updated Sydney System. Siewert classification divided 103 AEGs into three type I, 75 type II, and 25 type III tumors, respectively. Two type I, 9 type II AEGs, and none of type III AEGs were Barrett‐related and were excluded from further analysis. Background mucosa of type III AEGs more frequently showed moderate to marked degree of atrophy and intestinal metaplasia than those of type II AEGs and was very similar to those of GCs. Among type II AEGs, tumors with atrophic background were significantly associated with higher patient age and intestinal‐type histology. Type II AEGs with nonatrophic background, but not those with atrophic background, showed more frequent mismatch repair deficiency, TP53 overexpression, and less frequent intestinal phenotypic markers expression than type III AEG or GC. Type II AEGs with atrophic background involved suprapancreatic nodes more frequently than those without. We demonstrated that chronic atrophic gastritis was a major precancerous condition of AEG in the Japanese population, especially Siewert type III which had background mucosal pathology similar to that of GC. Type II AEGs with and without atrophic background showed some clinicopathological differences, and these observations might represent heterogeneous carcinogenic process within type II AEGs.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Adenocarcinoma of the esophagogastric junction and its background mucosal pathology: A comparative analysis according to Siewert classification in a Japanese cohort

et al. 2018

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“…The incidence of adenocarcinoma at antrum or distal stomach has decreased, whereas that at esophagogastric junction (EGJ; the proximal stomach and distal esophagus) has increased in most developed countries [1][2][3][4][5][6]. In 1996, Siewert defined adenocarcinomas located in EGJ as adenocarcinoma of EGJ (AEG).…”

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confidence: 98%

Differences of immunophenotypic markers and signaling molecules between adenocarcinomas of gastric cardia and distal stomach

Xue

Zhang

et al. 2011

Human Pathology

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“…Gastric adenocarcinoma remains the second most common cause of cancer‐related mortality in the world. Recent decades, dramatic changes have been witnessed in both location and lethality of gastric cancers in Western countries . The incidence of distal gastric adenocarcinoma (DGA) has significantly decreased, while adenocarcinomas of the esophagogastric junction (AEGs), including the proximal stomach and distal esophagus, have markedly increased.…”

Section: Introductionmentioning

confidence: 99%

Different roles for p16^INK^4a‐Rb pathway and INK4a/ARF methylation between adenocarcinomas of gastric cardia and distal stomach

Xue

Ouyang

et al. 2014

J of Gastro and Hepatol

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Immunopathological Patterns of the Stomach in Adenocarcinoma of the Esophagus, Cardia, and Gastric Antrum: Gastric Profiles in Siewert Type I and II Tumors

Cited by 19 publications

References 32 publications

Adenocarcinoma of the esophagogastric junction and its background mucosal pathology: A comparative analysis according to Siewert classification in a Japanese cohort

Adenocarcinoma of the esophagogastric junction and its background mucosal pathology: A comparative analysis according to Siewert classification in a Japanese cohort

Differences of immunophenotypic markers and signaling molecules between adenocarcinomas of gastric cardia and distal stomach

Different roles for p16^INK^4a‐Rb pathway and INK4a/ARF methylation between adenocarcinomas of gastric cardia and distal stomach

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Immunopathological Patterns of the Stomach in Adenocarcinoma of the Esophagus, Cardia, and Gastric Antrum: Gastric Profiles in Siewert Type I and II Tumors

Cited by 19 publications

References 32 publications

Adenocarcinoma of the esophagogastric junction and its background mucosal pathology: A comparative analysis according to Siewert classification in a Japanese cohort

Adenocarcinoma of the esophagogastric junction and its background mucosal pathology: A comparative analysis according to Siewert classification in a Japanese cohort

Differences of immunophenotypic markers and signaling molecules between adenocarcinomas of gastric cardia and distal stomach

Different roles for p16INK4a‐Rb pathway and INK4a/ARF methylation between adenocarcinomas of gastric cardia and distal stomach

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Product

Resources

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Different roles for p16^INK^4a‐Rb pathway and INK4a/ARF methylation between adenocarcinomas of gastric cardia and distal stomach