Immunopathological aspects of American Trypanosomiasis: the role of immune complexes in the pathogenesis of the disease

Galvão–Castro, Bernardo; Sá-Ferreira, José Antonio; Pirmez, Claude

doi:10.1590/s0074-02761984000500015

Cited by 7 publications

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“…Similar to other high incidence diseases, basic research in Chagas' disease is characterized by a large number of studies conducted on animal models infected by Trypanosoma cruzi. Different aspects of the human disease are reproduced after infection with Trypanosoma cruzi in mice (Sato et al 1992), hamsters (Santos-Buch & Teixeira 1974), rabbits (Ramirez et al 1994, Rhesus monkeys (Galvão-Castro et al 1984) and dogs (Andrade et al 1984).…”

Section: Research Into Natural Productsmentioning

confidence: 99%

Natural products and Chagas’ disease: the action of triterpenes acids isolated from Miconia species

et al. 2013

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The protozoan Trypanosoma cruzi causes Chagas' disease, a neglected illness that remains a relevant public health concern in Latin America. In Brazil, Benznidazole is available for its treatment. This compound is effective against circulating forms of the parasite in the acute phase of the disease, but its efficacy during the chronic stage is debatable. The search for new medications that can treat Chagas' disease is therefore mandatory. Natural sources display a wide range of secondary metabolites and may play an important role in the discovery of new potential drugs. Miconia is one of the largest genus of the family Melastomataceae and includes approximately 1,000 plant species; Brazil alone is home to approximately 250 of these species, which exist in forests and savannas. Studies on the various biological activities of the Miconia species have reported promising results. Several researchers have screened these plants as well as their extracts in vitro against trypomastigote forms of T. cruzi, which displayed significant trypanocidal activity. It has been demonstrated that the presence of ursolic and oleanolic determines this biological activity.

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Section: Research Into Natural Productsmentioning

confidence: 99%

Natural products and Chagas’ disease: the action of triterpenes acids isolated from Miconia species

et al. 2013

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show abstract

“…Different aspects of the human disease are reproduced after infection with Trypanosoma cruzi in mice (Sato et al 1992), hamsters (Santos-Buch & Teixeira 1974), rabbits (Ramirez et al 1994), Rhesus monkeys (Galvão-Castro et al 1984) and dogs (Andrade et al 1984).…”

Section: Research Into Natural Productsmentioning

confidence: 99%