Immunopathologic Study of the Conjunctiva in Patients with Behçet Disease

Tuğal-Tutkun, İlknur; Urgancioğlu, Meri; Foster, C. Stephen

doi:10.1016/s0161-6420(95)30812-3

Cited by 28 publications

(8 citation statements)

References 26 publications

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“…Indeed, T cells were shown immunohistochemically to be involved in biopsy induced conjunctival inflammation in patients with Behçet's syndrome. 7 In conclusion, conjunctival ulceration should be recognised as an uncommon but possible manifestation of Behçet's syndrome. Therefore, routine examination of the conjunctiva is recommended in patients with Behçet's syndrome, and Behçet's syndrome should be included in a list of differential diagnoses for patients with conjunctival ulcerations.…”

Section: Discussionmentioning

confidence: 94%

The incidence and pathology of conjunctival ulceration in Behcet's syndrome

Matsuo

Itami

Nakagawa

et al. 2002

British Journal of Ophthalmology

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Section: Discussionmentioning

confidence: 94%

The incidence and pathology of conjunctival ulceration in Behcet's syndrome

Matsuo

Itami

Nakagawa

et al. 2002

British Journal of Ophthalmology

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“…The expression of E-selectin and ICAM-1 is more pronounced in the vascular endothelium, suggesting a critical role of these molecules in the initial inflammatory events [5]. It is possible that this increased expression of adhesion molecules is related to an increase in cytokines such as TNF-α, IL-1β and IL-8 produced by monocytes in the attack phase of the disease [6, 7, 8, 9, 10].…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress in Adamantiades-Behçet’s Disease

et al. 1998

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Background: Adamantiades-Behçet’s disease is a chronic systemic disorder associating oral and genital ulcerative lesions with ocular and cutaneous manifestations. Previous publications report increased superoxide production by neutrophils and macrophages, increases in cytokines and malondialdehyde (MDA), as well as low levels of enzymatic antioxidant defenses. Aim: We looked for another marker of oxidative stress in Adamantiades-Behçet’s disease: the presence of clastogenic factors (CF) in patients’ plasma. In addition, we determined plasma endproducts of lipid peroxidation (MDA). Patients and Methods: We studied 20 patients and 20 controls. The clastogenic activity was evaluated by means of cytogenetic methods. This test (CF test) detects circulating prooxidants, due to their clastogenic effects after exposure of lymphocyte cultures of healthy persons to plasma ultrafiltrates from patients. The clastogenic prooxidants are lipid peroxidation products and cytokines, in particular TNF-α. Lipid peroxidation was evaluated by the Yagi method. Results: The CF test was positive in 18 out of 20 patients, while it was negative in all 20 control persons. The mean increase in chromosomal breaks was 10.6 ± 3.8 in cultures exposed to patients’ plasma and 1.3 ± 2.4 for cultures receiving control plasma (p <0.001). The clastogenic effect of patients’ plasma ultrafiltrates was significantly inhibited by superoxide dismutase (EC 1.15.1.1), suggesting an important role of the superoxide radical in the clastogenic pathway. Thiobarbituric-acid-reactive substances (expressed as nanomoles MDA per milliliter) were also significantly increased in these patients: 10.6 ± 3.2 for patients and 6.6 ± 1.4 for controls (p <0.001). Conclusion: The presence of CF in the plasma of patients, indicating the presence of circulating prooxidants with chromosome-damaging effects, confirms an oxidative stress in Adamantiades-Behçet’s disease. The anticlastogenic effect of superoxide dismutase in vitro suggests the implication of the superoxide radical. MDA levels were also significantly increased in patients.

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“…It is most commonly encountered in the Mediterranean countries and Japan (Mishima et al 1979;Yurdakul et al 1988). Ocular involvement is the most frequent serious complication of Behçet's disease (Tugal-Tutkun et al 1996). The rate of incidence of ocular involvement is reported to be 60-90% (Colward et al 1977;Atmaca et al 1996).…”

mentioning

confidence: 99%

Color Doppler ultrasonography in ocular Behçet's disease

Çelebi¹,

Akfirat²,

Çelebi

et al. 2000

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: The aim of this prospective study was to assess the ocular hemodynamic changes in patients with Behçet's disease who had involvement of the posterior segment by color Doppler ultrasonography. Methods: The present study was carried out in 32 eyes of 24 patients with ocular Behçet's disease and 42 eyes of 21 persons as a healthy age-matched control group. In order to detect the hemodynamic changes in ocular Behçet's disease, peak systolic and end-diastolic velocities (PSV, EDV; cm/sec), resistive and pulsatile indices (RI, PI), and PSV/EDV ratio of central retinal artery (CRA), short posterior ciliary artery (PCA) and ophthalmic artery (OA) were determined. Results: The mean PSV and EDV (8.1∫2.6 and 2.7∫0.1 cm/sec, respectively) in the CRA were significantly lower in patients with Behçet's disease than in healthy controls (11.5∫2.2 and 3.5∫1.0 cm/sec, respectively, p∞0.001). For the PCA, these values (12.7∫4.2 and 4.3∫1.1 cm/sec, respectively) were significantly lower in the patient group than in the control the group (18.2∫4.2 and 6.1∫2.5 cm/sec, respectively, p∞0.001). In the patient group, a statistically significant decrease compared to the control group was detected in the mean PSV of the OA (31.8∫8.2 and 35.8∫0.6 cm/sec, respectively, p∞0.02). However, no significant difference in the other parameters of these vessels was observed between groups.Conclusions: These results demonstrate the presence of some circulatory changes in the flow velocities of the CRA, PCA and OA in patients with Behçet's disease when compared with control subjects.

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Immunopathologic Study of the Conjunctiva in Patients with Behçet Disease

Cited by 28 publications

References 26 publications

The incidence and pathology of conjunctival ulceration in Behcet's syndrome

The incidence and pathology of conjunctival ulceration in Behcet's syndrome

Oxidative Stress in Adamantiades-Behçet’s Disease

Color Doppler ultrasonography in ocular Behçet's disease

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