Immunopathologic Manifestations in Patients With Severe Forms of Coxarthrosis

Дмитриева, Людмила Аркадьевна; Коршунова, Е. Ю.; Лебедев, В. Ф.

doi:10.15789/1563-0625-2009-2-3-161-168

Cited by 4 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It's worth noticing that immunoglobulin A levels in the patients with aseptic loosening of their joint implants turned out to be higher than that in the controls. Some authors claim this in combination with other factors may suggest osseous resorption processes [3].…”

Section: Research Resultsmentioning

confidence: 99%

Evaluation of systemic immune response in patients with inflammatory complications of large joint replacements

Mamonova

Babushkina

Ulyanov

et al. 2022

Preprint

View full text Add to dashboard Cite

We studied the features of systemic immunity in patients with inflammatory complications of their knee replacements and used the factor analysis to find immune characteristics associated with the progress of the pathological condition. The components indicative of changes related to the development of cell and humoral immune response in patients were isolated. Our findings present prospects for the development of new diagnostic techniques ensuring higher precision in searching for adequate surgical methods.

show abstract

Section: Research Resultsmentioning

confidence: 99%

Evaluation of systemic immune response in patients with inflammatory complications of large joint replacements

Mamonova

Babushkina

Ulyanov

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Introduction. Impairments of immune system are an important mechanism of the degenerative dystrophic processes in the arthral tissues onset and development [1,2].…”

mentioning

confidence: 99%

The Condition of Cellular Immunity in Patients With Osteoarthrosis Before and After Endoprosthesis Implantation

Белова

Гладкова

Ulyanov

et al. 2019

Medical academic journal

View full text Add to dashboard Cite

Impairments of immune system are an important mechanism of the degenerative dystrophic processes in the arthral tissues onset and development.The objective of this research was to study the cellular immunity condition in patients with osteoarthrosis before and after endoprosthesis implantation. The research methods included immunophenotyping of lymphocytes in the peripheral blood. The immunologic impairments before the surgery referred to change in T-cell immunity reflecting in the imbalance of immunoregulatory subpopulations (decrease of T-suppressor level and increase of T-helper content). At that the number of NK-cells rose which didn’t exclude a possible connection with the cartilage tissue degradation impurities on the background of B-cell number decrease. During the post-surgery period the decrease in T-helper and T-suppressor numbers was detected which may be related to their migration to implantation area due to the decrease of their number in the systemic circulation, at that no significant changes in T-lymphocytes were observed. By contrast, there was a decrease of NK-cell number at higher level of B-cell number showing an adequate response of the bodies for surgery aggression. The results of immunological research are worth being taken into account when preparing patients for endoprosthesis implantation surgery for the purpose of prescribing the immune-correcting drugs for pre-existing impairments of cellular immunity as well as in the post-surgery period to relieve the effects of surgical interference aggravating the impairments in this population of patients.

show abstract