Immunopathologic Findings in Idiopathic Renal Hematuria

Kupor, Lary R.

doi:10.1001/archinte.1975.00330090076008

Cited by 28 publications

(13 citation statements)

References 12 publications

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“…The two patient groups differ slightly in age and sex distribution but are probably sufficiently alike to suggest a real difference in the incidence of the condition. This is supported by a similar study from Kuporet al [16]; they found mesangial deposits of IgA in only 14 of 70 patients who presented with asymptomatic haematuria. Taking into account the universally low oc currence of IgA nephropathy in large American biopsy series [13][14][15] it does appear that there is a lower incidence in that country which cannot be explained by a more selective biopsy policy.…”

Section: Discussionsupporting

confidence: 65%

“…Such studies show a wide variation in the incidence of IgA nephropathy; approximately 11-42% of biopsies per formed for primary glomerular disease in series from France [1,2], Australia [3], Spain [9], Singapore [10], Japan [11] and Italy [12] show IgA nephropathy, while the inci dence has been much lower in studies from North Amer ica [13][14][15][16], the United Kingdom [5], Canada [17] and The Netherlands [8]. For example, Sinniali et al, [10] found IgA nephropathy in 33.7% of 710 renal biopsies in Singa pore, whereas this disease accounted for only 4% of 630 biopsies done in two London hospitals [5].…”

Section: Introductionmentioning

confidence: 99%

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IgA Nephropathy Is Not a Rare Disease in the United Kingdom

Power

Muirhead

Simpson

et al. 1985

Nephron

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A retrospective analysis of all renal biopsies performed in the Grampian Region of Scotland during 1977–1980 revealed that IgA nephropathy was the most frequently encountered glomerular lesion. The commonest indications for renal biopsy were the presence of asymptomatic urinary abnormalities (90/184; 48.9%) especially asymptomatic haematuria (42/184; 22.8%). A histological diagnosis was made in 36 of the 42 patients presenting with asymptomatic haematuria (85.7%); 16 of the 26 cases of IgA nephropathy presented in this way. Overall, IgA nephropathy was detected in 14.1% of all biopsies and accounted for 21.8% of primary glomerular diseases. This study indicates that IgA nephropathy is apparently more common in Grampian than elsewhere in the United Kingdom. However, it is suggested that this does not represent a true variation in the prevalence of the condition; IgA nephropathy is probably a common cause of haematuria in the United Kingdom.

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Section: Discussionsupporting

confidence: 65%

Section: Introductionmentioning

confidence: 99%

IgA Nephropathy Is Not a Rare Disease in the United Kingdom

Power

Muirhead

Simpson

et al. 1985

Nephron

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“…Although microscopic hematuria has been extensively studied in the general population [3][4][5], the indication for performing a renal biopsy, and the type of pathological changes that can be expected in a kidney donor with micro scopic hematuria cannot be ascertained from the literature. Our cases were enrolled into an extensive study to identify the underlying etiologic cause of their microscopic hematu ria.…”

Section: Discussionmentioning

confidence: 99%

“…Reports from the general population showed different types of lesions, Kupor et al [3], examining 80 patients with idiopathic renal hematuria with normal kidney function, reported minimal changes or focal glomerulonephritis in two-thirds of the cases, the remainder exhibiting different proliferative glomerulonephritis, including 9 patients with segmental glomerulosclerosis. Michael et al [5], examining 33 adult patients with microscopic hematuria and normal kidney function, demonstrated 18 patients with IgA ne phropathy, the rest showing either mesangioproliferative lesions without IgA deposits or interstitial nephritis most probably secondary to analgesic abuse.…”

Section: Discussionmentioning

confidence: 99%

Study of Asymptomatic Microscopic Hematuria in Potential Living Related Kidney Donors

Sobh¹,

Moustafa²,

Saleh³

et al. 1993

Nephron

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Thirty potential living related kidney donors with asymptomatic microscopic hematuria of nonsurgical causes were entered in this study. They underwent thorough history taking, medical and ENT examination, laboratory and radiologic assessment and pure-tone audiometry. Family members were also subjected to urine analysis and audiometry. Moreover, the 30 donors were subjected to kidney biopsies which were examined by light microscopy, direct and indirect immunofluorescent microscopy, and electron microscopy. Hereditary nephritis (with or without sensorineural deafness) was found to be the most common cause of asymptomatic microscopic hematuria (25/30), followed by isolated C3 deposits disease (3/30), IgA nephropathy (1/30) and IgM nephropathy (1/30). Since these disease conditions are of a progressive nature, we have concluded that relatives of uremic patients with asymptomatic microscopic hematuria should not be considered for kidney donation even if they are strongly motivated.

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“…It seems probable that the entry of red cells into the glomerular filtrate is post-glomerular, although this point is discussed rarely [2], However, in subjects with IGAN the variability of the concentrations of the plasma globulins and the occurrence of IgA polym ers make it likely that blood rheology may be altered sufficiently to play a causal role in their proteinuria. Proteinuria occurs as a consequence of increased intraglomerular pressure, and the higher the pressure the larger the proteins in urine [3].…”

mentioning

confidence: 99%