Immunopathogenesis of dengue hemorrhagic fever and shock syndrome: Role of TAP and HPA gene polymorphism

The pathogenesis of dengue

“…Data from an Indian cohort showed that HPA-1a and HPA-2b alleles were expressed more frequently in patients with severe disease. 97 In addition the study demonstrated that clinical shock was seen more frequently in HPA-1 heterozygotes. It is possible that cross-reactive antibodies formed in the context of dengue infection may bind to HPA leading to platelet reduction.…”

Genetic Diversity of Dengue Virus and Associated Clinical Severity During Periodic Epidemics in South East Asia

“…et al, (2009) Conducted in Brazil, (also include dengue strains from regions other than South east Asia) but country of origin of these isolates was not clear, Sequences were selected from gene bank. Lanciotti RS.et al, (1994) Conducted in USA, origin of isolates not clear (also include dengue strains from other geographical regions other than South east Asia) The DEN-3 viruses used in this study were obtained from the collection at the Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colo., U.S.A. Soundravally R, et al (2007) Focused on host factors as cause of disease severity rather than on virus gene mutations Focused on host factors as cause of disease severity rather than on virus gene mutations Soundravally R., et al, (2008b) Focused on host factors as cause of disease severity rather than on virus gene mutations Gibbons RV. et al, (2007) Does not give sequence analysis in detail dengue fever, dengue hemorrhagic fever, genetic variation, sequence analysis, south East Asia were used individually as well as in various combinations.…”

The absence of the human platelet antigen polymorphism effect on fibrosis progression in human immunodeficiency virus-1/hepatitis C virus coinfected patients

“…Recently, HPA polymorphism has also been associated with viral infections, including dengue virus infections (17) , HCV monoinfections (18) , and HIV/HCV coinfection (Grotto et al: in press).…”