Immunopathogenesis of Chronic Hepatitis C Virus Infection

Li, Ding You; Schwarz, Kathleen B.

doi:10.1097/00005176-200209000-00005

Cited by 5 publications

(4 citation statements)

References 63 publications

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“…This figure is comparable to our estimate of 27% in a slightly larger cohort ( n = 15) of transfusion acquired HCV. Factors affecting HCV clearance in pediatric infection are poorly understood, but the mode of acquisition, age at acquisition, duration of follow up and comorbidity have been suggested 17 . Our study did not demonstrate a significant difference in HCV clearance by mode of acquisition; however, studies with a larger sample size need to be carried out to clarify this issue.…”

Section: Discussioncontrasting

confidence: 59%

Long‐term outcome of vertically acquired and post‐transfusion hepatitis C infection in children

Rerksuppaphol

Hardikar

Dore

2004

J of Gastro and Hepatol

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Section: Discussioncontrasting

confidence: 59%

Long‐term outcome of vertically acquired and post‐transfusion hepatitis C infection in children

Rerksuppaphol

Hardikar

Dore

2004

J of Gastro and Hepatol

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“…Several excellent reviews discuss the immune response to HCV in great detail [30][31][32][33]. Upon infection with HCV, antigen presenting cells in the liver and the peripheral blood bind to the CD28 receptor on CD4 (+) T helper cells.…”

Section: Pathogenesismentioning

confidence: 99%

Hepatitis C virus in children

Hsu

Murray

2015

J Pediatr Infect Dis

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Chronic hepatitis C viral infection represents a worldwide viral epidemic. The natural course of hepatitis C virus is less understood in the pediatric population, although fewer children progress to cirrhosis and end-stage liver disease than adults infected. In the last five years, epidemiological and clinical research involving hepatitis C virus-infected children has raised interesting observations regarding the differences in transmission, natural history, and response to treatment in this population.

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“…Based on the few studies that have looked at response rates in children, the hypothesis is that children may respond better than adults to pegylated IFN alone or in combination therapy. Avoiding ribavirin in children would be preferable owing to the potential for teratogenicity [23]. Finally, this large trial will be the first to examine the long-term effects of pegylated IFN alfa-2a in children, by examining quality-of-life, cognitive, and growth parameters in children randomized to pegylated IFN alfa-2a with placebo or in combination with ribavirin.…”

Section: Pegylated Interferonmentioning

confidence: 99%