Immunopathogenesis of Autoimmune Hepatitis†

Assis, David N.

doi:10.1002/cld.873

Cited by 20 publications

(14 citation statements)

References 16 publications

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“…Various cytokines have been reported to participate in the pathogenesis of AIH. Th1 cytokine induce macrophage and T-cell activation, Th2 cytokine induce the production of autoantibodies and Th17 cytokines produce pro-inflammatory cytokines, all of which ultimately contribute to hepatocyte necroinflammation [1]. One previous in vivo study demonstrated that RAGE activation was responsible for the Th1 cell activation and cytokine production in pathogenesis of autoimmune response [15].…”

Section: Discussionmentioning

confidence: 99%

“…Autoimmune hepatitis (AIH) is a liver-specific autoimmune disease characterized by hypergammaglobulinemia, increased circulating autoantibodies, transaminases, and histological evidence of interface hepatitis [1]. AIH occurs in all ethnicities and ages, with a female predominance.…”

Section: Introductionmentioning

confidence: 99%

“…Clinically, the serum levels of sRAGE are reduced in several types of auto-immune diseases, such as systemic lupus erythematosus [ 11 ], hashimoto's thyroiditis [ 12 ] and guillain-barré syndrome [ 13 ]. AIH is also an autoimmune disease with hepatocellular injury caused by liver-infiltrated T cells including T helper type 1 (Th1), Th2 and Th17 cells [ 1 , 14 ]. T lymphocyte activation and differentiation was reported to be regulated by RAGE ligation by an in vivo mouse study [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Assessment of EN-RAGE, sRAGE and EN-RAGE/sRAGE as potential biomarkers in patients with autoimmune hepatitis

Liu

Yan

et al. 2020

J Transl Med

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Background Autoimmune hepatitis (AIH) is a liver disease characterized by the autoimmune-induced injury of hepatocytes which can lead to cirrhosis and hepatic failure. The diagnosis and disease management of AIH patients remain challenging due to the diversity of clinical phenotypes and the presence of confounders such as alcohol and viruses. Recently, EN-RAGE and sRAGEs have been implicated in inflammatory-immune response. Nonetheless, their natural behaviour and relationship to disease activity as well as clinical predictive values in AIH development or therapy-induced remission have not been reported. Methods Sixty-seven AIH patients and thirty gender- and age-matched healthy controls (HC) were enrolled. The serum concentrations of EN-RAGE, sRAGE and their ratio (EN-RAGE/sRAGE) in these subjects were measured by ELISA. Besides, the correlations of three parameters with clinical features and therapeutic response were analyzed, respectively. Furthermore, their potential predictive values for monitoring the AIH progression and therapeutic response were also evaluated. Results Higher serum EN-RAGE, lower sRAGE and higher EN-RAGE/sRAGE value were observed in AIH patients. EN-RAGE and sRAGE as well as EN-RAGE/sRAGE were correlated with liver necroinflammation parameters, cirrhosis occurrence and therapeutic response. In addition, we identified that EN-RAGE/sRAGE, EN-RAGE and sRAGE had valuable predicting power for AIH patients, AIH patients with normal ALT and cirrhosis incidence, respectively. More importantly, EN-RAGE/sRAGE also exerted predicting power for the remission in AIH patients. Conclusions AIH patients rendered distinct patterns of serum EN-RAGE, sRAGE or EN-RAGE/sRAGE compared to healthy controls. Moreover, these three parameters exhibited potentials as novel biomarkers for AIH diagnosis and prognosis evaluation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Assessment of EN-RAGE, sRAGE and EN-RAGE/sRAGE as potential biomarkers in patients with autoimmune hepatitis

Liu

Yan

et al. 2020

J Transl Med

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“…In our study, a significant decrease in numerous peripheral cytokine levels (IL-6, IL-8, IL-10, IL17 and IL-23) was detected at the conclusion of the 8-week MBSR course compared to baseline. These reductions are potentially interesting given the association of IL-10, and IL-6 and IL-23/IL-17, with disease pathophysiology in AIH through promotion of pathogenic B-cell and effector T-cell responses, respectively 1,33,34 . A better understanding of the relationship between these peripheral cytokine levels and AIH disease activity in the context of stress reduction through MBSR remains to be determined through future studies.…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Mindfulness-based stress reduction may decrease stress, disease activity, and inflammatory cytokine levels in patients with autoimmune hepatitis

et al. 2022

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“…The pathogenesis of AIH is complex and involves interactions between tolerant liver, environmental triggers, and dysregulated immunological mechanisms. Genetic factors influence an individual’s susceptibility to developing AIH 1 , 2 .…”

Section: Introductionmentioning

confidence: 99%

Pathology of autoimmune hepatitis

et al. 2021

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Summary Autoimmune hepatitis (AIH) is a relatively rare non-resolving chronic liver disease, which mainly affects women. It is characterized by hypergammaglobulinemia, circulating autoantibodies, interface hepatitis on liver histology and a favourable response to immunosuppression. The putative mechanism for the development of autoimmune hepatitis is thought to be the interaction between genetic predisposition, environmental triggers and failure of the native immune system. AIH still remains a major diagnostic and therapeutic challenge, mainly because it is a very heterogeneous disease. Prompt and timely diagnosis is crucial since, if left untreated, AIH has a high mortality rate. Histological demonstration of hepatitis is required for the diagnosis of AIH and, therefore, liver biopsy is mandatory in the initial diagnostic work-up, before treatment. In this review, we summarize the histological features of AIH with the main aim of highlighting the most important clinical-pathological hallmarks useful in the routine diagnostic practice.

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Immunopathogenesis of Autoimmune Hepatitis†

Abstract: http://aasldpubs.onlinelibrary.wiley.com/hub/journal/10.1002/(ISSN)2046-2484/video/15-3-reading-assis a video presentation of this article http://aasldpubs.onlinelibrary.wiley.com/hub/journal/10.1002/(ISSN)2046-2484/video/15-3-interview-assis the interview with the author

Cited by 20 publications

References 16 publications

Assessment of EN-RAGE, sRAGE and EN-RAGE/sRAGE as potential biomarkers in patients with autoimmune hepatitis

Assessment of EN-RAGE, sRAGE and EN-RAGE/sRAGE as potential biomarkers in patients with autoimmune hepatitis

Mindfulness-based stress reduction may decrease stress, disease activity, and inflammatory cytokine levels in patients with autoimmune hepatitis

Pathology of autoimmune hepatitis

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