Immunonutrition in patients with cyctic fibrosis leads to drop of serum amyloid A and increase of oxidative stress

Abstract

The aim of the present study is to evaluate of the impact of immunonutrition on parameters of oxidative stress and inflammation in patients with cystic fibrosis and malnutrition. In the 30 patients with cystic fibrosis and long-term enteral nutrition support for malnutrition the effect of standard and immunonutrion sipping on oxidative stress and inflammatory activity parameters was compared. Malonyldialdehyde (MDA) as parameter of oxidative stress and serum amyloid A (SAA), interleukin 1 and 6, hsCRP, IgM, IgA, IgG as parameters of inflammatory activity were examined. Immunonutrition decreased SAA to 17.6 mg/L comparing to 25.6 mg/L when standard nutrition was given (p = 0.014). MDA was 0.66 µM on standard and 0.96 µM on immunonutrition support (p<0.01). The significant negative correlation was recorded between MDA and SAA, hs-CRP, interleukin 6, IgA and IgG. In conclusion, the application of immunonutrition in patients with cystic fibrosis and malnutrition is associated with drop of SAA but with the rise of MDA.

The Changes of Plasma Amino Acids and Lipid Profiles in Patients with Cystic Fibrosis and Malnutrition induced by Immunonutrition

“…The use of immunonutrition in adult patients with CF and malnutrition leads to the reduction of serum amyloid A (SAA) and may attenuate inflammation activity [3]. The described changes were associated with the modification of the nutritional support.…”

“…Immunonutrition can be defined as modulation of the immune system by specific nutrients like arginine or omega3 fatty acids. Recently we reported the sipping of immunonutrition leads to the reduction of serum amyloid A (SAA) but also to the mild increase of serum malonyldialdehyde (MDA) in the patients with cystic fibrosis and malnutrition [3]. We assume these changes may be the result of modification of protein and lipids metabolism due to immunonutrition composition.…”

Significance of plasma fibrinogen and malondialdehyde in the post-inflammatory period in patients with cystic fibrosis

“…According to the results of our previous study, the administration of immunonutrition to adult patients with cystic fi brosis in the post-infl ammatory period led to a signifi cant decrease in serum amyloid A (SAA) but at the same time to a signifi cant increase in plasma malondialdehyde (4). This result is diffi cult to interpret because in addition to the benefi cial effect on infl ammatory activity, the administration of immunonutrition was associated with an increase in oxidative stress.…”

Plasma Levels of the Bioactive Sphingolipid Metabolite S1P in Adult Cystic Fibrosis Patients: Potential Target for Immunonutrition?

“…Of interest, there is increasing knowledge about the essential role of dietary SL on intestinal inflammatory diseases and colon cancer with reports on anti-inflammatory properties of specific dietary compounds such as milk-Sphingomyelin [20]. Given the intriguing role of immunonutrition for control of oxidative stress in CF patients [21], dietary SL compounds might be of special interest for CF patients, also with regards to nutritional modulation of disease presentation.…”