Immunonutrition (IMN) for prophylaxis of postoperative infections in major surgery

Waitzberg, D.L.; Saito, H.; Planck, L.; Jamieson, G. G.; Schmid, A.; Bihari, D.; Jagannath, P.; Hwang, Tsann‐Long

doi:10.1016/s0261-5614(03)80300-x

Cited by 4 publications

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“…With the onset of phagocytosis of microorganisms by neutrophils, various cellular processes are triggered, including a respiratory burst and the secretion of proteolytic enzymes and immunomodulatory products. As a possible consequence of neutrophils malfunctions, bacterial infections may develop (Waitzberg et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Effect of indole acetic acid administration on the neutrophil functions and oxidative stress from neutrophil, mesenteric lymph node and liver

et al. 2006

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Section: Introductionmentioning

confidence: 99%

Effect of indole acetic acid administration on the neutrophil functions and oxidative stress from neutrophil, mesenteric lymph node and liver

et al. 2006

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Effects of ornithine on neutrophil (PMN) free amino acid and ?-keto acid profiles and immune functions in vitro

Mühling

Fuchs²,

Campos³

et al. 2004

Amino Acids

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The objective of this study was to determine the effects of ornithine on polymorphonuclear leucocyte (PMN) free amino- and alpha-keto acid profiles, superoxide anion (O2-) generation, hydrogen peroxide (H2O2) formation and released myeloperoxidase activity (MPO). Exogenous ornithine significantly increased PMN asparagine, glutamine, aspartate, glutamate, arginine, citrulline, alanine, alpha-ketoglutarate and pyruvate as intracellular ornithine increased. Concerning PMN immune function markers ornithine increased H2O2-generation and MPO activity while O2- -formation was decreased. We believe therefore that ornithine is important for affecting PMN "susceptible free amino- and alpha-keto acid pool" although the mechanisms are not yet clear. This may be one of the determinants in PMN nutrition considerably influencing and modulating PMN host defense capability.

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Benzodiazepine receptor-dependent modulation of neutrophil (PMN) free amino- and ?-keto acid profiles or immune functions

et al. 2004

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We have examined the effects of midazolam, Ro 5-4864 (agonist for "peripheral" [p] benzodiazepine receptors [BR]), PK 11195 (antagonist for pBR), flumazenil (antagonist for "central" BR), naloxone (antagonist for opiate receptors) and the combination of midazolam and Ro 5-4864, PK 11195, flumazenil or naloxone on intracellular amino- and alpha-keto acids and the immune function markers superoxide anion (O(2)(-)), hydrogen peroxide (H(2)O(2)) and released myeloperoxidase (MPO) activity in neutrophils (PMN). Only midazolam and Ro 5-4864 led to significant changes in the dynamic PMN free amino- and alpha-keto acid pools. Concerning PMN immune function markers, midazolam and Ro 5-4864 significantly decreased O(2)(-) and H(2)O(2) formation and released MPO. When midazolam and Ro 5-4864 were applied together they appeared to act additively. Pre-incubation with PK 11195 partially neutralized the midazolam effects whereas flumazenil or naloxone showed no effects. We therefore believe that pBR are involved in the signal transmission of anesthetic-induced cellular metabolic changes in PMN.

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Immunonutrition (IMN) for prophylaxis of postoperative infections in major surgery

Cited by 4 publications

References 0 publications

Effect of indole acetic acid administration on the neutrophil functions and oxidative stress from neutrophil, mesenteric lymph node and liver

Effect of indole acetic acid administration on the neutrophil functions and oxidative stress from neutrophil, mesenteric lymph node and liver

Effects of ornithine on neutrophil (PMN) free amino acid and ?-keto acid profiles and immune functions in vitro

Benzodiazepine receptor-dependent modulation of neutrophil (PMN) free amino- and ?-keto acid profiles or immune functions

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