Immunomorphological condition of placentas in women with repeated pregnancy losses under action of different antigens

Abstract

The aim of the research was to investigate the pathomorphological changes in placentas of women with recurrent pregnancy losses under action of different injuring stimulus (infection, hormonal, biochemical reactions on membrans of syncytiotrophoblast and endothelium of placental vessels, actions of antiphospholipid antibodies). Identical changes was detected which connected with immune complexes (IC) formation. IC with different composition generate immunopathological processes in placental tissues. Present of antiphospholipid antibodies on placental membranes enhancing immunopathological processes, leading to dystrophic and necrotic lesions in surrounding tissues and to placental insufficiency. The outcome of this lesions is incompetent pregnancy.
 Therefore IC may be the marker of placental injury and insufficiency as well as a biologic indicator of failure in reproductive system.
 The treatment of threatened abortion is improve pregnancy outcomes and immunomorphological evidence.