Immunomonitoring of graft‐versus‐host minor histocompatibility antigen correlates with graft‐versus‐host disease and absence of relapse after graft

Laurin, David; Hannani, Dalil; Pernollet, Martine; Moine, Agnès; Plumas, Joël; Bensa, Jean‐Claude; Cahn, Jean‐Yves; Garban, Frédéric

doi:10.1111/j.1537-2995.2009.02440.x

Cited by 10 publications

(5 citation statements)

References 32 publications

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“…The minor histocompatibility antigens, e.g., HA-1, are immunogenic allogeneic antigens responsible for graft-versus-host disease (GVHD) in HLA-matched bone marrow transplantation ( Tseng et al., 1999 , Voogt et al., 1988 ). Laurin et al. (2010) previously showed that minor histocompatibility antigen-associated alloreactivity plays a critical role in the development of GVHD and graft-versus-leukemia (GVL) after HLA-identical hematopoietic stem cell transplantation.…”

Section: Discussionmentioning

confidence: 99%

Successful Transplantation of Retinal Pigment Epithelial Cells from MHC Homozygote iPSCs in MHC-Matched Models

et al. 2016

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SummaryThere is an ongoing controversy as to whether major histocompatibility complex (MHC) matching is a solution for allogeneic stem cell transplantation. In the present study, we established retinal pigment epithelial (RPE) cells from induced pluripotent stem cells (iPSCs) in MHC homozygote donors. We observed no rejection signs in iPSC-derived RPE allografts of MHC-matched animal models without immunosuppression, whereas there were immune attacks around the graft and retinal tissue damage in MHC-mismatched models. In an immunohistochemical examination of MHC-mismatched allografts, the transplanted RPE sheets/cells were located in the subretinal space, but the RPE exhibited inflammatory and hypertrophic changes, and many inflammatory cells, e.g., Iba1+ cells, MHC class II+ cells, and CD3+ T cells, invaded the graft area. Conversely, these inflammatory cells poorly infiltrated the area around the transplanted retina if MHC-matched allografts were used. Thus, cells derived from MHC homozygous donors could be used to treat retinal diseases in histocompatible recipients.

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Section: Discussionmentioning

confidence: 99%

Successful Transplantation of Retinal Pigment Epithelial Cells from MHC Homozygote iPSCs in MHC-Matched Models

et al. 2016

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“…In patients transplanted for management of hematological malignancy treatment failure is often attributable to either the development of life--threatening GVHD or the lack of graft versus malignancy (GVM) effects [11,12]. These are, in turn influenced by the immune reconstitution following transplantation [13,14,15,16]. Hypothetically, repertoire complexity emerging in the reconstituting cell populations may be driven, in part, by the disparity in minor histocompatibility antigens encountered in each instance of SCT [17,18].…”

Section: Introductionmentioning

confidence: 99%

Dynamical System Modeling of Immune Reconstitution after Allogeneic Stem Cell Transplantation Identifies Patients at Risk for Adverse Outcomes

Toor

Sabo

Roberts

et al. 2015

Biology of Blood and Marrow Transplantation

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Systems that evolve over time and follow mathematical laws as they evolve are called dynamical systems. Lymphocyte recovery and clinical outcomes in 41 allograft recipients conditioned using antithymocyte globulin (ATG) and 4.5-Gy total body irradiation were studied to determine if immune reconstitution could be described as a dynamical system. Survival, relapse, and graft-versus-host disease (GVHD) were not significantly different in 2 cohorts of patients receiving different doses of ATG. However, donor-derived CD3+ cell reconstitution was superior in the lower ATG dose cohort, and there were fewer instances of donor lymphocyte infusion (DLI). Lymphoid recovery was plotted in each individual over time and demonstrated 1 of 3 sigmoid growth patterns: Pattern A (n = 15) had rapid growth with high lymphocyte counts, pattern B (n = 14) had slower growth with intermediate recovery, and pattern C (n = 10) had poor lymphocyte reconstitution. There was a significant association between lymphocyte recovery patterns and both the rate of change of donor-derived CD3+ at day 30 after stem cell transplantation (SCT) and clinical outcomes. GVHD was observed more frequently with pattern A, relapse and DLI more so with pattern C, with a consequent survival advantage in patients with patterns A and B. We conclude that evaluating immune reconstitution after SCT as a dynamical system may differentiate patients at risk of adverse outcomes and allow early intervention to modulate that risk.

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“…It has long been postulated that the contingent of cells induced to death includes T-cells associated to the pathology treated. Yet only 5-10% of blood mononuclear cells are exposed to the process (representing less than 1% of the body total T lymphocytes) and only a very small number are the neoplastic T-cell clones or even less in case of GVHD because patients are lymphopenic [4]. Considering the delayed clinical responses observed, mechanisms other than the central role of depleting pathogenic T-cell clones may exist.…”

Section: Mechanisms Of Action For Ecp: From T Lymphocytes Apoptosis Tmentioning

confidence: 97%

Extracorporeal Photopheresis: Scientific and Technical Considerations for Improving Clinical Management of Patients

Garban¹,

Makowski

Carras

et al. 2014

J Stem Cell Res Ther

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Immunomonitoring of graft‐versus‐host minor histocompatibility antigen correlates with graft‐versus‐host disease and absence of relapse after graft

Abstract: Our results provide a robust method to monitor mH antigen graft-versus-host reaction and suggest that current identified mH have predictive value on GVHD and GVL.

Cited by 10 publications

References 32 publications

Successful Transplantation of Retinal Pigment Epithelial Cells from MHC Homozygote iPSCs in MHC-Matched Models

Successful Transplantation of Retinal Pigment Epithelial Cells from MHC Homozygote iPSCs in MHC-Matched Models

Dynamical System Modeling of Immune Reconstitution after Allogeneic Stem Cell Transplantation Identifies Patients at Risk for Adverse Outcomes

Extracorporeal Photopheresis: Scientific and Technical Considerations for Improving Clinical Management of Patients

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