Immunomodulatory properties of Trehala manna decoction and its isolated carbohydrate macromolecules

Hamedi, Azadeh; Farjadian, Shirin; Karami, Mohammad Reza

doi:10.1016/j.jep.2014.12.064

Cited by 25 publications

(21 citation statements)

References 32 publications

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“…To the best of our knowl- Aqueous fraction of oleo-gum-resin is rich in different polysaccharides (8,17,18), such as 4-O-methylglucuronoarabino-galactan (19) 4-O-methylglucuronic acid (20). Polysaccharides from different origins have shown to have cytotoxic/anti-proliferative effects on various cell lines, including vascular smooth muscle cell (21), T-cell leukemia (22) and cervical cancer (23). The findings of this study exhibited the positive role of Frankincense polysaccharides in the aqueous fraction.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Frankincense on Oral Squamous Cell Carcinoma Cell Line

Jaafari‐Ashkavandi¹,

Hamedi²,

Assar³

et al. 2017

Int J Cancer Manag

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Background: Cytotoxic effects of Frankincense resin have been shown on some cancer cell lines. Due to its low side effects, this study was designed to evaluate the anticancer properties of water soluble elements of Frankincense oleo-gum-resin on human oral squamous cell carcinoma cell line. Methods:Oleo-gum-resin was macerated in ethanol. After filtration, the water soluble fraction of dried residue was extracted. KB cells were treated with 0, 62.5, 125, 250 and 500 µg/mL concentrations of obtained Frankincense aqueous fractions and with Doxorubicin as positive control. Frankincense induced cell cytotoxicity; apoptosis and proliferation were investigated using WST assay, Annexin V-FITC/PI, and Ki-67 staining, respectively. Data were analyzed using Kruskal-Wallis test by SPSS 17 software.Results: IC50 of 137.21 µg/mL was obtained from Frankincense aqueous fraction after 48 hours. The percentage of apoptotic cells was elevated in a time-and dose-dependent manner. There was no statistical difference in the Ki-67 expression of KB cells, using different concentration of Frankincense aqueous fraction after 24 and 48 hours (P = 0.083). Doxorubicin inhibited cells growth essentially through apoptosis. Conclusions:Frankincense aqueous fractions seem to suppress KB cell growth through the induction of apoptosis and necrosis rather than the inhibition of proliferation and hence might be a potential anticancer agent. Structural analysis and purification of potent components are suggested for determining more definitive results.

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Section: Discussionmentioning

confidence: 99%

The Effects of Frankincense on Oral Squamous Cell Carcinoma Cell Line

Jaafari‐Ashkavandi¹,

Hamedi²,

Assar³

et al. 2017

Int J Cancer Manag

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“…14,[15][16][17] The leaves were also used for female reproductive problems, 18 improving the liver functions and the whole plant is traditionally used for prevention and treatment of cancers. 19 Recently, published studies proved the presence of several compounds in Bupleurum plant which have relevant physio-biological activities. These ingredients are triterpenoid sapogenin (saikosaponins), 20,21 volatile oils (germacrene D, pinene, heptanal, spathulenol, undecane), 22,23 complex polysaccharides, 24 caffeic acid derivatives, 25 flavonoids, 26 and lignans 14 .…”

Section: Early 19mentioning

confidence: 99%

Phytochemical Analysis, Quantitative Estimations of Total Phenols and Free Radical Scavenging Activity of Bupleurum subovatum from Jerusalem

Jaradat¹,

Eid²,

Abdelwahab³

et al. 2015

Pharm Sci

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“…Different plants, mushrooms and natural products have been used in traditional medicine for treatment of various diseases [1][2][3]. Iridoid and iridoid glycosides have been reported as important metabolites of the Scrophulariaceae family [4].…”

Section: Introductionmentioning

confidence: 99%

“…Neuroprotective activity of diverse iridoids, including 8-O-E-pmethoxycinnamoyl harpagide, 8-O-Z-p-methoxycinnamoyl harpagide, 6'-O-E-p-methoxycinnamoyl harpagide, 6'-O-Z-pmethoxycinnamoyl harpagide, harpagide, E-harpagoside and Zharpagoside have been reported previously [16]. This study was design to investigate neuroprotective potentials of 6-O-methyl,1glucopyranosyl catalpol (1), 6-O-α-L (3"-O-trans, 4"-O-trans cinnamoyl)-rhamnopyranosyl catalpol (2) and scropolioside D (3) (three iridoid glycosides from aerial parts of Scrophularia amplexicaulis) by analyzing their cholinesterase inhibition activity as well as their anti-oxidant properties.…”

Section: Introductionmentioning

confidence: 99%

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In vitro and in silico approach to determine neuroprotective properties of iridoid glycosides from aerial parts of Scrophularia amplexicaulis by investigating their cholinesterase inhibition and anti-oxidant activities

2020

Biointerface Res Appl Chem

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Three iridoid glycosides included 6-O-methyl, 1-glucopyranosyl catalpol (Compound 1), 6-O-α-L (3"-O- trans, 4"-O- trans cinnamoyl)-rhamnopyranosyl catalpol (Compound 2) and scropolioside D (Compound 3) were isolated from aerial parts of S. amplexicaulis using chromatographic methods. The structures were determined by different spectroscopic data. The inhibitory effects (IC50 values) of the compounds on cholinesterase (AChE and BChE) was determined by in-vitro assays. Docking studied were performed to investigate receptor-ligands interactions. The antioxidant capacity was evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, 2, 2'-azino-bis[3-ethylbenzothiazoline]-6-sulphonic acid (ABTS) radical cation, cupric ion reducing activity (CUPRAC), ferric reducing antioxidant power (FRAP), phosphomolybdenum and metal chelating assays. AChE and BChE were moderately inhibited by all of the investigated iridoid glycosides (compared to galantamine). Compound 2 and compound 3 showed comparable anti-oxidant effects with the Trolox as the control in phosphomolybdenum assay. Also, compound 1, showed acceptable activities in ABTS radical scavenging and Phosphomolybdenum assays compared to the control.

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Immunomodulatory properties of Trehala manna decoction and its isolated carbohydrate macromolecules

Cited by 25 publications

References 32 publications

The Effects of Frankincense on Oral Squamous Cell Carcinoma Cell Line

The Effects of Frankincense on Oral Squamous Cell Carcinoma Cell Line

Phytochemical Analysis, Quantitative Estimations of Total Phenols and Free Radical Scavenging Activity of Bupleurum subovatum from Jerusalem

In vitro and in silico approach to determine neuroprotective properties of iridoid glycosides from aerial parts of Scrophularia amplexicaulis by investigating their cholinesterase inhibition and anti-oxidant activities

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