Immunomodulatory properties of stem cells and bioactive molecules for tissue engineering

Molina, Eric R.; Smith, Brandon T.; Shah, Sarita R.; Shin, Heungsoo; Mikos, Antonios G.

doi:10.1016/j.jconrel.2015.08.038

Cited by 40 publications

(21 citation statements)

References 152 publications

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“…MSCs are multipotent cells capable of differentiating into osteocytes, adipocytes, chondrocytes and other cells under defined conditions and can be isolated from various tissues, including bone marrow, adipose, and even peripheral blood [24] , [25] . MSCs exhibit low levels of major histocompatibility complex, therefore they are believed to possess low immunogenicity [26] , [27] . There are no definitive markers for the identification of MSCs, but several surface positive phenotypes such as CD90, CD44, CD73, CD105 and CD146, and negative markers including CD11b, CD34, CD45, CD31 and CD117 are suggested representative markers for MSCs characterisation [28] , [29] .…”

Section: Bottleneck Of Msc-based Therapy For Oamentioning

confidence: 99%

Cartilage repair by mesenchymal stem cells: Clinical trial update and perspectives

Lee

Wang

2017

Journal of Orthopaedic Translation

160

135

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SummaryOsteoarthritis is a degenerative disease of joints with destruction of articular cartilage associated with subchondral bone hypertrophy and inflammation. OA is the leading cause of joint pain resulting in significant worsening of the quality-of-life in the elderly. Numerous efforts have been spent to overcome the inherently poor healing ability of articular cartilage. Mesenchymal stem cells (MSCs) have been in the limelight of cell-based therapies to promote cartilage repair. Despite progressive advancements in MSC manipulation and the introduction of various bioactive scaffolds and growth factors in preclinical studies, current clinical trials are still at early stages with preliminary aims to evaluate safety, feasibility and efficacy. This review summarises recently reported MSC-based clinical trials and discusses new research directions with particular focus on the potential application of MSC-derived extracellular vehicles, miRNAs and advanced gene editing techniques which may shed light on the development of novel treatment strategies.The translational potential of this article: This review summarises recent MSC-related clinical research that focuses on cartilage repair. We also propose a novel possible translational direction for hyaline cartilage formation and a new paradigm making use of extra-cellular signalling and epigenetic regulation in the application of MSCs for cartilage repair.

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Section: Bottleneck Of Msc-based Therapy For Oamentioning

confidence: 99%

Cartilage repair by mesenchymal stem cells: Clinical trial update and perspectives

Lee

Wang

2017

Journal of Orthopaedic Translation

160

135

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“…In addition, MSCs directly or via paracrine action induce fibroblast proliferation, migration, and reduced tissue damage (Liang et al, 2014 ; Li et al, 2015 ). Furthermore, these cells exert anti-immflamatory properties, which include the regulation of the innate and the adaptive immune responses (English, 2013 ; Molina et al, 2015 ; Figure 1B ). Despite the fact that MSCs can modulate molecular and cellular responses directly via cell-cell contact (i.e., cellular differentiation), most studies including ours (Aguilera et al, 2014 ) indicate that their paracrine effects seems to be also important in relation to tissue repair.…”

Section: Mesenchymal Stem Cells (Mscs)mentioning

confidence: 99%

Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Angiogenesis: Potencial Clinical Application

et al. 2016

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Mesenchymal stem cells (MSCs) are adult multipotent stem cells that are able to differentiate into multiple specialized cell types including osteocytes, adipocytes, and chondrocytes. MSCs exert different functions in the body and have recently been predicted to have a major clinical/therapeutic potential. However, the mechanisms of self-renewal and tissue regeneration are not completely understood. It has been shown that the biological effect depends mainly on its paracrine action. Furthermore, it has been reported that the secretion of soluble factors and the release of extracellular vesicles, such as exosomes, could mediate the cellular communication to induce cell-differentiation/self-renewal. This review provides an overview of MSC-derived exosomes in promoting angiogenicity and of the clinical relevance in a therapeutic approach.

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“…Classical tissue engineering approaches generally consist of scaffolds incorporating signals or cells that upon implantation, induce proliferation of the encapsulated cells, alter the phenotype of native cells infiltrating the implant, or promote changes in tissue growth and function. Mesenchymal stem cells are an immunomodulatory cell type that has been particularly important in this area to enhance responses to tissue engineering constructs . These cells have the ability to differentiate into a number of cell lineages, making them attractive in tissue engineering and regenerative medicine approaches aimed at a range of tissue types .…”

Section: Tissue Engineering Constructs Exhibit Intrinsic Immunogenicitymentioning

confidence: 99%

Designing biomaterials with immunomodulatory properties for tissue engineering and regenerative medicine

Andorko

Jewell

2017

Bioengineering & Transla Med

161

123

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Recent research in the vaccine and immunotherapy fields has revealed that biomaterials have the ability to activate immune pathways, even in the absence of other immune‐stimulating signals. Intriguingly, new studies reveal these responses are influenced by the physicochemical properties of the material. Nearly all of this work has been done in the vaccine and immunotherapy fields, but there is tremendous opportunity to apply this same knowledge to tissue engineering and regenerative medicine. This review discusses recent findings that reveal how material properties—size, shape, chemical functionality—impact immune response, and links these changes to emerging opportunities in tissue engineering and regenerative medicine. We begin by discussing what has been learned from studies conducted in the contexts of vaccines and immunotherapies. Next, research is highlighted that elucidates the properties of materials that polarize innate immune cells, including macrophages and dendritic cells, toward either inflammatory or wound healing phenotypes. We also discuss recent studies demonstrating that scaffolds used in tissue engineering applications can influence cells of the adaptive immune system—B and T cell lymphocytes—to promote regenerative tissue microenvironments. Through greater study of the intrinsic immunogenic features of implantable materials and scaffolds, new translational opportunities will arise to better control tissue engineering and regenerative medicine applications.

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Immunomodulatory properties of stem cells and bioactive molecules for tissue engineering

Cited by 40 publications

References 152 publications

Cartilage repair by mesenchymal stem cells: Clinical trial update and perspectives

Cartilage repair by mesenchymal stem cells: Clinical trial update and perspectives

Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Angiogenesis: Potencial Clinical Application

Designing biomaterials with immunomodulatory properties for tissue engineering and regenerative medicine

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