Immunomodulatory properties of new conjugates of muramyl dipeptide and nor-muramyl dipeptide with retro-tuftsin (Arg-Pro-Lys-Thr-OMe)

Wardowska, Anna; Dzierzbicka, Krystyna; Trzonkowski, Piotr; Myśliwski, Andrzej

doi:10.1016/j.intimp.2006.05.004

Cited by 13 publications

(9 citation statements)

References 27 publications

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“…They revealed that MDP and other muramylpeptides of an appropriate size and structure provoked the necrotic reaction, while PGM and other bacterial immunomodulators, which shared many bioactivities with muramypeptides, did not [44]. Numerous MDP variants have been developed to overcome limitations of toxicity, but retaining adjuvant effects [5][6][7][8][9][10][11][12]. Reports mostly agree that all synthesized derivates of MDP could be useful immunoadjuvants.…”

Section: Experimental Groupsmentioning

confidence: 99%

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Comparative study of structurally related peptidoglycan monomer and muramyl dipeptide on humoral IgG immune response to ovalbumin in mouse

Habjanec

Halassy

Tomašić

2010

International Immunopharmacology

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Section: Experimental Groupsmentioning

confidence: 99%

“…A variety of MDP analogs and derivatives have also been synthesized and their adjuvant activities have been examined [5][6][7][8][9][10][11][12]. MDP and its derivates are now known to be PAMPs [13].…”

Section: Introductionmentioning

confidence: 99%

Comparative study of structurally related peptidoglycan monomer and muramyl dipeptide on humoral IgG immune response to ovalbumin in mouse

Habjanec

Halassy

Tomašić

2010

International Immunopharmacology

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“…Herein, we report MDP analogues which contain Fca instead of iGln. Having in mind that activity of previously described MDP analogues depends on their structure and stereochemistry, [13][14][15][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42] we decided to prepare MDP analogues consisting of Lor D-Ala incorporated between muramic acid and Fca. For this purpose, Boc-Fca-OMe (1) was deprotected by action of gaseous HCl in EtOAc and the obtained hydrochloride salt was treated with excess of NEt 3 .…”

mentioning

confidence: 99%

The first ferrocene analogues of muramyldipeptide

Barišić

Roščić

Kovačević

et al. 2011

Carbohydrate Research

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“…Our knowledge about the activity of such conjugates, based on our previous experiments [3][4][5], allowed us to assume that these compounds may induce not only monocytes and macrophages (data in press) but also DCs. Our knowledge about the activity of such conjugates, based on our previous experiments [3][4][5], allowed us to assume that these compounds may induce not only monocytes and macrophages (data in press) but also DCs.…”

Section: Discussionmentioning

confidence: 99%

New Conjugates of Tuftsin and Muramyl Dipeptide as Stimulators of Human Monocyte-Derived Dendritic Cells

Wardowska

Dzierzbicka²,

Menderska³

et al. 2013

Protein and Peptide Letters

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Muramyl dipeptide (MDP) and tuftsin are known biologically active compound displaying a significant influence on various cell populations of innate immune response. MDP, as a fragment of bacterial cell wall, stimulates not only macrophages and monocytes, but also dendritic cells. In contrast, little is known about tuftsin influence on these cells. Therefore it seemed vital to access whether tuftsin or its derivatives conjugated with MDP could influence the activity of this subpopulation of antigen presenting cells (APC). Immature dendritic cells (iDCs) were derived from human monocytes through eight-day tissue culture supplemented with hrIL-4 and hrGM-CSF. On the day 9 DCs were stimulated with newly synthesized conjugates of tuftsin and muramyl dipeptide. The influence of the examined compounds on the activity and maturity of monocyte-derived DCs was estimated by flow cytometry analysis. The flow cytometry analysis revealed that tuftsin and some of its analogues do stimulate maturation and activity of DCs but to a lesser extend in comparison to MDP. The obtained results suggest further development of the experiments concerning the influence of MDP and tuftsin analogues on the activity of dendritic cells.

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Immunomodulatory properties of new conjugates of muramyl dipeptide and nor-muramyl dipeptide with retro-tuftsin (Arg-Pro-Lys-Thr-OMe)

Cited by 13 publications

References 27 publications

Comparative study of structurally related peptidoglycan monomer and muramyl dipeptide on humoral IgG immune response to ovalbumin in mouse

Comparative study of structurally related peptidoglycan monomer and muramyl dipeptide on humoral IgG immune response to ovalbumin in mouse

The first ferrocene analogues of muramyldipeptide

New Conjugates of Tuftsin and Muramyl Dipeptide as Stimulators of Human Monocyte-Derived Dendritic Cells

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