2018
DOI: 10.2174/0929866525666180130141736
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Immunomodulatory Effects of the Water-soluble Lectin from Moringa oleifera Seeds (WSMoL) on Human Peripheral Blood Mononuclear Cells (PBMC)

Abstract: WSMoL promotes immunomodulation in human PBMC inducing a potential wound healing profile and, in future in vivo assays, can be evaluated as adjuvant in immunosuppressive diseases and wound repair.

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Cited by 26 publications
(12 citation statements)
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“…Bioactive compounds identified in the plants include; for V. amygdalina - vernolide (116), vernodalin (117), hydroxyvernolide (120) and vernodalol (123), vernoniosides B1-B3 and vernoniosides A1-A4 (124) ; for N. pobeguinii - strictosamide (138), 19-O-methylangustoline, angustoline (139) , A. Mexicana - berberine (140), tetrahydroberberine, protopine (141), benzophenanthridines, 8-acetonyl dihydrosanguiranine, 8-methoxy dihydrosanguiranine (142) , pancorine (144) , O-methylzanthoxyline (145) , nor-chelerythrine (125) , arnottianamide (146) cryptopine (147) , muramine (148) , argemexicaine A, argemexicaine B (149) ; for A. annua - artemisinin (157) ; C. aurantiifolia - apigenin (156) and Morinda lucida - Morindin (154), oruwal (152), oruwalol (155), oruwacin (150), molucidin (151), Damnacanthal (153), Ursolic acid (17), polypeptides ( Kraft et al, 2003 ; Challand and Willcox, 2009 ; Brahmachari et al, 2013 ; Haidara et al, 2016 ; Haudecoeur et al, 2018 ; Divneet Kaur, 2019 ). Overwhelming evidence supports the standardization of the leaf and seed of M. oleifera for a possible clinical application [ Level III ] as it has demonstrated broad range of antiviral activity in various studies ( Biswas D. et al, 2020 ) while the disulphide-stabilized miniproteins (Morintides), lectins, hevein-like peptides, protein hydrolysates and glucosinolates/isothiocynates isolated from the plant have shown impressive effects, including as antiadhesives, anti-inflammatory, antioxidants and immunomodulatory compounds ( Kini et al, 2017 ; Moura et al, 2017 ; Coriolano et al, 2018 ; Fahey et al, 2019 ; Liang et al, 2019 ; Sousa et al, 2020 ). Aside immunomodulation and free radical scavenging, one mechanism of activity of these lectins and stable polypeptides involve the competitive inhibition of adhesion of pathogen proteins to host polysaccharide receptors [ Level III, V ] ( Sharon, 1986 ; Boas et al, 2019 ).…”
Section: Methodsmentioning
confidence: 99%
“…Bioactive compounds identified in the plants include; for V. amygdalina - vernolide (116), vernodalin (117), hydroxyvernolide (120) and vernodalol (123), vernoniosides B1-B3 and vernoniosides A1-A4 (124) ; for N. pobeguinii - strictosamide (138), 19-O-methylangustoline, angustoline (139) , A. Mexicana - berberine (140), tetrahydroberberine, protopine (141), benzophenanthridines, 8-acetonyl dihydrosanguiranine, 8-methoxy dihydrosanguiranine (142) , pancorine (144) , O-methylzanthoxyline (145) , nor-chelerythrine (125) , arnottianamide (146) cryptopine (147) , muramine (148) , argemexicaine A, argemexicaine B (149) ; for A. annua - artemisinin (157) ; C. aurantiifolia - apigenin (156) and Morinda lucida - Morindin (154), oruwal (152), oruwalol (155), oruwacin (150), molucidin (151), Damnacanthal (153), Ursolic acid (17), polypeptides ( Kraft et al, 2003 ; Challand and Willcox, 2009 ; Brahmachari et al, 2013 ; Haidara et al, 2016 ; Haudecoeur et al, 2018 ; Divneet Kaur, 2019 ). Overwhelming evidence supports the standardization of the leaf and seed of M. oleifera for a possible clinical application [ Level III ] as it has demonstrated broad range of antiviral activity in various studies ( Biswas D. et al, 2020 ) while the disulphide-stabilized miniproteins (Morintides), lectins, hevein-like peptides, protein hydrolysates and glucosinolates/isothiocynates isolated from the plant have shown impressive effects, including as antiadhesives, anti-inflammatory, antioxidants and immunomodulatory compounds ( Kini et al, 2017 ; Moura et al, 2017 ; Coriolano et al, 2018 ; Fahey et al, 2019 ; Liang et al, 2019 ; Sousa et al, 2020 ). Aside immunomodulation and free radical scavenging, one mechanism of activity of these lectins and stable polypeptides involve the competitive inhibition of adhesion of pathogen proteins to host polysaccharide receptors [ Level III, V ] ( Sharon, 1986 ; Boas et al, 2019 ).…”
Section: Methodsmentioning
confidence: 99%
“…Plant lectins can induce the expression of humoral effectors against tumors or microbial infections [136,[141][142][143]. Activated macrophages can produce cytokine signal molecules.…”
Section: Plant Lectins Promote the Release Of Cytokines And Other Effectorsmentioning
confidence: 99%
“…The lectins stimulate cytokine production in different types of immune-related mammalian cells, such as murine macrophages, spleen cells, dendritic cells, mouse spleen cells, and human dendritic cells, neutrophils, peripheral blood mononuclear cells, etc. [136,142,143].…”
Section: Plant Lectins Promote the Release Of Cytokines And Other Effectorsmentioning
confidence: 99%
“…[8][9][10] A WSMoL demonstrou atividade anti-inflamatória in vitro em macrófagos murinos estimulados por lipopolissacarídeos, 11 e foi capaz de ativar linfócitos humanos a partir de culturas de células mononucleares do sangue periférico, mostrando um efeito imunomodulador. 12 Também tem sido comprovado que WSMoL é uma das proteínas coagulantes encontradas nas sementes de M. oleifera, 8,13 e é capaz de reduzir a turbidez e a ecotoxicidade de amostras de água coletadas de um riacho poluído. 14 Está bem demonstrado que muitos antibióticos e algumas classes de drogas anti-inflamatórias estão frequentemente associados a efeitos cardiotóxicos.…”
Section: Introductionunclassified