Immunomodulatory effects of temperature and pH of water in an Indian freshwater sponge

Mukherjee, Soumalya; Bhunia, Anindya Sundar; Bhunia, Niladri Sekhar; Ray, Mitali; Ray, Sajal

doi:10.1016/j.jtherbio.2016.04.005

Cited by 8 publications

(3 citation statements)

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“…The filtrate with suspended cells, was centrifuged (Hermle Z323 K; Hermle Labortechnik, Wehingen, Germany) at 650× g for 10 min, pellets were resuspended in sterile M–medium and stored at 4 °C to minimize cellular aggregation. The viability of sponge cells was routinely examined by staining the cells with 0.4% trypan blue (HiMedia, India) employing the principle of vital dye exclusion (Mukherjee et al , 2016a) and did not exhibit significant alteration.…”

Section: Methodsmentioning

confidence: 99%

Washing soda induced alteration of the differential cell count, nonself surface adhesion efficacy and nuclear morphology of the polyphenotypic cells of a freshwater sponge of India

Mukherjee

Ray

2018

Interdisciplinary Toxicology

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Washing soda has been identified as a precarious contaminant of the freshwater ponds and lakes, the natural habitat of Eunapius carteri. Treatment of sublethal concentrations of washing soda for 384 hours exhibited a significant decrease in the densities of blast like cells, small and large amoebocytes. The percentage occurrence of granular cells and archaeocytes yielded a marked increase against the experimental concentrations of washing soda. Washing soda mediated alterations in the differential cell densities of E. carteri indicative of a state of physiological stress and an undesirable shift in the cellular homeostasis of the organism distributed in polluted environment. Experimental exposure of washing soda yielded a significant increase in the cellular dimensions of large amoebocytes and archaeocytes. Prolonged treatment with washing soda presented a gross reduction in nonself surface adhesion efficacy of E. carteri cells. Experimental concentrations of washing soda resulted in a dose dependent increment in the frequencies of binucleation and micronucleation in the cells of E. carteri. The data were indicative of a high level of genotoxicity of washing soda in E. carteri. The present investigation provides an important information base in understanding the toxin induced chemical stress on the archaic immune defense of a primitive urmetazoa.

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Section: Methodsmentioning

confidence: 99%

Washing soda induced alteration of the differential cell count, nonself surface adhesion efficacy and nuclear morphology of the polyphenotypic cells of a freshwater sponge of India

Mukherjee

Ray

2018

Interdisciplinary Toxicology

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“…67 • Induction of Tolerance or Immune Suppression: EVs can promote immune tolerance or suppress immune responses by delivering immunomodulatory molecules, such as cytokines, chemokines, and regulatory RNAs, to target cells. 68 • Modulation of Inflammatory Responses: EVs can regulate inflammatory responses by promoting the secretion of anti-inflammatory cytokines or inhibiting the production of proinflammatory cytokines and chemokines.…”

Section: Immunomodulationmentioning

confidence: 99%

“…These EV-based vaccines stimulate antigen-specific immune responses, leading to the generation of anti-tumor immunity. 68,72 Additionally, EVs engineered to express immune checkpoint inhibitors, such as programmed cell death ligand 1 (PD-L1) or cytotoxic Tlymphocyte-associated protein 4 (CTLA-4), can block immune checkpoint pathways, enhancing anti-tumor immune responses. Furthermore, EVs play a crucial role in tumor antigen presentation, delivering tumor antigens to APCs like dendritic cells, facilitating antigen presentation to T cells, and activating specific anti-tumor immune responses.…”

Section: Use Of Evs In Cancer Immunotherapymentioning

confidence: 99%

Unlocking The Potential of Extracellular Vesicles for Therapeutic and Diagnostic Application

Yadav,

Kaur

2024

IJPPR

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Extracellular Vesicles (EVs) have emerged as promising candidates for both therapeutic interventions and diagnostic applications due to their unique biological properties and ability to facilitate intercellular communication. This review explores the diverse potential of EVs in the fields of therapeutics and diagnostics. We discuss the biogenesis and composition of EVs, highlighting their cargo of proteins, nucleic acids, and lipids. Furthermore, we delve into the therapeutic applications of EVs, including drug delivery, regenerative medicine, immunomodulation, and cancer therapy. Additionally, we examine the diagnostic utility of EVs, focusing on their role in biomarker discovery and imaging techniques for visualization. Challenges and future directions in EV research, including standardization, clinical translation, and emerging technologies, are also discussed. Overall, this review provides insights into the current understanding of EVs and their potential to revolutionize therapeutic and diagnostic approaches in various disease contexts.1.

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Monocyte/Macrophage: NK Cell Cooperation—Old Tools for New Functions

Wałajtys-Rode

Dzik

2017

Results and Problems in Cell Differentiation

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Monocyte/macrophage and natural killer (NK) cells are partners from a phylogenetic standpoint of innate immune system development and its evolutionary progressive interaction with adaptive immunity. The equally conservative ways of development and differentiation of both invertebrate hemocytes and vertebrate macrophages are reviewed. Evolutionary conserved molecules occurring in macrophage receptors and effectors have been inherited by vertebrates after their common ancestor with invertebrates. Cytolytic functions of mammalian NK cells, which are rooted in immune cells of invertebrates, although certain NK cell receptors (NKRs) are mammalian new events, are characterized. Broad heterogeneity of macrophage and NK cell phenotypes that depends on surrounding microenvironment conditions and expression profiles of specific receptors and activation mechanisms of both cell types are discussed. The particular tissue specificity of macrophages and NK cells, as well as their plasticity and mechanisms of their polarization to different functional subtypes have been underlined. The chapter summarized studies revealing the specific molecular mechanisms and regulation of NK cells and macrophages that enable their highly specific cross-cooperation. Attention is given to the evolving role of human monocyte/macrophage and NK cell interaction in pathogenesis of hypersensitivity reaction-based disorders, including autoimmunity, as well as in cancer surveillance and progression.

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Immunomodulatory effects of temperature and pH of water in an Indian freshwater sponge

Cited by 8 publications

References 61 publications

Washing soda induced alteration of the differential cell count, nonself surface adhesion efficacy and nuclear morphology of the polyphenotypic cells of a freshwater sponge of India

Washing soda induced alteration of the differential cell count, nonself surface adhesion efficacy and nuclear morphology of the polyphenotypic cells of a freshwater sponge of India

Unlocking The Potential of Extracellular Vesicles for Therapeutic and Diagnostic Application

Monocyte/Macrophage: NK Cell Cooperation—Old Tools for New Functions

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