Immunomodulatory effects of protein hydrolysates from rohu (Labeo rohita) egg (roe) in BALB/c mice

Chalamaiah, Meram; Hemalatha, R.; Jyothirmayi, T.; Diwan, Prakash V.; Kumar, Prabhash; Nimgulkar, Chetan; Kumar, B. Dinesh

doi:10.1016/j.foodres.2014.05.050

Cited by 66 publications

(32 citation statements)

References 29 publications

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“…In the last decade, enzymatic hydrolysis of proteins from marine sources has attracted much attention for the production of bioactive peptides, and the biological activities of peptides have been extensively reported in several studies: hypoglycemic and hypolipidemic effects of protein hydrolysates from zebra blenny muscle [3], antioxidant and angiotensin converting enzyme (ACE) inhibitory activities from goby muscle [4], immunomodulatory effects of protein hydrolysates from rohu egg [5], anticoagulant activity [6], etc.…”

Section: Introductionmentioning

confidence: 99%

Characterization, antioxidative and ACE inhibitory properties of hydrolysates obtained from thornback ray ( Raja clavata ) muscle

Lassoued

Mora

Nasri

et al. 2015

Journal of Proteomics

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Section: Introductionmentioning

confidence: 99%

Characterization, antioxidative and ACE inhibitory properties of hydrolysates obtained from thornback ray ( Raja clavata ) muscle

Lassoued

Mora

Nasri

et al. 2015

Journal of Proteomics

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“…() reported that protein hydrolysates derived from salmon pectoral fins showed anti‐inflammatory activity by inhibiting nitric oxide production and proinflammatory cytokines including TNF‐α, IL‐6 and IL‐1β in RAW264.7 macrophage cells. Protein hydrolysates from rohu roe showed immunomodulatory activity by the enhancement of macrophage phagocytosis, level of serum immunoglobulin A (IgA) and natural killer cell activity (Chalamaiah et al ., ). The findings of the present study suggest that seabass skin hydrolysates could suppress the production of proinflammatory cytokines IL‐6 and IL‐1β in macrophage cell lines, thereby protecting the cells from the detrimental effects of an excessive inflammatory response.…”

Section: Resultsmentioning

confidence: 99%

Antioxidant, immunomodulatory and antiproliferative effects of gelatin hydrolysates from seabass (Lates calcarifer) skins

Sae‐leaw

O’Callaghan

Benjakul

et al. 2016

Int J of Food Sci Tech

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Summary This study investigated the antioxidant, immunomodulatory and antiproliferative potentials of gelatin hydrolysates from seabass skins in cell model systems. Gelatin hydrolysates were extracted from seabass skins using different processes and enzyme concentrations. The ability of the hydrolysates to protect against H2O2‐induced DNA damage was assessed on U937 cells using the Comet assay, and one of the samples showed DNA protective effects. All samples showed immunomodulatory potential by significantly (P < 0.05) reducing interleukin‐6 (IL‐6) and IL‐1β production in lipopolysaccharide (LPS)‐stimulated RAW 264.7 macrophage cells. Antiproliferative activities of seabass skin hydrolysates were measured using human colon cancer (Caco‐2) and liver cancer (HepG2) cell lines as the model cell cultures. The inhibition of cell proliferation of Caco‐2 and HepG2 cancer cells occurred in a dose‐dependent manner at concentrations of 1–25 mg mL−1. Therefore, seabass skin hydrolysates prepared using an appropriate process could serve as a potential functional food ingredient with various health benefits.

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“…These results demonstrated that the immunomodulatory effect of the hydrolysates was dependent on the type of protease used to hydrolyze the fish protein. Additionally, the specificity of the enzyme could determine the size and sequence of bioactive peptides …”

Section: Immunomodulatory Peptides Derived From Animal Proteinsmentioning

confidence: 99%

Food‐derived immunomodulatory peptides

et al. 2016

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Food proteins contain specific amino acid sequences within their structures that may positively impact bodily functions and have multiple immunomodulatory effects. The functional properties of these specific sequences, also referred to as bioactive peptides, are revealed only after the degradation of native proteins during digestion processes. Currently, milk proteins have been the most explored source of bioactive peptides, which presents an interesting opportunity for the dairy industry. However, plant- and animal-derived proteins have also been shown to be important sources of bioactive peptides. This review summarizes the in vitro and in vivo evidence of the role of various food proteins as sources of immunomodulatory peptides and discusses the possible pathways involving these properties. © 2016 Society of Chemical Industry.

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Immunomodulatory effects of protein hydrolysates from rohu (Labeo rohita) egg (roe) in BALB/c mice

Cited by 66 publications

References 29 publications

Characterization, antioxidative and ACE inhibitory properties of hydrolysates obtained from thornback ray ( Raja clavata ) muscle

Characterization, antioxidative and ACE inhibitory properties of hydrolysates obtained from thornback ray ( Raja clavata ) muscle

Antioxidant, immunomodulatory and antiproliferative effects of gelatin hydrolysates from seabass (Lates calcarifer) skins

Food‐derived immunomodulatory peptides

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