Immunomodulatory effects of probiotics and prilled fat supplementation on immune genes expression and lymphocyte proliferation of transition stage Karan Fries cows

Punetha, Meeti; Roy, A.; Ajithakumar, H M; Para, Irshad; Gupta, Deepti; Singh, Mahendra; Bharati, Jaya

doi:10.14202/vetworld.2018.209-214

Cited by 8 publications

(3 citation statements)

References 49 publications

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“…In our study, both PA and BHBA induced oxidative stress, increasing mRNA levels of inflammatory factors IL-8, IL-6, and TNF-α. We therefore evaluated levels of IL-8, IL-6, and TNF-α proteins by ELISA, revealing similar trends, which suggested that PA and BHBA promote inflammation, consistent with previous studies [41,42]. NAC, a commonly used antioxidant, exerts anti-oxidative activity and protects cells by scavenging oxygen free radicals under oxidative stress damage [43].…”

Section: Discussionsupporting

confidence: 84%

Palmitic Acid and β-Hydroxybutyrate Induce Inflammatory Responses in Bovine Endometrial Cells by Activating Oxidative Stress-Mediated NF-κB Signaling

Cai

et al. 2019

Molecules

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Ketosis is a nutritional metabolic disease in dairy cows, and researches indicated that ketonic cows always accompany reproductive problems. When ketosis occurs, the levels of non-esterified fatty acids (NEFAs) and β-hydroxybutyrate (BHBA) in the blood increase significantly. Palmitic acid (PA) is a main component of saturated fatty acids composing NEFA. The aim of this study was to investigate whether high levels of PA and BHBA induce inflammatory responses and regulatory mechanisms in bovine endometrial cells (BEND). Using an enzyme-linked immunosorbent assay, quantitative real-time PCR, and western blotting, we evaluated oxidative stress, pro-inflammatory factors, and the nuclear factor (NF)-κB pathway in cultured BEND cells treated with different concentrations of PA, BHBA, pyrrolidinedithiocarbamate (PDTC, an NF-κB pathway inhibitor), and N-acetylcysteine (NAC, an antioxidant). The content of malondialdehyde was significantly higher, the content of glutathione was lower, and antioxidant activity—glutathione peroxidase, superoxide dismutase, catalase, and total antioxidant capacity—was lower in treated cells compared with control cells. PA- and BHBA-induced oxidative stress activated the NF-κB signaling pathway and upregulated the release of pro-inflammatory factors. Moreover, PA- and BHBA-induced activation of NF-κB-mediated inflammatory responses was inhibited by PDTC and NAC. High concentrations of PA and BHBA induce inflammatory responses in BEND cells by activating oxidative stress-mediated NF-κB signaling.

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Section: Discussionsupporting

confidence: 84%

Palmitic Acid and β-Hydroxybutyrate Induce Inflammatory Responses in Bovine Endometrial Cells by Activating Oxidative Stress-Mediated NF-κB Signaling

Cai

et al. 2019

Molecules

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“…Improved nutrient digestion and enhanced cecal microbial population were observed in broilers by adding probiotics [85]. Enhanced immunity was recorded by several studies by the probiotic administration in poultry [86][87][88][89]. In the studies of Zhang et al [90], improved chicken growth rate, immune system, and antioxidant quantity were observed by the addition of Lactobacillus casei, and Bifidobacterium in the food.…”

Section: Probiotics In Poultry Productionmentioning

confidence: 98%

Recent Advances in Probiotic Application in Animal Health and Nutrition: A Review

Bhogoju

Nahashon

2022

Agriculture

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Biotechnological advances in animal health and nutrition continue to play a significant role in the improvement of animal health, growth, and production performance. These biotechnological advancements, especially the use of direct-fed microbials, also termed probiotics, those genetically modified and otherwise, have minimized many challenges facing livestock production around the world. Such advancements result in healthy animals and animal products, such as meat, for a growing population worldwide. Increasing demand for productivity, healthy animals, and consumer food safety concerns, especially those emanating from excessive use of antibiotics or growth promoters, are a driving force for investing in safer alternatives, such as probiotics. The advent of vastly diverse pathogens and bacterial organisms, some of which have acquired antimicrobial resistance due to therapeutic use of these antibiotics, has had a negative impact on the animal and food industries. Probiotics have been chosen as substitutes to counter this excessive use of antibiotics and antibiotic resistance. Over the last decade, probiotics have gained recognition, increased in importance, and stimulated growing interest in the animal health and nutrition industry. Probiotics are considered to be favorable live microorganisms by the host organism by maintaining microbial homeostasis and healthy gut, and can be a viable alternative to antibiotics in addition to providing other growth-promoting properties. Even though various studies describe the modes of action of probiotics, more research is needed to illuminate the exact mechanism of action of probiotics and how they benefit the host. This review describes the importance of probiotics in animal health, nutrition, and in growth and production performance. It also provides a thorough review of recent advances in probiotics research and application in animal health and nutrition and future directions on probiotic research to enhance animal performance.

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“…Probiotics have been proven to enhance immunity in ruminants owing to their immunostimulatory properties (Punetha et al, 2018). The regulation of immune system is by gene expression, stimulation of immune cells action, such as epithelial cells and dendritic cells, natural Killer T cells, and B cells, and controlling the signal process in host cells through the usage of probiotics (Begum et al, 2021).…”

Section: Probiotics and Immunomodulatory Rolementioning

confidence: 99%

Probiotics in Ruminants: A Comprehensive Review of Health, Production and Future Frontiers

K. Devadharshini,

C. Devamugilan

2024

COAS

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The increasing human population is inherently linked to a rising need for both plant and animal-derived food. As a result, scientists look for ways to increase food production efficiency while reducing expenses and maintaining strict quality and safety standards for both human consumption and environmental sustainability. Nevertheless, using antibiotics in animal production comes with a number of challenges. The main concern related to the use of antibiotics is antimicrobial resistance. Probiotics, on the other hand, provide livestock with nutritional and health benefits when given in the right amounts and are becoming a popular, safe, and sustainable substitute for antibiotics. As we explore the potential of individual probiotic strains, we highlight their unique contributions and emphasize how they can help optimize milk production, improve nutrient digestibility, build a robust gut microbiota, and stimulate growth. Probiotics impact the growth parameters, which illustrates their potential as growth promoters. Additionally, their immunomodulatory effects support the natural defence mechanisms of ruminants. This review provides valuable insights into the various applications of probiotics in enhancing the overall well-being and productivity of ruminant livestock. This review highlights the many advantages of probiotics. It presents them as essential components in improving the general health and productivity of ruminant livestock through a thorough literature synthesis.

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Immunomodulatory effects of probiotics and prilled fat supplementation on immune genes expression and lymphocyte proliferation of transition stage Karan Fries cows

Cited by 8 publications

References 49 publications

Palmitic Acid and β-Hydroxybutyrate Induce Inflammatory Responses in Bovine Endometrial Cells by Activating Oxidative Stress-Mediated NF-κB Signaling

Palmitic Acid and β-Hydroxybutyrate Induce Inflammatory Responses in Bovine Endometrial Cells by Activating Oxidative Stress-Mediated NF-κB Signaling

Recent Advances in Probiotic Application in Animal Health and Nutrition: A Review

Probiotics in Ruminants: A Comprehensive Review of Health, Production and Future Frontiers

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