Immunomodulatory effects of Kaempferol on microglial and Macrophage cells during the progression of diabetic retinopathy

Albalawi, Fahad Eid; Alsharif, Ifat; Moawadh, Mamdoh S.; Alkhoshaiban, Abdulaziz; Falah Alshehri, Faez; Albalawi, Aishah E; Althobaiti, Norah A.; Alharbi, Zeyad M.; Almohaimeed, Hailah M.

doi:10.1016/j.intimp.2024.112021

Cited by 2 publications

(2 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The anti-inflammation and anti-oxidation effects of Aiye’s phenolic acids and flavonoids indicated that Aiye may combat the progress of obesity. A variety of bioactive components of Aiye possess anti-oxidation and anti-inflammation effects, including 7-hydroxycoumarin, daphnetin, nepetin, 5,6,4′-trihydroxy-7,3′-dimethoxyflavone, apigenin, kaempferol, hispidulin, jaceosidin, irigenin, and cirsimaritin [ 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 ]. Furthermore, apigenin ameliorates insulin resistance induced by obesity, while cirsimaritin possesses anti-diabetes effects and ameliorates liver disease caused by a high-fat diet [ 49 , 51 , 52 ].…”

Section: Introductionmentioning

confidence: 99%

“…CapillarisinKaempferol 124Anti-oxidation, anti-inflammation, exercise performance improvement, physical fatigue alleviation[41][42][43] Hispidulin120 Anti-inflammation, anti-microbial effects [44-46,99] Capillarisin 114 Anti-asthmatic activity, neuro-protection effects [100,101] Jaceosidin 125 Anti-inflammation and hepatic fibrosis modulation, anti-tumor [19-21,47] Centaureidin 118 Immunomodulatory effects, vasorelaxant activity [102,103] Irigenin 107 Lung injury amelioration, anti-inflammation, anti-cancer effects [48,104] Irigenin 107 Lung injury amelioration, anti-inflammation, anti-cancer effects [48,104]107 Lung injury amelioration, anti-inflammation, anti-cancer effects [48,104] Cirsimaritin Life 2024, 14, x FOR PEER REVIEW 12 of 26 Cirsimaritin 115 Colitis alleviation, anti-diabetic activities, antiinflammation, anti-oxidation, and hepatoprotection effects [49-51] Eupatilin 120 Anti-tumor effects, anti-osteoporosis, gastrointestinal hemorrhage prevention, hyperuricemia attenuation, nephroprotection [26,105-107] 3.6. Construction of PPI Network 115 Colitis alleviation, anti-diabetic activities, anti-inflammation, anti-oxidation, and hepatoprotection effects [49-51] Eupatilin Life 2024, 14, x FOR PEER REVIEW 12 of 26 Cirsimaritin 115 Colitis alleviation, anti-diabetic activities, antiinflammation, anti-oxidation, and hepatoprotection effects [49-51] Eupatilin 120Anti-tumor effects, anti-osteoporosis, gastrointestinal hemorrhage prevention, hyperuricemia attenuation, nephroprotection[26,[105][106][107] …”

mentioning

confidence: 99%

See 1 more Smart Citation

Elucidation of Anti-Obesity Mechanisms of Phenolics in Artemisiae argyi Folium (Aiye) by Integrating LC-MS, Network Pharmacology, and Molecular Docking

Liu,

Luo,

2024

Life

View full text Add to dashboard Cite

The global prevalence of obesity is a pressing health issue, increasing the medical burden and posing significant health risks to humans. The side effects and complications associated with conventional medication and surgery have spurred the search for anti-obesity drugs from plant resources. Previous studies have suggested that Artemisiae argyi Folium (Aiye) water extracts could inhibit pancreatic lipase activities, control body weight increase, and improve the plasma lipids profile. However, the exact components and mechanisms were not precisely understood. Therefore, this research aims to identify the chemical profile of Aiye and provide a comprehensive prediction of its anti-obesity mechanisms. The water extract of Aiye was subjected to LC-MS analysis, which identified 30 phenolics. The anti-obesity mechanisms of these phenolics were then predicted, employing network pharmacology and molecular docking. Among the 30 phenolics, 21 passed the drug-likeness screening and exhibited 486 anti-obesity targets. The enrichment analysis revealed that these phenolics may combat obesity through PI3K-Akt signaling and MAPK, prolactin, and cAMP signaling pathways. Eight phenolics and seven central targets were selected for molecular docking, and 45 out of 56 docking had a binding affinity of less than −5 kcal/mol. This research has indicated the potential therapy targets and signaling pathways of Aiye in combating obesity.

show abstract

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Elucidation of Anti-Obesity Mechanisms of Phenolics in Artemisiae argyi Folium (Aiye) by Integrating LC-MS, Network Pharmacology, and Molecular Docking

Liu,

Luo,

2024

Life

View full text Add to dashboard Cite

show abstract

Bibliometric and visual analysis of global publications on kaempferol

Tang,

Lin,

Liu

et al. 2024

Front. Nutr.

View full text Add to dashboard Cite

IntroductionKaempferol, a flavonoid found in numerous foods and medicinal plants, offers a range of health benefits such as anti-inflammatory, antioxidant, antiviral, anticancer, cardioprotective, and neuroprotective effects.MethodsHerein, a bibliometric and visual analysis of global publications on kaempferol was performed to map the evolution of frontiers and hotspots in the field. Using the search string TS = kaempferol, bibliometric data for this analysis was extracted from the Web of Science Core Collection database and analyzed using the VOSviewer, CiteSpace, and Scimago Graphica software.ResultsAs a result, by February 26, 2024, 11,214 publications were identified, comprising articles (n = 10,746, 96%) and review articles (n = 468, 4%). Globally, the annual number of kaempferol publications surpassed 100 per year since 2000, exceeded 500 per year since 2018, and further crossed the threshold of 1,000 per year starting in 2022. The major contributing countries were China, the United States of America, and India, while the top three institutes of the citations of kaempferol were the Chinese Academy of Sciences, Consejo Superio de Investigaciones Cientficas, and Uniersidade do Porto. These publications were mainly published in agricultural and food chemistry journals, food chemistry, and phytochemistry.DiscussionThe keywords frequently mentioned include phenolic compounds, antioxidant activity, flavonoids, NF-kappa B, inflammation, bioactive compounds, etc. Anti-inflammation, anti-oxidation, and anti-cancer have consistently been the focus of kaempferol research, while cardiovascular protection, neuroprotection, antiviral, and anti-bacterial effects have emerged as recent highlights. The field of kaempferol research is thriving.

show abstract

Immunomodulatory effects of Kaempferol on microglial and Macrophage cells during the progression of diabetic retinopathy

Cited by 2 publications

References 56 publications

Elucidation of Anti-Obesity Mechanisms of Phenolics in Artemisiae argyi Folium (Aiye) by Integrating LC-MS, Network Pharmacology, and Molecular Docking

Elucidation of Anti-Obesity Mechanisms of Phenolics in Artemisiae argyi Folium (Aiye) by Integrating LC-MS, Network Pharmacology, and Molecular Docking

Bibliometric and visual analysis of global publications on kaempferol

Contact Info

Product

Resources

About