Immunomodulatory Effects of Jacalin, a Dietary Plant Lectin on the Peripheral Blood Mononuclear Cells (PBMCs)

Lavanya, V.; Bommanabonia, Anil Kumar; Ahmed, Noman; Jamal, Shazia

doi:10.1007/s12010-021-03722-6

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…(Subramaniyan et al 2021) studied Jacalin-derived silver nanoparticles which had good antibacterial activity and it was found to have killed Staphylococcus aureus in less than 30 min, by inducing oxidative stress and membrane damage. (Lavanya et al 2022) researched the effect of jacalin on the proliferation and cytokine production of peripheral blood mononuclear cells (PBMCs) and found that it had hindered tumor growth for a stipulated time point. Another lectin namely, Artocarpin derived from Jackfruit (Artocarpus heterophyllus Lam.)…”

Section: Lectinsmentioning

confidence: 99%

Finding out various potentials and possibilities of jackfruit seed and its usage in the industry: a review

Brahma

Ray

2023

Food Prod Process and Nutr

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Despite the fact that jackfruit seeds have been demonstrated to contain a variety of beneficial nutrients or bioactive components that add real value to meals, they remain underutilized due to limited commercial jackfruit production. They include a wide variety of nutrient-dense components, including as starch, fibre, phytonutrients, protein, minerals, lectins, as well as beneficial components like phenols and flavonoids. This review focuses on the significant findings regarding starch extraction techniques and different conventional and novel modification techniques and their influence on functional properties of jackfruit seed. Jackfruit seeds are primarily rich in seed starch (70–85%), which is used in food processing and other areas as thickeners, stabilizer, microencapsulating agent, coagulants, bioplastics etc. and provide significant health benefits. Applicability of jackfruit seed starch is also well established. There is a significant impact on jackfruit seed processing using different techniques in order to achieve versatile nutritional and functional components. The creation of composite films, starch, food items, bioethanol, pigments, and medical applications are the key areas of ongoing study. This paper was developed by analysing more than 150 scientific publications including recent studies of various researchers, with a primary focus on the features of jackfruit seeds. Graphical Abstract

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Section: Lectinsmentioning

confidence: 99%

Finding out various potentials and possibilities of jackfruit seed and its usage in the industry: a review

Brahma

Ray

2023

Food Prod Process and Nutr

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“…Jacalin also boosted the mRNA expression of the pro-inflammatory cytokine interferon at first, but after extended stimulation of PBMCs, the expression of the anti-inflammatory cytokines, primarily transforming growth factor (TGF), increased. Resulting in it showing an immunomodulatory effect [30].…”

Section: Jacalin-related Lectin As Glycol-biomarkers and Cancer Therapymentioning

confidence: 99%

Jackfruit waste: an invented anticancer therapy using Jacalin lectin from jackfruit seed

Ghosh,

K.M.,

Pandey

et al. 2023

Anti-Cancer Drugs

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Every food source contains both edible and inedible waste components. Millions of tonnes of trash from the food business are made from fruits, and these wastes are containing higher-value medicinal components, such as alkaloids, flavonoids, phenolic contents, a huge amount of proteins and secondary metabolites. These bioactive phytoconstituents are being used for the treatment of many serious fatal diseases. So, utilizing the recovered bioactive molecules from food wastes as functional ingredients offers a long-term alternative source of therapeutically active components that will lead to the discovery of novel phytoconstituents or novel treatment approaches. The goal of this systematic study is to provide an overview of the jackfruit (Artocarpus heterophyllus Lam, Moraceae) edible byproducts, such as jackfruit seeds that are largely neglected. This seed contains numerous bioactive lead molecules, such as carbohydrate-binding protein jacalin, which exhibits potent anticancer activity against colon cancer, blood cancer and breast cancer as well as can enlighten the new possible treatment approaches in targeted therapy and photodynamic chemotherapy. Moreover, jackfruit waste seed can be taken as a dietary food, which is having property to prevent and treat cancer and other lifestyle diseases. The works that have been carried out to utilize jackfruit waste other than the juicy edible bulbs have been reviewed in this article.

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Immunomodulatory effects and mechanisms of the extracts and secondary compounds of Zingiber and Alpinia species: a review

et al. 2023

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Zingiber and Alpinia species (family: Zingiberaceae) are popularly used in food as spices and flavoring agents and in ethnomedicine to heal numerous diseases, including immune-related disorders. However, their ethnomedicinal uses have not been sufficiently supported by scientific investigations. Numerous studies on the modulating effects of plants and their bioactive compounds on the different steps of the immune system have been documented. This review aimed to highlight up-to-date research findings and critically analyze the modulatory effects and mechanisms of the extracts and secondary compounds of several Zingiber and Alpinia species, namely, Zingiber officinale Roscoe, Z. cassumunar Roxb., Z. zerumbet (L.) Roscoe ex Sm., Alpinia galanga Linn., A. conchigera Griff, A. katsumadai Hayata, A. oxyphylla Miq., A. officinarum Hance, A. zerumbet (Pers.) Burtt. et Smith, and A. purpurata (Viell.) K. Schum. on the immune system, particularly via the inflammation-related signaling pathways. The immunomodulating activities of the crude extracts of the plants have been reported, but the constituents contributing to the activities have mostly not been identified. Among the extracts, Z. officinale extracts were the most investigated for their in vitro, in vivo, and clinical effects on the immune system. Among the bioactive metabolites, 6-, 8-, and 10-gingerols, 6-shogaol, and zerumbone from Zingiber species and cardamomin, 1′-acetoxychavicol acetate, yakuchinone, rutin, 1,8-cineole, and lectin from Alpinia species have demonstrated strong immunomodulating effects. More experimental studies using cell and animal models of immune-related disorders are necessary to further understand the underlying mechanisms, together with elaborate preclinical pharmacokinetics, pharmacodynamics, bioavailability, and toxicity studies. Many of these extracts and secondary metabolites are potential candidates for clinical development in immunomodulating agents or functional foods to prevent and treat chronic inflammatory disorders.

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Immunomodulatory Effects of Jacalin, a Dietary Plant Lectin on the Peripheral Blood Mononuclear Cells (PBMCs)

Cited by 3 publications

References 37 publications

Finding out various potentials and possibilities of jackfruit seed and its usage in the industry: a review

Finding out various potentials and possibilities of jackfruit seed and its usage in the industry: a review

Jackfruit waste: an invented anticancer therapy using Jacalin lectin from jackfruit seed

Immunomodulatory effects and mechanisms of the extracts and secondary compounds of Zingiber and Alpinia species: a review

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