Immunomodulatory Effects of Curcumin

Abstract

Curcumin (diferuloylmethane), found in the spice turmeric, exhibits anti-inflammatory, antioxidant, and chemopreventive activities. However, the effect of curcumin on the immunological responses largely remains unknown. In this study we have investigated the effect of curcumin on mitogen (phytohaemagglutinin; PHA) stimulated T-cell proliferation, natural killer (NK) cell cytotoxicity, production of cytokines by human peripheral blood mononuclear cells (PBMCs), nitric oxide (NO) production in mouse macrophage cells, RAW-264.7. Furthermore, we have carried out an electromobility shift assay to elucidate the mechanism of action of curcumin at DNA protein interaction level. We observed that curcumin inhibits PHA-induced T-cell proliferation, interleukin-2 production, NO generation, and lipopolysachharide-induced nuclear factor-kappaB (NF-kappaB) and augments NK cell cytotoxicity. Our results suggest that curcumin most likely inhibits cell proliferation and cytokine production by inhibiting NF-kappaB target genes involved in the induction of these immune parameters.

Evaluation of Efficacy of 1% Curcuminoids as Local Application in Management of Oral Lichen Planus – Interventional Study

“…This effect of OLP would be beneficial as the pathogenesis of OLP is by T-lymphocyte mediated cytotoxicity and any immunomodulatory effect would be beneficial in reducing the severity of the disease [25].…”

A comparative study on the antioxidant and immunomodulatory properties of curcumin conjugated gold nanospheres and free curcumin

“…Several studies on the antimicrobial and . Email: senguptamahuya35 @ gmail.com immunomodulatory activities of curcumin have been reported (Yadav et al, 2005;Moghadamtousi et al, 2014). An increasing number of studies show that polyphenolic nutritional are capable of blocking neuronal death in vitro and many therapeutic properties in animal models of neurodegenerative diseases including Alzheimer's (Hishikawa et al, 2012) and Parkinson's disease (Zbarsky et al, 2005;Mythri and Bharath, 2012).…”

Hepatoprotective and immunomodulatory properties of aqueous extract of Curcuma longa in carbon tetra chloride intoxicated Swiss albino mice

“…The curcumin can suppress the PHA-induced proliferation of human peripheral blood mononuclear cells (PBMCs) and inhibit IL-2 expression and NF-AB [13]. In another report, curcumin inhibited the activation of human V B CT cells induced cancer by phosphoantigens [14] .…”