Immunomodulatory effects of a traditional Chinese medicine, Chi-Shie-Shuang-Bu-An-Shen-Tang, on BALB/c mice

Experimental immunology Influence of polysaccharide fraction C isolated from Caltha palustris L. on T and B lymphocyte subsets in mice

“…In the present study, the increase of the CD4 + lymphocyte population (thymus, spleen) after administrating fraction C from Caltha palustris extract was reported. This effect was similar to the results reported by Wu et al [16], who investigated the traditional Chinese medicine, Chi-ShieShuang-Bu-An-Shen-Tang (CST). The oral administration of sterilized CST for 3 weeks caused an increase in the population of CD4 + T cells in spleen.…”

Experimental immunology Modulation of murine T and B lymphocyte subsets by polysaccharide fraction B isolated from Caltha palustris L.

“…The CD8 + cells recognize antigens presented by MHC I molecules and mediate cellular immune responses through cytotoxic T cells. Wu et al [19], who investigated the traditional Chinese medicine, Chi-Shie-Shuang-Bu-An-Shen-Tang (CST), reported the significant increase in the population of CD4+ T cells in spleen after oral administration of sterilized CST for 3 weeks. The authors suggest that probably the polysaccharide component was responsible for this activity.…”

Therapeutic effect of a Chinese herbal compound on spontaneous lupus MRL/lpr mice

“…The deficiency is treated by nourishing yin to reduce fire, and the excess is treated by activating blood and clearing heat and toxins (Yang and Xu, 2005). According to English literature, several studies focusing on reinforcing deficiency have been reported, such as Liu-Wei or Ba-Wei-Di-Huang-Wan (Chen et al, 2011;Furuya et al, 2002), Ren-Shen-Yang-Rong-Tang (Kawakita et al, 1998;Nakai et al, 1993;Zhou et al, 1994), and Chi-Shie-Shuang-Bu-An-Shen-Tang (Wu et al, 2007). The herbs used in these formulations, called the "superior herbs" in Chinese medicine, are used to reinforce deficiency, fortify the body and mind, and also enhance adaptability to stress.…”