Immunomodulatory effects of a bioactive fraction of Strobilanthes crispus in NMU-induced rat mammary tumor model

Yankuzo, Hassan Muhammad; Baraya, Yusha'u Shu'aibu; Zulkarnain, Muhammad; Wong, Kah Keng; Yaacob, Nik Soriani

doi:10.1016/j.jep.2017.10.024

Cited by 18 publications

(11 citation statements)

References 38 publications

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“…However, the most potent extract was the crude and DCM extract of SD. Though compounds from DCM extracts generally lack antioxidant properties, they are rich in cytotoxic, anti-apoptotic properties [36]. In the present study, rotenone caused a significant increase in the level of malonedialdehyde (MDA).…”

Section: Mitochondria Respiratory Enzymes (Mre)mentioning

confidence: 59%

Reversal effect of Solanum dasyphyllum against rotenone-induced neurotoxicity

Ilesanmi

Obade

Odewale

et al. 2020

Current Issues in Pharmacy and Medical Sciences

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We earlier reported the protective effect of Solanum dasyphyllum against cyanide neurotoxicity. In furtherance to this, we investigated the protective effect of S. dasyphyllum against rotenone, a chemical toxin that causes brain-related diseases. Mitochondria fraction obtained from the brain of male Wistar rats was incubated with various solvents (hexane, dichloromethane, ethylacetate, and methanol) extracts of S. dasyphyllum before rotenone exposure. Mitochondria respiratory enzymes (MRE) were evaluated along with markers of oxidative stress. The inhibition of MRE by rotenone was reversed by treatment with various fractions of S. dasyphyllum. The oxidative stress induced by rotenone was also reversed by fractions of S. dasyphyllum. In addition, the ethylacetate fraction of S. dasyphyllum was most potent against rotenone-induced neurotoxicity. In conclusion, S. dasyphyllum is rich in active phytochemicals that can prevent some neurotoxic effects of rotenone exposure. Further study can be done in an in vivo model to substantiate our results.

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Section: Mitochondria Respiratory Enzymes (Mre)mentioning

confidence: 59%

Reversal effect of Solanum dasyphyllum against rotenone-induced neurotoxicity

Ilesanmi

Obade

Odewale

et al. 2020

Current Issues in Pharmacy and Medical Sciences

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“…Immunomodulatory effects of the dichloromethane fraction (F3) of S. crispus were evaluated by Yankuzo et al In terms of cellular immune parameters, the results showed that administration of F3 significantly increased (p < 0.05) the number of infiltrating CD4+ and CD8+ immune cells as well as the expression of CIITA and MHC-II on the mammary cancer cells compared to the untreated group. In addition to that, the serum level of chemokine ligand 2 (CCL2) was found to be significantly decreased (p < 0.05) after eight weeks of treatment, while the level of interferon gamma (IFN-γ) was increased the most among the 34 cytokines examined, although it was not significant (p = 0.083) [67]. The author suggested that a rise in the number of IFN-γ activated more CD4+ and CD8+ immune cells, accompanied by upregulation of CIITA expression which in turn promoted the expression of MHC-II molecules that are responsible for the binding of CD4+ T cells, could lead to the destruction of the mammary tumor [68][69][70][71][72].…”

Section: In Vivo Studiesmentioning

confidence: 97%

Anticancer Properties of Strobilanthes crispus: A Review

et al. 2021

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Cancer is a major cause of death worldwide, as exemplified by millions of cancer diagnoses every year. The use of chemotherapy in treating cancer has many disadvantages which include recurrence of cancer, associated with drug resistance, and severe side effects that are harmful to the patients. A better source of anticancer drugs can come from nature. Strobilanthes crispus (S. crispus) is a herbal medicinal plant that is indigenous in Madagascar and the Malay Archipelago. The plant possesses high vitamin and mineral content as well as phytochemicals—like phenols, catechins, tannins, and flavonoids—that are known to have therapeutic effects. Numerous preclinical studies have reported very versatile pharmacological effects of this plant, such as anticancer, antimicrobial, antioxidant, anti-angiogenesis, anti-diabetes, anti-ulcerogenic, and wound healing. Herein, this paper reviews the anticancer properties of S. crispus, providing information for future research and further exploration.

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“…It encompasses a diverse population of abnormal cells that are genetically modified to overcome cell proliferation barriers and able to metastasize other body tissues (Harbeck et al, 2019). Among varied cancer types, breast cancer is the most prevailing neoplastic disease and the leading cause of death among women worldwide (Yankuzo et al, 2018). This malignancy is responsible for more than 1.5 million diagnoses and five hundred thousand deaths annually worldwide, the incidence of which is expected to reach up to 3.2 million cases per year by 2050 (Abolghasemi et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Triazine Derivative as Putative Candidate for the Reduction of Hormone-Positive Breast Tumor: In Silico, Pharmacological, and Toxicological Approach

et al. 2021

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Background and objectives: Breast cancer is a heterogeneous disease that poses the highest incidence of morbidity among women and presents many treatment challenges. In search of novel breast cancer therapies, several triazine derivatives have been developed for their potential chemotherapeutic activity. This study aims to evaluate the N-nitroso-N-methyl urea (NMU)–induced anti–mammary gland tumor activity of 2,4,6 (O-nitrophenyl amino) 1,3,5-triazine (O-NPAT).Methods: The in silico modeling and in vitro cytotoxicity assay were performed to strengthen the research hypothesis. For in vivo experimentation, 30 female rats were divided into five groups. Group I (normal control) received normal saline. Group II (disease control) received NMU (50 mg/kg). Group III (standard control) was treated with tamoxifen (5 mg/kg). Groups IV and V received O-NPAT at a dose level of 30 and 60 mg/kg, respectively. For tumor induction, 3 intraperitoneal doses of NMU were given at a 3-week interval, whereas all treatment compounds were administered orally for 14 consecutive days. Biochemical and oxidative stress markers were estimated for all experimental animals. DNA strand breakage alongside inflammatory markers was also measured for the analysis of inflammation. The hormonal profile of progesterone and estrogen was also estimated.Results: The test compound presented a significant reduction in organ weight and restored the hepatic and renal enzymes. O-NPAT treatments enhanced the antioxidant enzyme level of catalase (CAT), superoxide dismutase (SOD), and total sulfhydryl (TSH), with a highly significant reduction in lactate dehydrogenase (LDH) and lipid peroxidation. Also, the decrease in fragmented DNA, hormonal levels (estradiol and progesterone), and inflammatory cytokines (IL-6 and TNF-α) justified the dosage efficacy further supported by histopathological findings.Conclusion: All results indicated the anti–breast tumor activity of O-NPAT and presented its possibility of exploitation for beneficial effects in breast cancer treatment.

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Immunomodulatory effects of a bioactive fraction of Strobilanthes crispus in NMU-induced rat mammary tumor model

Cited by 18 publications

References 38 publications

Reversal effect of Solanum dasyphyllum against rotenone-induced neurotoxicity

Reversal effect of Solanum dasyphyllum against rotenone-induced neurotoxicity

Anticancer Properties of Strobilanthes crispus: A Review

Triazine Derivative as Putative Candidate for the Reduction of Hormone-Positive Breast Tumor: In Silico, Pharmacological, and Toxicological Approach

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