Immunomodulatory effects and mechanisms of distraction osteogenesis

Yang, Shude; Wang, Ning; Ma, Yutong; Guo, Shuaichen; Guo, Shu; Sun, Hongchen

doi:10.1038/s41368-021-00156-y

Cited by 17 publications

(12 citation statements)

References 131 publications

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“…In the late stage of bone regeneration, the M2-polarized macrophages induce the secretion of TGF-β and IL-10, thereby inducing angiogenesis and osteogenesis [ [76] , [77] , [78] , [79] ]. Moreover, MSCs secrete IL-6, which triggers the sustained release of bone morphogenic protein-2 (BMP-2) and promotes the phosphorylation of suppressor of mothers against decapentaplegic (SMAD) via the TGF-β or MAPK signaling pathway in osteoblasts [ 80 ]. Therefore, the interplay between MSC immunomodulation and macrophage polarization regulates osteoblast maturation and bone mineralization.…”

Section: Macrophage Heterogeneity - Tissue Healing or Disease Progres...mentioning

confidence: 99%

Unraveling the potential of 3D bioprinted immunomodulatory materials for regulating macrophage polarization: State-of-the-art in bone and associated tissue regeneration

Dutta

Ganguly

Patil

et al. 2023

Bioactive Materials

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Section: Macrophage Heterogeneity - Tissue Healing or Disease Progres...mentioning

confidence: 99%

Unraveling the potential of 3D bioprinted immunomodulatory materials for regulating macrophage polarization: State-of-the-art in bone and associated tissue regeneration

Dutta

Ganguly

Patil

et al. 2023

Bioactive Materials

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“…Bone grafting has osteogenic potential, osteoinductive potential, and osteoconductive potential. Osteogenesis is the formation of bone by preosteoblasts and mesenchymal cells in the graft material (autologous bone) [ 101 , 102 , 103 ]. The bone-inductive capacity is defined as bone formation by bone morphogenetic proteins (BMPs) in autologous or allogeneic bone [ 104 , 105 , 106 ].…”

Section: Bone Graftingmentioning

confidence: 99%

Recent Clinical Treatment and Basic Research on the Alveolar Bone

Tsuchida

Nakayama

2023

Biomedicines

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The periodontal ligament is located between the bone (alveolar bone) and the cementum of the tooth, and it is connected by tough fibers called Sharpey’s fibers. To maintain healthy teeth, the foundation supporting the teeth must be healthy. Periodontal diseases, also known as tooth loss, cause the alveolar bone to dissolve. The alveolar bone, similar to the bones in other body parts, is repeatedly resorbed by osteoclasts and renewed by osteogenic cells. This means that an old bone is constantly being resorbed and replaced by a new bone. In periodontal diseases, the alveolar bone around the teeth is absorbed, and as the disease progresses, the alveolar bone shrinks gradually. In most cases, the resorbed alveolar bone does not return to its original form even after periodontal disease is cured. Gum covers the tooth surface so that it matches the shape of the resorbed alveolar bone, exposing more of the tooth surface than before, making the teeth look longer, leaving gaps between the teeth, and in some cases causing teeth to sting. Previously, the only treatment for periodontal diseases was to stop the disease from progressing further before the teeth fell out, and restoration to the original condition was almost impossible. However, a treatment method that can help in the regeneration of the supporting tissues of the teeth destroyed by periodontal diseases and the restoration of the teeth to their original healthy state as much as possible is introduced. Recently, with improvements in implant material properties, implant therapy has become an indispensable treatment method in dentistry and an important prosthetic option. Treatment methods and techniques, which are mainly based on experience, have gradually accumulated scientific evidence, and the number of indications for treatment has increased. The development of bone augmentation methods has contributed remarkably to the expansion of indications, and this has been made possible by various advances in materials science. The induced pluripotent stem cell (iPS) cell technology for regenerating periodontal tissues, including alveolar bone, is expected to be applied in the treatment of diseases, such as tooth loss and periodontitis. This review focuses on the alveolar bone and describes clinical practice, techniques, and the latest basic research.

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“…The diagnostic standards of bone union and bone non-union: bone union indicated the ones where the external fixator was removed successfully, whereas bone non-union represented the ones where bridging callus did not appear even after 9 months (an absence of bridging callus for at least three out of four cortices on plain radiographs) that needs autogenous bone transplantation (18)(19)(20). (3) The patients who had primary surgery. The exclusion criteria were: (1) The patients who could not complete the full course of bone lengthening therapy; (2) The patients who suffered from bone diseases that affected bone healing (e.g., osteomyelitis);…”

Section: Study Design and Patientsmentioning

confidence: 99%

The early posterior cortex pixel value ratio: a novel reliable indicator for distraction osteogenesis

Liu,

Wang

et al. 2023

Front. Surg.

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AimsWe aimed to explore the associations of the early PVR in four cortices with Healing Index (HI), Lengthening Index (LI), and External Fixator Index (EFI) in the bone union and non-union groups.MethodsA total of 52 patients, including 39 bone union and 13 bone non-union subjects, were recruited in this study. The general characteristics and PVR in four cortices in each group were explored. Afterward, the early PVR in four cortices, including medial, lateral, anterior, and posterior sides, were compared. Finally, the associations of the early PVR in four cortices with HI, LI, and EFI were also investigated.ResultsThe general characteristics of these patients were consistent, except for HI (31.54 ± 12.24 vs. 45.08 ± 27.10, P = 0.018) and EFI (57.63 ± 18.15 vs. 71.29 ± 24.60, P = 0.046). The growth of regenerated callus was asymmetrical in the bone union group (the posterior PVR seems to grow faster), whereas no statistical difference was obtained in the bone non-union group. Furthermore, the posterior PVR in the bone union group was significantly higher than that in the bone non-union group (the first month: 0.96 ± 0.17 vs. 0.86 ± 0.06, p = 0.047; the second month: 0.98 ± 0.14 vs. 0.89 ± 0.09, p = 0.041; the third month: 1.00 ± 0.12 vs. 0.92 ± 0.09, p = 0.039). Most importantly, the posterior PVR was inversely associated with HI, LI, and EFI (the first month: r = −0.343, p = 0.041; r = −0.346, p = 0.042; r = −0.352, p = 0.041; the second month: r = −0.459, p = 0.004; r = −0.277, p = 0.101; r = −0.511, p = 0.002; the third month: r = −0.479, p = 0.003; r = −0.398, p = 0.018; r = −0.551, p = 0.001) in the bone union group, respectively. However, this finding was lost in the bone non-union group.ConclusionThe early posterior cortex PVR seems to grow faster than the medial, lateral, and anterior sides in the bone union group, which represents an asymmetrical development pattern. Moreover, the posterior cortex PVR was negatively associated with HI, LI, and EFI, respectively. The posterior cortex PVR may be a novel and reliable detection index in the process of DO.

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Immunomodulatory effects and mechanisms of distraction osteogenesis

Cited by 17 publications

References 131 publications

Unraveling the potential of 3D bioprinted immunomodulatory materials for regulating macrophage polarization: State-of-the-art in bone and associated tissue regeneration

Unraveling the potential of 3D bioprinted immunomodulatory materials for regulating macrophage polarization: State-of-the-art in bone and associated tissue regeneration

Recent Clinical Treatment and Basic Research on the Alveolar Bone

The early posterior cortex pixel value ratio: a novel reliable indicator for distraction osteogenesis

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