Immunomodulatory Effect of Sertraline in a Rat Model of Rheumatoid Arthritis

Baharav, Ehud; Bar, Meytal; Taler, Michal; Gil-Ad, Irit; Karp, Leon; Weinberger, Abraham; Weizman, Abraham

doi:10.1159/000339109

Cited by 33 publications

(21 citation statements)

References 92 publications

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“…Conversely, other studies (Lanquillon et al 2000; Sluzewska et al 1996) and ours observed a significant decrease in cytokines in both responders and non-responders. Moreover, no clinical trial examined the effects of different sertraline doses on inflammatory cytokines and Baharav et al (2012), in an animal model of rheumatoid arthritis, observed that all employed doses of sertraline had a significant anti-inflammatory effect.…”

Section: Discussionmentioning

confidence: 99%

Cytokines plasma levels during antidepressant treatment with sertraline and transcranial direct current stimulation (tDCS): results from a factorial, randomized, controlled trial

et al. 2013

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Rationale The inflammatory hypothesis of depression states that increased levels of pro-inflammatory cytokines triggered by external and internal stressors are correlated to the acute depressive state. This hypothesis also suggests that pharmacotherapy partly acts in depression through anti-inflammatory effects. Transcranial direct current stimulation (tDCS) is a novel, promising, non-invasive somatic treatment for depression, although its antidepressant mechanisms are only partly understood. Objectives We explored the effects of tDCS and sertraline over the immune system during an antidepressant treatment trial. Methods In a 6-week, double-blind, placebo-controlled trial, 73 antidepressant-free patients with unipolar depression were randomized to active/sham tDCS and sertraline/placebo (2×2 design). Plasma levels of several cytokines (IL-2, IL-4, IL-6, IL-10, IL-17a, IFN-γ, and TNF-α) were determined to investigate the effects of the interventions and of clinical response on them. Results All cytokines, except TNF-α, decreased over time, these effects being similar across the different intervention-groups and in responders vs. non-responders. Conclusions tDCS and sertraline (separately and combined) acute antidepressant effects might not specifically involve normalization of the immune system. In addition, being one of the first placebo-controlled trials measuring cytokines over an antidepressant treatment course, our study showed that the decrease in cytokine levels during the acute depressive episode could involve a placebo effect, highlighting the need of further placebo-controlled trials and observational studies examining cytokine changes during depression treatment and also after remission of the acute depressive episode.

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Section: Discussionmentioning

confidence: 99%

Cytokines plasma levels during antidepressant treatment with sertraline and transcranial direct current stimulation (tDCS): results from a factorial, randomized, controlled trial

et al. 2013

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“…Conversely, in animal models of inflammation, antidepressant drugs appear to possess truly anti‐inflammatory properties. Anti‐inflammatory effects have been established for different classes of antidepressants, including selective serotonin reuptake inhibitors (SSRIs; such as sertraline and citalopram), tricyclic antidepressants (e.g., desipramine and imipramine), and atypical antidepressants (such as agomelatine, a melatonin receptor inhibitor) . The exact mechanisms of these effects remain unknown; the most widely held view is the elevation of intracellular cyclic AMP levels and resulting from this, the inhibition of astroglia and microglia .…”

Section: Role Of Inflammation In Epilepsy‐associated Depressionmentioning

confidence: 99%

Neurobehavioral comorbidities of epilepsy: Role of inflammation

2017

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Epilepsy is associated with a high incidence of comorbid neurologic and psychiatric disorders. This review focuses on the association of epilepsy with autism spectrum disorder (ASD) and depression. There is high concordance of these behavioral pathologies with epilepsy. We review data that unambiguously reveal that epilepsy, ASD, and depression are associated with elevated brain inflammatory markers and that these may interact with serotoninergic pathways. Interference with inflammatory pathways or actions can reduce the severity of seizures, depression, and ASD-like behavior. Inflammation in the brain can be induced by seizure activity as well as by behavioral, environmental, and physiologic stressors. Furthermore, induction of inflammation at an early time point during gestation and in early neonatal life can precipitate both an ASD-like phenotype as well as a more excitable brain. It appears likely that priming of the brain due to early inflammation could provide a means by which subsequent inflammatory processes associated with epilepsy, ASD, and depression may lead to comorbidity.

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“…Regarding sertraline, it is an antidepressant drug belonging to the group of SSRIs (selective serotonin reuptake inhibitors), which are known to exert anti-inflammatory actions [20]. Sertraline has also been demonstrated to represent effective treatment in an animal model of rheumatoid arthritis [21]. Based on this, a link between sertraline and psoriasis seems less likely.…”

Section: Discussionmentioning

confidence: 99%

Antipsychotic-associated psoriatic rash – a case report

et al. 2017

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BackgroundAntipsychotics are a heterogeneous group of drugs. Although, antipsychotics have been used for years, unexpected side effects may still occur. With this case report we focus on a possible association between psoriasis and antipsychotics.Data on the patient’s course of psychiatric disease, onset of psoriasis and its evolution were extracted from the patient’s medical files.Case presentationWe present a case of a 21-year-old female diagnosed with schizophrenia. She was initially treated with quetiapine, and later switched to aripiprazole due to weight gain. After initiation of antipsychotic treatment, the patient suffered from severe psoriasis lesions.ConclusionsAntipsychotics may possess immunological properties that may be involved in immune-mediated conditions, such as psoriatic rash. Further studies are warranted to determine causality and mechanism.

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Immunomodulatory Effect of Sertraline in a Rat Model of Rheumatoid Arthritis

Cited by 33 publications

References 92 publications

Cytokines plasma levels during antidepressant treatment with sertraline and transcranial direct current stimulation (tDCS): results from a factorial, randomized, controlled trial

Cytokines plasma levels during antidepressant treatment with sertraline and transcranial direct current stimulation (tDCS): results from a factorial, randomized, controlled trial

Neurobehavioral comorbidities of epilepsy: Role of inflammation

Antipsychotic-associated psoriatic rash – a case report

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