Immunomodulatory effect of pleuran (β-glucan from Pleurotus ostreatus) in children with recurrent respiratory tract infections

Jeseňák, Miloš; Majtán, Juraj; Rennerova, Zuzana; Kyselovič, Ján; Bánovčin, Peter; Hrubiško, M

doi:10.1016/j.intimp.2012.11.020

Cited by 106 publications

(79 citation statements)

References 24 publications

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“…55,56 Our observation of an increase in WBCs seems consistent with the mechanisms described for b-glucan and with the previous reporting of increased blood natural killer lymphocytes in children receiving fungal b-glucan. 22,57 To our knowledge, this is the first study reporting a potential impact of oral intake of yeast b-glucan on immune markers in healthy children. It is to be noted that the high prevalence of Blastocystis hominis in the current study (up to 27%) is consistent with reports of up to 33% prevalence of this parasite in China.…”

Section: Discussionmentioning

confidence: 89%

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Follow-up Formula Consumption in 3- to 4-Year-Olds and Respiratory Infections: An RCT

Jin

Liu

et al. 2014

Pediatrics

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OBJECTIVE: Children are vulnerable to diet inadequacies, which may affect immune function. Our objective was to determine if a follow-up formula (FUF) containing DHA, the prebiotics PDX and GOS, and yeast β-glucan affects incidence of respiratory infections and diarrheal disease in healthy children. METHODS: In a double-blind, randomized, controlled, prospective trial, 3-4 year old children were fed 3 servings per day of either a FUF with 25 mg DHA, 1.2 g PDX/GOS, and 8.7 mg yeast β-glucan per serving or an unfortified, cow’s milk-based beverage (control) for 28 weeks. Fecal and blood samples were collected to assess immune markers and iron/zinc status. Incidence of acute respiratory infections (ARI), diarrheal disease, and antibiotic treatment were obtained from medical records. RESULTS: The FUF group had fewer episodes and shorter duration of ARI (mean days [SE]; control = 4.3 [0.2]; FUF = 3.5 [0.2]; P = .007), less antibiotic use (n [%]; control = 21 [14%]; FUF = 8 [5%]; P = .01), and fewer missed days of day care due to illness. No diarrheal disease was diagnosed in either group. The FUF group had higher interleukin-10 and white blood cell count at the end of the study. There were no differences in hemoglobin, serum ferritin and zinc, or fecal secretory immunoglobulin A. CONCLUSIONS: Daily consumption of a FUF was associated with fewer episodes and shorter duration of ARI, as well as less antibiotic use. The children who consumed the FUF had increased interleukin-10 and white blood cells, suggesting an antiinflammatory mechanism and/or an increase of effector immune cells.

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Section: Discussionmentioning

confidence: 89%

“…[19][20][21] A b-glucan from a different fungal source was reported to promote an increase of blood NK lymphocytes and fewer ARIs in children with recurrent ARIs. 22 However, no data on immune benefits of dietary intake of yeast b-glucan in children is currently available.…”

mentioning

confidence: 99%

Follow-up Formula Consumption in 3- to 4-Year-Olds and Respiratory Infections: An RCT

Jin

Liu

et al. 2014

Pediatrics

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“…In addition, glucan manifested significant effects in prevention or modulation of infectious diseases (Renzetti et al, 2009;Ramberg et al, 2010;Novak and Vetvicka, 2008). Some recent observations showed that glucan has palative anti-allergic effects (Ku et al, 2012), even in children with respiratory problems (Jesenak et al, 2013b). The possibility that these effects might be manifested via decreasing proinflammatory cytokines such as IL-6 and TNF-α and increasing of secretion of IL-10 and accession of cellular antioxidants was suggested (Senoglu et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Placebo-Driven Clinical Trials of Transfer Point Glucan #300 in Children With Chronic Respiratory Problems: Iii. Clinical Findings

Větvička

Richter²,

Svozil³

et al. 2013

American Journal of Immunology

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The role of glucan in stimulation of immune reactions has been studied for decades. In this report we focused on the effects of orally administered glucan in children with chronic respiratory problems. We measured the physical endurance using a 6MWT test and the levels of eNO in 50 children aged 8-12 years and evaluated the effects of 100 mg/d oral dose of glucan. We found significant improvements in physical indurance and exhaled nitric oxide in glucan-treated children. In addition, strong improvements in general conditions were found. Short-term oral application of natural immunomodulator β-glucan enhancers the overall health and regulation of energetic metabolism in children with chronic respiratory problems.

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“…® also significantly decreased the frequency of flu and flu-like diseases and the number of lower respiratory tract infections [12]. In the similar study with 50 athletes Imunoglukan P4H…”

Section: Imunoglukan P4hmentioning

confidence: 61%

Beta-(1,3/1,6)-D-glucan Helps to Decrease Opportunistic Infections in Crohn's Disease Patients Treated with Biological Therapy

Bátovský¹,

Zamborsky²,

Khaled³

et al. 2015

Arch Clin Gastroenterol

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Immunomodulatory effect of pleuran (β-glucan from Pleurotus ostreatus) in children with recurrent respiratory tract infections

Cited by 106 publications

References 24 publications

Follow-up Formula Consumption in 3- to 4-Year-Olds and Respiratory Infections: An RCT

Follow-up Formula Consumption in 3- to 4-Year-Olds and Respiratory Infections: An RCT

Placebo-Driven Clinical Trials of Transfer Point Glucan #300 in Children With Chronic Respiratory Problems: Iii. Clinical Findings

Beta-(1,3/1,6)-D-glucan Helps to Decrease Opportunistic Infections in Crohn's Disease Patients Treated with Biological Therapy

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