Immunomodulatory effect of Echinometra Mathaeis҆ coelomic fluid extract combined with gonad and coelomic extract solely on protoscolices of hydatid cysts in-vitro

Navvabi, Azita; Homaei, Ahmad; Khademvatan, Shahram; Ansari, Mohammad Hassan Khadem; Keshavarz, Mousa

doi:10.1016/j.bcab.2021.102055

Cited by 1 publication

(2 citation statements)

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“…Bioactive peptides derived from sea cucumbers have a broad range of clinical applications, including antihepatitis, antioxidant, anticoagulant, anticancer, and antimicrobial uses. Sea cucumber‐derived saponins appear to be helpful in the therapy of diabetes and have therefore attracted much attention 10,19–21 …”

Section: Introductionmentioning

confidence: 99%

“…Sea cucumber-derived saponins appear to be helpful in the therapy of diabetes and have therefore attracted much attention. 10,[19][20][21] Holothuria parva is a worm-like echinoderm with soft, gelatinous bodies and oily skin, belonging to the Holothuridea family found on the southern coast of Iran in the tidal zone. 22,23 In Iran, H. parva shows the greatest diversity in the shallow waters of the tropics.…”

Section: Introductionmentioning

confidence: 99%

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Exploring in vitro effect of silver nanoparticles and Holothuria parva extracts on kinetics and stability of α‐amylase

Edrispour

Homaei

2022

Biotech and App Biochem

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Diabetes is a chronic metabolic disorder characterized by elevated blood glucose levels. Major limitations of synthetic drugs, including high cost, efficacy, and adverse side effects, have prompted researchers to seek more effective and low‐cost alternative therapies with fewer adverse effects. Marine life forms are considered the most important sources of biologically active natural products due to their secondary metabolites. In this research, sea cucumber Holothuria parva was collected from coastal areas of Bandar Lengeh, Hormozgan, Iran, and was then subjected to extraction. The results showed that compounds extracted from Holothuria parva had a stimulatory effect on enzyme activity, and in the presence of these compounds, the Vmax value of the enzyme was increased about two times, while the Km value was reduced. The phosphate buffer form of extracts had the greatest impact on enzyme activity. Upon an increase in the concentration of silver nanoparticles (AgNPs), the α‐amylase activity was inhibited in parallel. Silver nanoparticles exhibited the highest enzyme inhibition with an IC50 of 0.86 mg/ml. Silver nanoparticles showed anti‐α‐amylase activity and had the ability to decrease intestinal glucose uptake in diabetic individuals when prescribed as a novel supplementary medicine.

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Section: Introductionmentioning

confidence: 99%