Immunomodulatory effect of Bifidobacterium�breve on experimental allergic rhinitis in BALB/c mice

Ren, Jianjun; Zhao, Yu; Huang, Shi; Lv, Dan; Yang, Fan; Lou, Lin; Zheng, Yongbo; Zhang, Jie; Liu, Shixi; Zhang, Nan; Bachert, Claus

doi:10.3892/etm.2018.6704

Cited by 17 publications

(19 citation statements)

References 41 publications

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“…Oral probiotics can alter the respiratory microbiota and have been advocated as a novel therapeutic strategy for AAD ( 27 ). Our findings are consistent with other reports demonstrating improvement in allergic rhinitis and asthma inflammation through oral administration of Bifidobacterium breve ( 28 ) and Lactobacillus plantarum ( 29 ). However, levels of the main cytokine secreted by Tregs to mediate immune suppression, IL-10, were significantly higher in ATCC 29148 intervention group as compared with the levels in control group.…”

Section: Discussionsupporting

confidence: 93%

Bacteroides thetaiotaomicron Ameliorates Experimental Allergic Airway Inflammation via Activation of ICOS+Tregs and Inhibition of Th2 Response

Pang

Jiang

et al. 2021

Front. Immunol.

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Inhibition of allergic airway diseases (AAD) by immunomodulation of the adaptive immune system through restoration of the enteric dysbiosis is an emerging therapeutic strategy. Patients with allergic rhinitis (n = 6) and healthy controls (n = 6) were enrolled, and gut microbiome composition analysis was performed by 16S rDNA sequencing. We also established an ovalbumin (OVA)-induced allergic airway inflammation murine model. Dysbiosis of the gut flora was observed in both AAD patients and the mice, with the decrease of the biodiversity and the quantity of the Bacteroidetes phylum. Oral application of Bacteroides (B.) thetaiotaomicron ameliorated the symptoms of OVA-induced airway hyperresponsiveness (AHR) and attenuated the airway inflammation in mice. In addition, nasal lavage fluid (NALF) and bronchoalveolar lavage fluid (BALF) from AAD mice orally administered with B. thetaiotaomicron showed reduced numbers of immune cells, and diminished secretion of T helper (Th)-2 cytokines (IL-4, IL-5, and IL-13) compared with the corresponding control mice, whereas the levels of Th1 cytokineIFN-γ was not changed in both the groups. When B. thetaiotaomicron was co-administered with metronidazole in AAD mice, the immunomodulatory effect was weakened and the allergic inflammatory response was aggravated. The ratios of CD4+Foxp3+ cells, CD4+ICOS+ T cells, CD4+ICOS+ Foxp3+ regulatory T cells, and IL-10-expressing CD4+Foxp3+ cells were increased in lymphocytes of spleen, mesenteric, and cervical lymph nodes of AAD mice administrated with B. thetaiotaomicron. Therefore, our data indicate that oral administration of B. thetaiotaomicron effectively inhibited the development of AAD in murine model; inhibition was mediated by the activation of Tregs and inhibition of Th2 response without promoting a Th1 response.

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Section: Discussionsupporting

confidence: 93%

Bacteroides thetaiotaomicron Ameliorates Experimental Allergic Airway Inflammation via Activation of ICOS+Tregs and Inhibition of Th2 Response

Pang

Jiang

et al. 2021

Front. Immunol.

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“…Kwon et al reported that oral administration of L. sakei WIKIM30 induces tolerogenic DCs and Treg cells, thereby improving allergic symptoms in mouse models of allergic dermatitis (48). It also has been reported that oral administration of Bifidobacterium increases Treg numbers and improves allergic symptoms in OVA-sensitized allergy model mice (49,50).…”

Section: Discussionmentioning

confidence: 99%

Oral Administration of Flavonifractor plautii Strongly Suppresses Th2 Immune Responses in Mice

et al. 2020

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The bacterium Flavonifractor plautii (FP), which is found in human feces, has been reported to participate in catechin metabolism in the gut, but this bacterium's effects on immune function are unclear. We assessed the effect of oral administration of FP on the immune response in ovalbumin (OVA) -sensitized mice. We demonstrated that the FP treatment suppressed interleukin (IL)-4 in splenocytes and OVA-specific IgE production in serum from OVA-sensitized mice. Moreover, oral administration of FP augmented CD4 + CD25 + T cells and CD103 + CD11c + DCs. In animals of the FP group, the proportion of FP was increased in the mesenteric lymph nodes (MLNs), as was the proportion of Deferribacteres in the cecum. Oral administration of FP may inhibit the Th2 immune response by incorporation into the MLNs and/or by inducing changes in the gut microbiota. Thus, FP may be useful in alleviating antigen-induced Th2 immune responses.

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“…Our study also found elevated levels of Bifidobacterium in the nares microbiome during spaceflight. Oral administration of some Bifidobacterium species has been shown to ameliorate allergic rhinitis symptoms in human patients 70 and in a mouse model of allergic rhinitis 71 . Whether the observed increase of Bifidobacterium abundance in the nares may have a similar protective effect on astronauts during spaceflight warrants further investigations.…”

Section: Discussionmentioning

confidence: 99%

Study of the impact of long-duration space missions at the International Space Station on the astronaut microbiome

Voorhies

Ott

Mehta

et al. 2019

Sci Rep

183

197

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Over the course of a mission to the International Space Station (ISS) crew members are exposed to a number of stressors that can potentially alter the composition of their microbiomes and may have a negative impact on astronauts’ health. Here we investigated the impact of long-term space exploration on the microbiome of nine astronauts that spent six to twelve months in the ISS. We present evidence showing that the microbial communities of the gastrointestinal tract, skin, nose and tongue change during the space mission. The composition of the intestinal microbiota became more similar across astronauts in space, mostly due to a drop in the abundance of a few bacterial taxa, some of which were also correlated with changes in the cytokine profile of crewmembers. Alterations in the skin microbiome that might contribute to the high frequency of skin rashes/hypersensitivity episodes experienced by astronauts in space were also observed. The results from this study demonstrate that the composition of the astronauts’ microbiome is altered during space travel. The impact of those changes on crew health warrants further investigation before humans embark on long-duration voyages into outer space.

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Immunomodulatory effect of Bifidobacterium�breve on experimental allergic rhinitis in BALB/c mice

Cited by 17 publications

References 41 publications

Bacteroides thetaiotaomicron Ameliorates Experimental Allergic Airway Inflammation via Activation of ICOS+Tregs and Inhibition of Th2 Response

Bacteroides thetaiotaomicron Ameliorates Experimental Allergic Airway Inflammation via Activation of ICOS+Tregs and Inhibition of Th2 Response

Oral Administration of Flavonifractor plautii Strongly Suppresses Th2 Immune Responses in Mice

Study of the impact of long-duration space missions at the International Space Station on the astronaut microbiome

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