Immunomodulatory effect of 1, 25 dihydroxy vitamin D3 on the expression of RNA sensing pattern recognition receptor genes and cytokine response in dengue virus infected U937-DC-SIGN cells and THP-1 macrophages

Jadhav, Nandadeep J.; Gokhale, Sarangi; Seervi, M.; Patil, Poonam; Alagarasu, Kalichamy

doi:10.1016/j.intimp.2018.07.019

Cited by 29 publications

(27 citation statements)

References 27 publications

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“…Vitamin D is thought to modulate the immune responses by selective suppression of effector functions such as inflammatory cytokine production and leukocyte infiltration into inflammatory sites, which may minimise inflammation. [77][78][79] Vitamin D deficiency was also shown to be associated with an increased CD4/CD8 ratio. 80 If this is the case, poor vitamin D status may reduce the ability of the immune system to produce activated T lymphocytes such as CD8+ T cells that can attack virally infected B cells, and impair the control of viral infections such as EBV.…”

Section: Immunoregulatory Functionmentioning

confidence: 99%

“…Besides its classical role in bone and calcium homeostasis, vitamin D is a potent immune regulator in different settings as described in Figure , box 2. Vitamin D is thought to modulate the immune responses by selective suppression of effector functions such as inflammatory cytokine production and leukocyte infiltration into inflammatory sites, which may minimise inflammation . Vitamin D deficiency was also shown to be associated with an increased CD4/CD8 ratio .…”

Section: Introductionmentioning

confidence: 99%

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The interplay between vitamin D and viral infections

Teymoori‐Rad

Shokri

Salimi

et al. 2019

Reviews in Medical Virology

234

230

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Summary The pleiotropic role of vitamin D has been explored over the past decades and there is compelling evidence for an epidemiological association between poor vitamin D status and a variety of diseases. While the potential anti‐viral effect of vitamin D has recently been described, the underlying mechanisms by which vitamin D deficiency could contribute to viral disease development remain poorly understood. The possible interactions between viral infections and vitamin D appear to be more complex than previously thought. Recent findings indicate a complex interplay between viral infections and vitamin D, including the induction of anti‐viral state, functional immunoregulatory features, interaction with cellular and viral factors, induction of autophagy and apoptosis, and genetic and epigenetic alterations. While crosstalk between vitamin D and intracellular signalling pathways may provide an essential modulatory effect on viral gene transcription, the immunomodulatory effect of vitamin D on viral infections appears to be transient. The interplay between viral infections and vitamin D remains an intriguing concept, and the global imprint that vitamin D can have on the immune signature in the context of viral infections is an area of growing interest.

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Section: Immunoregulatory Functionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The interplay between vitamin D and viral infections

Teymoori‐Rad

Shokri

Salimi

et al. 2019

Reviews in Medical Virology

234

230

View full text Add to dashboard Cite

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“…It has been reported during influenza A infection that IFN-beta, tumor necrosis factor (TNF)-alfa, IL-8 and IL-6 in the lungs were reduced in response to treatment with vitamin D [ 99 ]; during RSV infection the NfkB inhibitor was induced [ 100 ]; similar immunomodulatory effects were also described during Dengue infection [ 101 ]. Vitamin D can suppress excessive activity of IFN gamma-activated macrophages [ 102 ]; decrease macrophagic cytokines release through upregulation of MKP-1 [ 103 ]; reduce the production of metalloproteinase MMP-9 in keratinocytes, whose excessive and potentially harmful activity is induced by TNF alfa during hyperinflammation [ 104 ].…”

Section: Vitamin Dmentioning

confidence: 99%

The Role of Micronutrients in Support of the Immune Response against Viral Infections

et al. 2020

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Viral infections are a leading cause of morbidity and mortality worldwide, and the importance of public health practices including handwashing and vaccinations in reducing their spread is well established. Furthermore, it is well known that proper nutrition can help support optimal immune function, reducing the impact of infections. Several vitamins and trace elements play an important role in supporting the cells of the immune system, thus increasing the resistance to infections. Other nutrients, such as omega-3 fatty acids, help sustain optimal function of the immune system. The main aim of this manuscript is to discuss of the potential role of micronutrients supplementation in supporting immunity, particularly against respiratory virus infections. Literature analysis showed that in vitro and observational studies, and clinical trials, highlight the important role of vitamins A, C, and D, omega-3 fatty acids, and zinc in modulating the immune response. Supplementation with vitamins, omega 3 fatty acids and zinc appears to be a safe and low-cost way to support optimal function of the immune system, with the potential to reduce the risk and consequences of infection, including viral respiratory infections. Supplementation should be in addition to a healthy diet and fall within recommended upper safety limits set by scientific expert bodies. Therefore, implementing an optimal nutrition, with micronutrients and omega-3 fatty acids supplementation, might be a cost-effective, underestimated strategy to help reduce the burden of infectious diseases worldwide, including coronavirus disease 2019 (COVID-19).

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“…Dengue virus (DENV) is responsible for the development of dengue fever, a mosquito-borne tropical disease. A high dose of 1,25(OH)2D 3 had an immunoregulatory role in reducing inflammation during DENV infections in U937-DC-SIGN and THP1 macrophages infected with DENV-2 [167]. Mechanistically, the suppression of inflammatory cytokine response by VD treatment during DENV infection was mediated via the toll-like receptor (TLR) 4/NF-κB/miR-155-5p/suppressor of cytokine signaling (SOCS)-1 axis [179].…”

Section: Dengue Virusmentioning

confidence: 99%

Controversial Effects of Vitamin D and Related Genes on Viral Infections, Pathogenesis, and Treatment Outcomes

Lee

2020

Nutrients

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Vitamin D (VD) plays an essential role in mineral homeostasis and bone remodeling. A number of different VD-related genes (VDRG) are required for the metabolic activation of VD and the subsequent induction of its target genes. They include a set of genes that encode for VD-binding protein, metabolic enzymes, and the VD receptor. In addition to its well-characterized skeletal function, the immunoregulatory activities of VD and the related polymorphisms of VDRG have been reported and linked to its therapeutic and preventive actions for the control of several viral diseases. However, in regards to their roles in the progression of viral diseases, inconsistent and, in some cases, contradictory results also exist. To resolve this discrepancy, I conducted an extensive literature search by using relevant keywords on the PubMed website. Based on the volume of hit papers related to a certain viral infection, I summarized and compared the effects of VD and VDRG polymorphism on the infection, pathogenesis, and treatment outcomes of clinically important viral diseases. They include viral hepatitis, respiratory viral infections, acquired immunodeficiency syndrome (AIDS), and other viral diseases, which are caused by herpesviruses, dengue virus, rotavirus, and human papillomavirus. This review will provide the most current information on the nutritional and clinical utilization of VD and VDRG in the management of the key viral diseases. This information should be valuable not only to nutritionists but also to clinicians who wish to provide evidence-based recommendations on the use of VD to virally infected patients.

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Immunomodulatory effect of 1, 25 dihydroxy vitamin D3 on the expression of RNA sensing pattern recognition receptor genes and cytokine response in dengue virus infected U937-DC-SIGN cells and THP-1 macrophages

Cited by 29 publications

References 27 publications

The interplay between vitamin D and viral infections

The interplay between vitamin D and viral infections

The Role of Micronutrients in Support of the Immune Response against Viral Infections

Controversial Effects of Vitamin D and Related Genes on Viral Infections, Pathogenesis, and Treatment Outcomes

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