Immunomodulatory and Mechanistic Considerations of Hibiscus sabdariffa (HS) in Dysfunctional Immune Responses: A Systematic Review

Umeoguaju, Francis U.; Ephraim-Emmanuel, Benson Chukwunweike; Uba, Joy O.; Bekibele, G. E.; Chigozie, Nwondah; Orisakwe, Orish Ebere

doi:10.3389/fimmu.2021.550670

Cited by 10 publications

(4 citation statements)

References 83 publications

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“…An important mechanism involved in the anti-inflammatory activities of hibiscus extracts is its ability to suppress the generation of oxidative stress and cellular damage in cells. The conjugated forms of quercetin and kaempferol often detected in the plasma after intake of hibiscus could indicate long-lasting cellular antioxidant effects because of their long plasma half-life [ 30 ]. Recently, hibiscus acid was reported as a nutraceutical approach for the treatment of chronic myelogenous leukemia due to protein response observed by activation of eIF2α/ATF4 pathway that induced cell cycle arrest at G2/M phase and DNA fragmentation in leukemia K562 cells [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

In Vitro Gastrointestinal Digestion Affects the Bioaccessibility of Bioactive Compounds in Hibiscus sabdariffa Beverages

et al. 2023

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Hibiscus sabdariffa possess great versatility to be used as an ingredient for a whole range of products with natural-based ingredients, which are growing in popularity due to the health benefits of bioactive compounds (BC). Therefore, the objective of this study was to characterize the BC content in Hibiscus beverages and to evaluate their in vitro bioaccessibility. Results showed significant differences (p < 0.05) in the total contents of BC prior to the in vitro intestinal digestion. Hibiscus acid was the most abundant compound identified. Thirty-five compounds were identified in the Hibiscus beverage at the initial stage, while a maximum of 15 compounds were quantified in the different fractions of gastrointestinal digestion. After digestion, significant differences were found compared with the initial content of BC. That phenolic acids were the less bioaccessible group, while flavonoids were the most diverse. Principal components analysis showed different clusters and changes in the profiles of BC present at the initial stage and those bioaccessible, showing that intestinal digestion significantly affects the BC profile of the beverage.

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Section: Discussionmentioning

confidence: 99%

In Vitro Gastrointestinal Digestion Affects the Bioaccessibility of Bioactive Compounds in Hibiscus sabdariffa Beverages

et al. 2023

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“…The role of chemokines and adhesion molecules in modulating the immune response, leading to a substantial disturbance of mediators' expression, leads to the enhancement or inhibition of the immune response (Sokol and Luster, 2015). The H. sabdariffa flower mediates its inhibitory effect on the inflammatory immune response through modulation of the expression of chemokines and adhesion molecules, as well as inhibition of humoral antibody formation and phagocytic ability (Umeoguaju et al, 2021).…”

Section: Anthocyanin-foxp3mentioning

confidence: 99%

Anthocyanin, tartaric acid, ascorbic acid of roselle flower (Hibiscus sabdariffa L.) for immunomodulatory adjuvant therapy in oral manifestation coronavirus disease-19: An immunoinformatic approach

Ramadhani¹,

Nugraha²,

Rahmadhani³

et al. 2022

J Pharm Pharmacogn Res

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Context: Oral manifestations that arose from COVID-19 infection often causes morbidity and systemic drug administration is less effective. Roselle flower (Hibiscus sabdariffa) is one of the plants that is often used in infusion as it gives health benefits. Hence, H. sabdariffa may benefit from adjuvant therapy to treat oral manifestation due to COVID-19. Aims: To investigate the potential of H. sabdariffa anthocyanins, tartaric acid, and ascorbic acid chemical compounds as antiviral, anti-inflammatory, antioxidant, and increasing tissue regeneration in oral manifestation due to COVID-19 infection in silico. Methods: Chemical compounds consisted of anthocyanins, (+)-tartaric acid, and ascorbic acid beside target proteins consisted of ACE2-spike, Foxp3, IL-10, IL6, IL1β, VEGF, FGF-2, HSP70, TNFR and MDA-ovalbumin were obtained from the database, ligand samples were selected through absorption, distribution, metabolism, excretion and toxicology analysis, then molecular docking simulations, identification of protein-ligand interactions, and 3D visualization were performed. Results: Anthocyanins, tartaric acid, and ascorbic acid are the active compounds in H. sabdariffa, which act as antioxidants. The activity of anthocyanin compounds is higher than other compounds through value binding affinity, which is more negative and binds to specific domains of target proteins by forming weak binding interactions that play a role in biological responses. Anthocyanins have the most negative binding energy compared to tartaric-acid and ascorbic acid. Conclusions: Anthocyanins act as antioxidants; this mechanism increases heat shock protein-70 (HSP70), which may play an important role in increasing wound regeneration of oral manifestation in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as documented in silico.

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“…Different regions of the world have different names for it. In a few tropical nations, red calyxes are frequently consumed as food and drink [7].…”

Section: Introductionmentioning

confidence: 99%

Biofabricated Green Synthesized Hibiscus Silver Nanoparticles Potentiate Antibacterial Activity and Cytotoxicity in Human Lung Cancer Cells

Ahirwar,

Jain

et al. 2024

Appl Biochem Biotechnol

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Traditional medicine has long employed the shrub Hibiscus sabdariffa to treat a variety of illnesses. The biochemical characteristics of nanoparticles of silver made using the plant extract and plant extracts of Hibiscus sabdariffa were examined in this work.According to the results, the plant extract of Hibiscus sabdariffa had a total phenolic quantity of 84.9 mg/gm and a total quantity of avonoids of 41.50 mg/gm. The extract also showed antibacterial action against Escherichia coli and Staphylococcus aureus (75.15% scavenging activity). The nanoparticles of silver from plant extracts were stable in PBS solution for at least 30 days and had a mean size of particles of 21.22 nm. Human cancer of the lung line of cells A-549 was effectively cytotoxic and antiin ammatory by the silver nanoparticles.Overall, the research's ndings demonstrate the fascinating biological activity of the nanoparticles of silver made from the extract of the Hibiscus sabdariffa plant. To assess these compounds' potential as medicines, more research is required.

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Immunomodulatory and Mechanistic Considerations of Hibiscus sabdariffa (HS) in Dysfunctional Immune Responses: A Systematic Review

Cited by 10 publications

References 83 publications

In Vitro Gastrointestinal Digestion Affects the Bioaccessibility of Bioactive Compounds in Hibiscus sabdariffa Beverages

In Vitro Gastrointestinal Digestion Affects the Bioaccessibility of Bioactive Compounds in Hibiscus sabdariffa Beverages

Anthocyanin, tartaric acid, ascorbic acid of roselle flower (Hibiscus sabdariffa L.) for immunomodulatory adjuvant therapy in oral manifestation coronavirus disease-19: An immunoinformatic approach

Biofabricated Green Synthesized Hibiscus Silver Nanoparticles Potentiate Antibacterial Activity and Cytotoxicity in Human Lung Cancer Cells

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